A5102715854- Cervical Cancer and HPV Research
- Genital Health and Disease
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Endometrial and Cervical Cancer Treatments
- Urological Disorders and Treatments
- Head and Neck Surgical Oncology
- Infectious Diseases and Mycology
- Viral-associated cancers and disorders
- Oral Health Pathology and Treatment
- Sinusitis and nasal conditions
- Global Cancer Incidence and Screening
- Cancer and Skin Lesions
- Oral and Maxillofacial Pathology
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Lung Cancer Research Studies
- Reproductive tract infections research
- Cleft Lip and Palate Research
- Colorectal Cancer Screening and Detection
- Ethics and Legal Issues in Pediatric Healthcare
Institut d'Investigació Biomédica de Bellvitge
2011-2024
Centro de Investigación Biomédica en Red de Cáncer
2018-2024
Institut Català d'Oncologia
2014-2024
Instituto de Salud Carlos III
2020-2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2016-2024
Centro de Investigación Biomédica en Red
2020-2024
Hospital Quirónsalud Barcelona
2016-2020
Bellvitge University Hospital
2018
Institut Català d'Ornitologia
2010-2017
Centro de Investigación del Cáncer
2016
We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable human papillomavirus (HPV-AFs) using six HPV-related biomarkers viral detection, transcription, cellular transformation. Formalin-fixed, paraffin-embedded cancer tissues the oral cavity (OC), pharynx, larynx were collected from pathology archives in 29 countries. All samples subject histopathological evaluation, DNA quality control, HPV-DNA detection. Samples containing further HPV...
Knowledge about human papillomaviruses (HPV) types involved in anal cancers some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution a series of invasive intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN cases 496 diagnosed 1986 to 2011. After histopathological evaluation formalin-fixed paraffin-embedded samples, detection genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset 116 further tested for...
The goal of our study was to provide comprehensive data on the worldwide human papillomavirus (HPV) genotype distribution in patients with invasive cervical adenocarcinoma correlation histologic tumor subtypes, geographical location, patients' age, and duration sample storage. Paraffin-embedded samples 760 cases were collected worldwide. A three-level pathology review performed obtain consensus diagnoses 682 determined be eligible for further analysis. HPV DNA detection genotyping using...
Many countries, mainly high- and upper-middle income, have implemented human papillomavirus (HPV) vaccination programs, with 47 million women receiving the full course of vaccine (three doses) in 2014. To evaluate potential impact HPV vaccines reduction HPV-related disease, we aimed to estimate type distribution burden anogenital head neck cancers attributable types (HPVs 16/18/31/33/45/52/58/6/11) included currently licensed vaccines.
One third to one half of penile squamous cell carcinomas (SCCs) are related human papillomavirus (HPV) infection. Viral detection is usually carried out by polymerase chain reaction (PCR) or other molecular methods. In this study, we evaluated p16(INK)⁴(a) immunohistochemical expression, which simpler and less costly, as a potential marker high-risk HPV (HR-HPV) infection in SCC.We pathologically classified 202 invasive performed genotyping short PCR fragment (SPF)₁₀ immunohistochemistry. We...
Human papillomavirus (HPV) has been reported in 12-82% of penile squamous cell carcinomas (SCC). There is an association the virus with basaloid and warty but prevalence variable. The causes these variations are not clear. They may be owing to geographic differences, use different techniques detect HPV, status original paraffin blocks, or variable criteria tumor classification. aims study were determine HPV SCC subtypes using a sensitive technique, investigate genotypes involved, search for...
From the pathogenic point of view, penile cancers may be grouped in human papillomavirus-related and unrelated tumors, each one them with distinctive morphologic features. The former are predominantly composed small, undifferentiated basaloid cells, more or less prominent koilocytic changes, latter keratinizing differentiated squamous cells. same cellular types observed precancerous lesions. On basis these observations, we constructed a novel nomenclature for lesions classified as...
There are at least two different etio‐pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent HPV. We aimed to describe histological characteristics HPV‐associated ‐independent tumors determine best strategy identify HPV in VSCC. A single paraffin block was available review from a series 1,594 VSCCs. In all cases DNA detection analyzed using SPF10PCR/DEIA/LiPA25 system p16...
Abstract There is limited understanding of epidemiology and time trends human papilloma virus (HPV)‐driven head neck cancers (HNC) in Japan, especially outside the oropharynx. To assess HPV‐driven HNC, a non‐interventional study (BROADEN) HNC patients diagnosed 2008–2009 2018–2019 was conducted Japan. Adult with oropharyngeal, nasopharyngeal, laryngeal, hypopharyngeal or oral cavity were included this study. HPV centrally tested using p16INK4a immunohistochemistry, HPV‐DNA PCR E6*I mRNA....
Contribution over time of human papillomavirus (HPV) types in cancers has been poorly documented. Such data is fundamental to measure current HPV vaccines impact the years come. We estimated type-specific distribution a large international series invasive cervical cancer (ICC) 70 prior vaccination. Paraffin embedded ICC cases diagnosed between 1940 and 2007 were retrieved from eleven countries Central-South America, Asia Europe. Included reported have low-medium screening uptake. Information...
Neuroendocrine tumors (NET) of the cervix are rare with a very aggressive course. The human papillomavirus (HPV) has been linked to its etiology. objective this study is describe HPV prevalence and genotype distribution NET.Forty-nine histological neuroendocrine features were identified among 10,575 invasive cervical cancer (ICC) cases from an international study. DNA detection was done using SPF10/DEIA /LiPA25 system. Immunohistochemical (IHC) staining for markers (chromogranin A,...
The careHPV assay is a test for high-risk (HR) human papillomaviruses (HPV) detection designed to be affordable in resource-poor settings. We evaluated the performance of screening among 1052 women living with HIV/AIDS included HARP (HPV Africa Research Partnership) study Burkina Faso (BF) and South (SA). Cervical samples were tested HR-HPV by INNO-LiPA HPV genotyping Extra assays. All had Pap smear testing, visual inspection acetic acid/Lugol's iodine (VIA/VILI) colposcopy. biopsies...
Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs) originate from high-grade intraepithelial lesions, also named usual type neoplasia. However, growing evidence suggests that morphologic studies have limitations in predicting HPV status lesions. We aimed to evaluate adjacent lesions a series of DNA HPV-positive VSCCs, focusing on unusual histologic patterns mimicking differentiated neoplasia (dVIN) or lichen sclerosus (LS). identified 326 VSCC with at least 1...
Literature on the role of human papillomavirus (HPV) in head and neck cancer (HNC) Italy is limited, especially for non-oropharyngeal tumours. Within context HPV-AHEAD study, we aimed to assess prognostic value different tests or test algorithms judging HPV carcinogenicity HNC factors related positivity at European Institute Oncology. We conducted a retrospective cohort study (2000–2010) total 696 primary patients. Formalin-fixed, paraffin-embedded tissues were studied. All HPV-DNA-positive...
Abstract Objectives To describe human papillomavirus (HPV) distribution in invasive cervical carcinoma (ICC) from Mali and Senegal to compare type‐specific relative contribution among sub‐Saharan African (SSA) countries. Methods A multicentric study was conducted collect paraffin‐embedded blocks of ICC. Polymerase chain reaction, DNA enzyme immunoassay line probe assay were performed for HPV detection genotyping. Data SSA (Mozambique, Nigeria Uganda) 35 other countries compared. Results One...
Human papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which shown strong correlation with mutation status. However, few studies applied this new six-pattern framework none of them exhaustively compared IHC positivity between invasive VSCC adjacent skin lesion. We performed in a series 779 HPV-independent evaluated the slides following newly...
There are 3 distinct variants of penile squamous cell carcinoma frequently associated with human papillomavirus (HPV): basaloid, warty-basaloid, and warty carcinomas. Considering the high incidence rates cancer in some countries, a large international study was designed to evaluate presence HPV, its genotype distribution, association histologic types cancer. In this review >900 cases, we found group highly papillary neoplasms composed basophilic cells resembling urothelial tumors but HPV....
The objective of this study was to describe prior negative screening history and symptoms around the time diagnosis incident cervical cancer (CC) cases diagnosed between 2000 2010 within Asturias public health system.Records from 374 women with CC all hospitals in were retrieved. Clinical information, FIGO stage previous cytological data extracted clinical histopathological records. Proportional differences assessed using chi-square tests. Logistic regression analysis used estimate odds...
Background Human papillomavirus (HPV) is the cause of a fraction head and neck squamous cell carcinoma. Although this relation well-known, it still not clear role HPV in premalignant oral lesions such as lichen planus (OLP) dysplasia. We aimed to evaluate HPV-DNA prevalence type distribution set biopsies obtained from patients diagnosed with OLP dysplasia, well these lesions. Methods A retrospective cohort all consecutively March 30th 1995 May 21st 2014 at Hospital Bellvitge Odontological...
Two etiopathogenic types of vulvar squamous cell carcinoma (VSCC) have been described: human papillomavirus (HPV)-associated and HPV-independent. Precursor lesions, frequently identified in the adjacent skin, are also distinct 2 VSCC: high-grade intraepithelial lesions (HSILs) HPV-associated VSCC differentiated neoplasia (dVIN) or acanthosis with altered differentiation HPV-independent VSCC. Although precursors mimicking HSIL described vulva, their frequency morphologic spectrum not...