A5019688305- Cervical Cancer and HPV Research
- Genital Health and Disease
- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Urological Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Hepatitis B Virus Studies
- Global Cancer Incidence and Screening
- Reproductive tract infections research
- AI in cancer detection
- Urologic and reproductive health conditions
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Head and Neck Cancer Studies
- Cancer and Skin Lesions
- Urinary and Genital Oncology Studies
- Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- COVID-19 Impact on Reproduction
- Nonmelanoma Skin Cancer Studies
- Media and Digital Communication
- Cancer-related Molecular Pathways
- Cardiovascular Issues in Pregnancy
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Universitat de Barcelona
2016-2025
Hospital Clínic de Barcelona
2007-2024
Campus Bio Medico University Hospital
2024
Departament de Salut
2024
Barcelona Institute for Global Health
2017-2024
Biomedical Research Institute
2018-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Amsterdam University Medical Centers
2022
American Cancer Society
2022
Objective Using highly sensitive polymerase chain reaction ( PCR ) techniques, we reanalysed all cervical carcinomas CC s) found to be human papillomavirus HPV )‐negative by Hybrid Capture 2 HC 2) determine the prevalence of true ‐negativity. We also evaluated characteristics patients with tumours confirmed Design Observational study. Setting Barcelona, Spain. Population A cohort 136 women (32 adenocarcinomas, 104 squamous cell carcinomas) who had pre‐treatment testing. Methods All negative...
We performed a prospective screening for Trypanosoma cruzi infection in 1350 Latin American pregnant women and their offspring Barcelona, Spain. The rate of seroprevalence was 3.4%, 7.3% the newborns were infected. Routine management programs maternity wards may be warranted.
The expression of p16 is a good surrogate human papillomavirus (HPV) infection in HPV-associated cancers. significance expression, HPV genotype and genera the outcome patients with cervical cancer (CC) unclear. Our aim to ascertain prognostic these factors. Data from 348 (median age: 47.5 years old) CC, diagnosed two referral centers, were retrospectively collected. Advanced disease (FIGO2018 IB2-IV) was present 68% patients. A single identified 82.8% most common HPVs HPV16 (69%) HPV18...
Vulvar intraepithelial neoplasia (VIN) is classified into 2 clinicopathologic subtypes, classic, related to human papillomavirus (HPV) infection and affecting relatively young women, simplex (differentiated), negative for HPV elderly women. Histologically, classic VIN may be basaloid characterized by a replacement of the whole epidermis homogeneous population small, "undifferentiated" keratinocytes, which are diffusely positive p16(INK4a) p53. Simplex atypia basal layer with high degree...
There are at least two different etio‐pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent HPV. We aimed to describe histological characteristics HPV‐associated ‐independent tumors determine best strategy identify HPV in VSCC. A single paraffin block was available review from a series 1,594 VSCCs. In all cases DNA detection analyzed using SPF10PCR/DEIA/LiPA25 system p16...
Widespread adoption of primary human papillomavirus (HPV)‐based screening has encouraged the search for a triage test which retains high sensitivity detection cervical cancer and precancer, but increases specificity to avoid overtreatment. Methylation analysis FAM19A4 miR124‐2 genes shown promise high‐risk (hr) HPV‐positive women. In our study, we assessed consistency / methylation in series 519 invasive carcinomas ( n = 314 scrapes, 205 tissue specimens) from over 25 countries, using...
Background: Recent studies have shown preliminary evidence that vaccination against human papillomavirus (HPV) could decrease the risk of persistent/recurrent HSIL in women treated for high-grade cervical intraepithelial lesion (HSIL). We aimed to determine benefits HPV patients undergoing conization real-life conditions and evaluate compliance associated with different funding policies. Methods: From January 2013 July 2018, 265 underwent our center. 2017, (n = 131) had pay vaccine, whereas...
Introduction Based on their etiological relationship with human papillomavirus (HPV), the 2020 WHO classification has divided vulvar squamous cell carcinomas (VSCC) into two distinct types, HPV‐associated and HPV‐independent, HPV‐independent tumours have recently been according to p53 status. Nevertheless, clinical prognostic significance of this not clearly established. We analysed differential clinical, pathological, behavioural characteristics these three types VSCC in a large series...
Cervical cancer is a leading cause of mortality, with approximately 90% the 250,000 deaths per year occurring in low- and middle-income countries (LMIC). Secondary prevention cervical screening involves detecting treating precursor lesions; however, scaling efforts LMIC has been hampered by infrastructure cost constraints. Recent work supported development an artificial intelligence (AI) pipeline on digital images cervix to achieve accurate reliable diagnosis treatable precancerous lesions....
Introduction: Hugo Robot-Assisted Surgery (RAS) System has been conceived with enhanced modularity but its role for nephron-sparing surgery setting still remains poorly explored. We aimed to describe our experience in robot-assisted partial nephrectomy (RAPN) a three-arms the first off-clamp series using new RAS System. Methods: Patients were placed on an extended flank position at margin of surgical bed slightly flexion (45°). The 11 mm robotic trocar (camera port) was along pararectal line...
Abstract Adolescents are the primary cohort for routine human papillomavirus (HPV) vaccination, but unvaccinated adults may also benefit. A lack of consensus on which to target and presence reimbursement barriers likely contribute lag in adult vaccinations, highlighting missed prevention opportunities. Understanding factors contributing risk HPV infection disease could help decision making vaccination. This review summarizes existing literature includes 153 studies reporting relative risks...
To compare the sensitivity of high-risk human papillomavirus (hrHPV) and genotype detection in self-collected urine samples morning (U1), later on (U2), brush-based self-samples (SS), clinician-taken smears (CTS) for detecting cervical intraepithelial neoplasia grade 2+ (CIN2+) a colposcopic referral population.Cross-sectional single-centre study.A colposcopy clinic Spain.A cohort 113 women referred after an abnormal Pap smear.Women undergoing with biopsy were sent device (Colli-Pee™,...
Aims Experience in the use of whole slide imaging (WSI) for primary diagnosis pathology is very limited. We aimed to determine accuracy interpretation WSI compared with conventional light microscopy (CLM) routine gynaecological biopsies. Methods All specimens (n=452) received over a 2-month period at Department Pathology Hospital Clinic Barcelona were analysed blindly by two pathologists, one using CLM and other WSI. slides digitised Ventana iScan HT (Roche diagnostics) 200×. discrepant...
Penile squamous cell carcinoma (PSCC) is classified into 2 prognostically distinct types: human papillomavirus (HPV)–associated and HPV-independent. However, the impact of p53 status on prognosis remains controversial. We correlated HPV with a large series patients PSCC. was analyzed according to recently described immunohistochemical (IHC) pattern-based framework that includes normal 4 abnormal patterns closely correlates TP53 mutational status. A total 122 surgically treated PSCC in 3...
BACKGROUNDSurgical treatment has modest efficacy for the of infertility associated with early-stage endometriosis. Immunomodulation pentoxifylline is considered as a new strategy potentially useful in treating Thus, this study investigated usefulness combined laparoscopic surgery and therapy minimal to mild