A5055703421- Ovarian cancer diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- DNA and Nucleic Acid Chemistry
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
Humanitas University
2021-2025
IRCCS Humanitas Research Hospital
2021-2025
Mario Negri Institute for Pharmacological Research
2013-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2023
VIB-KU Leuven Center for Cancer Biology
2021
Fondazione IRCCS Istituto Nazionale dei Tumori
2002-2019
Agostino Gemelli University Polyclinic
2005-2019
Candiolo Cancer Institute
2019
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2019
The Christie NHS Foundation Trust
2019
Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered promising targets of novel biological therapies. We previously reported that marine antitumor agent trabectedin, approved Europe 2007 for soft tissue sarcomas 2009 ovarian cancer, was able to downmodulate production selected cytokines/chemokines immune cells. Patients with myxoid liposarcoma (MLS), a subtype characterized by expression oncogenic transcript FUS-CHOP, highly responsive...
Ovarian cancer is a leading cause of deaths among women. Effective targets to treat advanced epithelial ovarian (EOC) and biomarkers predict treatment response are still lacking because the complexity pathways involved in progression. Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression its functional target, Smad7. phosphorylated Smad2 enriched recurrent compared with matched-primary tumours their expression associated shorter time...
Vitamin C promotes anticancer adaptive immunity and enhances efficacy of immune checkpoint therapy.
Abstract Yondelis (Trabectedin) is a novel antitumor agent of marine origin extracted from the tunicate Ecteinascidia turbinata. This original compound active against several human tumors including sarcoma and ovarian breast adenocarcinoma, as evidenced in phase II clinical trials advanced multitreated patients. DNA minor groove binder that blocks cell cycle interferes with inducible gene transcription selective manner. In this study, we investigated immunomodulatory properties on...
Functional telomeres are required for the replicability of cancer cells. The G-rich strand telomeric DNA can fold into a 4-stranded structure known as G-quadruplex (G4), whose stabilization alters telomere function limiting cell growth. Therefore, G4 ligand RHPS4 may possess antitumor activity. Here, we show that triggers rapid and potent damage response at in human transformed fibroblasts melanoma cells, characterized by formation several foci containing phosphorylated factors gamma-H2AX,...
The causes and mechanisms underlying multidrug resistance (MDR) in epilepsy are still elusive may depend on inadequate drug concentration crucial brain areas. We studied whether limbic seizures or anticonvulsant treatments rodents enhance the expression of MDR gene ( mdr ) encoding a permeability glycoprotein (P-gp) involved to various cancer chemotherapeutic agents. also investigated changes P-gp levels affect concentrations brain. Mdr mRNA measured by RT-PCR increased 85% average mouse...
Ecteinascidin-743 (ET-743) is a tetrahydroisoquinoline alkaloid isolated from the tunicate Ecteinascidia turbinata currently under phase II clinical trials for its potent anticancer activity. ET-743 binds DNA in minor groove and forms covalent adducts with some sequence specificity. It selectively inhibits vitro binding of CCAAT box factor NF-Y. In this study, we assayed function vivo on HSP70 promoter. On heat induction, drug blocks transcription rapidly at pharmacological concentrations...
Abstract Differentiation is a complex set of events that can be blocked by rearrangements regulatory genes producing fusion proteins with altered properties. In the case myxoid liposarcoma (MLS) tumors, causative abnormality between CHOP transcription factor and FUS or EWS genes. belongs to negative regulator large CAAT/enhancer binding protein family whose α, β,and δ members are master adipogenesis. Recent clinical data indicate peculiar sensitivity these tumors natural marine compound...
Functional telomeres are required to maintain the replicative ability of cancer cells and represent putative targets for G-quadruplex (G4) ligands. Here, we show that pentacyclic acridinium salt RHPS4, one most effective selective G4 ligands, triggers damages in traversing S phase by interfering with telomere replication. Indeed, found RHPS4 markedly reduced BrdU incorporation at altered dynamic association telomeric proteins TRF1, TRF2 POT1, leading chromosome aberrations such as fusions...