Paolo G. Casali
A5029415642- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Gastrointestinal disorders and treatments
- Oral and Maxillofacial Pathology
- Neurofibromatosis and Schwannoma Cases
- Metastasis and carcinoma case studies
- Platelet Disorders and Treatments
- Soft tissue tumors and treatment
- Musculoskeletal synovial abnormalities and treatments
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Tumors and Oncological Cases
- Economic and Financial Impacts of Cancer
- Cancer-related molecular mechanisms research
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2025
University of Milan
2016-2025
Mylan (Switzerland)
2024
Media Working Group
2024
University Hospital Münster
2022-2023
Hospital Universitario Fundación Jiménez Díaz
2023
European Institute of Oncology
2006-2023
Ripamonti
2022-2023
Hospital Clínico Universitario de Valencia
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2022
Soft tissue sarcomas (STSs) gather over 80 histological entities, with even more molecular subsets, characterised by a low to very incidence in all populations. The majority of arise from the soft (close 75%), ∼15% gastrointestinal stromal tumours (GISTs) and 10% bone sarcomas. These ESMO–EURACAN (European Society for Medical Oncology–European Reference Network rare adult solid cancers) Clinical Practice Guidelines cover STSs, while GISTs are covered dedicated [1.Casali P.G. Abecassis N....
Gastrointestinal stromal tumours (GISTs) are rare tumours, with an estimated unadjusted incidence of around 1/100 000/year [1.Nilsson B. Bümming P. Meis-Kindblom J.M. et al.Gastrointestinal tumors: the incidence, prevalence, clinical course, and prognostication in preimatinib mesylate era–a population-based study western Sweden.Cancer. 2005; 103: 821-829Crossref PubMed Scopus (1027) Google Scholar]. This only covers clinically relevant GISTs, since, if investigated, a much higher number...
The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment recommendations for gastrointestinal stromal tumors (GISTs). standard of practice rapidly changed after the introduction effective molecularly targeted therapy (such as imatinib and sunitinib) GIST. Because these changes, organized multidisciplinary panel composed experts in fields medical oncology, molecular diagnostics, pathology, radiation surgery to discuss optimal approach care patients with GIST at all stages...
PURPOSE The aim of this trial was to compare the activity and toxicity single-agent doxorubicin with that two multidrug regimens in treatment patients adult advanced soft tissue sarcomas. PATIENTS AND METHODS This a prospective randomized phase III performed by 35 cancer centers within Soft Tissue Bone Sarcoma Group European Organization for Research Treatment Cancer (EORTC). Six hundred sixty-three eligible were randomly allocated receive either 75 mg/m2 (arm A), cyclophosphamide,...
Primary bone tumours are rare, accounting for < 0.2% of malignant neoplasms registered in the EUROCARE (European Cancer Registry based study on survival and care cancer patients) database [1.Stiller C.A. Trama A. Serraino D. Descriptive epidemiology sarcomas Europe: report from RARECARE project.Eur J Cancer. 2013; 49: 684-695Abstract Full Text PDF PubMed Scopus (265) Google Scholar]. Different tumour subtypes have distinct patterns incidence, each has no more than 0.3 incident cases per 100...
To explore whether the adoption of a systematic attempt to perform wider resections may lead prognostic improvements in retroperitoneal soft tissue sarcoma (RSTS).Two hundred eighty-eight consecutive patients who were surgically treated at single referral center analyzed. Because shift toward systematic, more aggressive surgical approach (ie, liberal en bloc resection adjacent organs) was place from 2002 onward, divided two groups accordingly. Overall survival, crude cumulative incidence...
Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim this study was to analyze patterns recurrence and treatment variations in a large population patients, treated at reference centers.All consecutive patients with primary RPS 6 European 2 North American institutions between January 2002 December 2011 were included. Five, 8, 10-year overall survival (OS) crude cumulative incidence (CCI) local (LR) distant metastasis (DM) calculated....
incidenceGastrointestinal stromal tumours (GISTs) are rare tumours, with an estimated incidence of 1.5/100 000/year. This only covers the clinically relevant GISTs, since likely a much higher number microscopic lesions could be found pathologically, if looked for.diagnosisWhen small oesophagogastric or duodenal nodules <2 cm in size detected, endoscopic biopsy may difficult, and laparoscopic/laparotomic excision way to get histological diagnosis. Many these nodules, diagnosed as GIST, will...
The authors explored the prognostic factors and clinical outcomes of patients who had malignant peripheral nerve sheath tumors (MPNST) with without neurofibromatosis type 1 (NF-1).Two hundred five localized MPNST underwent surgery at Istituto Nazionale per lo Studio e la Cura dei Tumori (Milan, Italy) over 25 years were reviewed. Forty-six concomitant NF-1 syndrome, 159 did not. Local recurrence, distant metastases, survival rates studied.One thirty presented primary disease, 75 locally...
Abstract BACKGROUND The optimal treatment strategy for synovial sarcoma (SS) is subject to debate, and different strategies have been used pediatric adult patients. current retrospective analysis examined a large group of patients all ages who were treated at single institution over 30‐year period. METHODS study included 271 ranged in age from 5 years 87 years; 255 had localized disease, which was macroscopically resected 215 cases deemed unresectable diagnosis 40 cases. Chemotherapy...