A5020231396- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Neonatal Health and Biochemistry
- SARS-CoV-2 and COVID-19 Research
- Toxoplasma gondii Research Studies
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Prenatal Screening and Diagnostics
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Viral-associated cancers and disorders
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Helicobacter pylori-related gastroenterology studies
- Transplantation: Methods and Outcomes
- Blood groups and transfusion
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Bacterial Infections and Vaccines
- Systemic Lupus Erythematosus Research
University of Bologna
2016-2025
Azienda USL di Bologna
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Policlinico S.Orsola-Malpighi
2014-2023
Fundación Juan March
2017
Prince of Wales Hospital
2015
UNSW Sydney
2015
University of California, San Francisco
2015
ASM International
2015
New South Wales Department of Health
2015
Congenital infection with human cytomegalovirus (CMV) is a major cause of morbidity and mortality. In an uncontrolled study published in 2005, administration CMV-specific hyperimmune globulin to pregnant women primary CMV significantly reduced the rate intrauterine transmission, from 40% 16%.We evaluated efficacy phase 2, randomized, placebo-controlled, double-blind study. A total 124 at 5 26 weeks gestation were randomly assigned within 6 after presumed onset receive or placebo every 4...
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis <1% of infected individuals. We show that ∼35% patients hospitalized for WNV disease (WNVD) six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence these antibodies highest with (∼40%), silent as low general population. odds ratios WNVD relative to those without them population range 19.0 (95% CI 15.0–24.0, P value <10–15) only...
Lack of specific definitions clinical characteristics, disease severity, and risk preventive factors post-COVID-19 syndrome (PCS) severely impacts research discovery new therapeutics drugs.This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- in-patients followed at 3-, 6-, 12-month diagnosis, with assessment biochemical features, antibody (Ab) response, Variant Concern (VoC), physical mental quality life (QoL)....
Human cytomegalovirus (CMV) is a ubiquitous human-specific DNA virus and the main cause of congenital infection in developed countries leading to psychomotor impairment deafness. Diagnostic techniques for CMV detection have greatly improved during recent years with advent sophisticated serological virological methods. The aim present study was assess diagnostic prognostic value quantification neonatal blood samples symptomatic asymptomatic newborns infection.Between January 1997 December...
Abstract Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes hematopoietic stem cell transplant (HSCT) solid organ (SOT; heart, kidney, or liver) in Europe. collected electronic data on the population guidelines/regulations clinical cases diagnosed during 2010–2014. Serologic pretransplant screening allo-hematopoietic donors was performed 80% countries, 100%. SOT...
Variability in the performance of nucleic acid amplification technology (NAT)-based assays presents a significant problem diagnosis and management human cytomegalovirus (HCMV) infections. Here we describe collaborative study to evaluate suitability candidate reference materials harmonize HCMV viral load measurements wide range NAT assays. Candidate comprised lyophilized Merlin virus, liquid AD169 purified DNA cloned into bacterial artificial chromosome. laboratory mean concentrations...
Abstract Italy was the first European nation to be massively infected by SARS‐CoV‐2. Up end of May 2020, more than 33,000 deaths had been recorded in Italy, with a large prevalence among males, those over 75 years age, and association co‐morbidities. We describe lung pathological immunohistochemical post‐mortem findings at autopsy nine patients who died SARS‐CoV‐2‐associated disease. found tissues all histological changes consistent diffuse alveolar damage various evolution phases ranging...
Despite global vaccination efforts, immunocompromized patients remain at high risk for COVID-19-associated morbidity. In particular, with impaired humoral immunity have shown a of persistent infection. We report case series adult B cell malignancies and/or undergoing targeting therapies persisting SARS-CoV-2 infection and treated combination antiviral therapy remdesivir nirmatrelvir/ritonavir, in three Italian tertiary academic hospitals. A total 14 adaptive prolonged were the dual therapy....
Although several conditions and specific risk factors have been associated with stillbirth (SB), in most of the cases it is difficult to identify definitive etiopathology cause death. Specifically, role infections SB still debated. Our aim was study maternal, placental, fetal tissues order define causative link between death, through a multidisciplinary clinical audit. Between 2014 2022, microbiological investigations on placental samples were performed according standardized protocol...