A5050542608- Systemic Lupus Erythematosus Research
- Aortic Disease and Treatment Approaches
- Renal Diseases and Glomerulopathies
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Aortic aneurysm repair treatments
- Chemokine receptors and signaling
- Cardiovascular Health and Disease Prevention
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Clinical Research Studies
- Vascular Procedures and Complications
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Protein Tyrosine Phosphatases
- Venous Thromboembolism Diagnosis and Management
- Vasculitis and related conditions
- Infectious Aortic and Vascular Conditions
- Peripheral Artery Disease Management
- Connective tissue disorders research
- Peptidase Inhibition and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Diabetes and associated disorders
Sapienza University of Rome
2014-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2025
Azienda Ospedaliera Sant'Andrea
2010-2022
European University of Rome
2022
Medicina
2016
University of Bari Aldo Moro
2003
Objective. The aim of our study was to evaluate the lymphocyte subpopulations and cytokines in peripheral blood patients with type-A Stanford acute aortic dissection (AAD group) determine whether inflammatory cells are present at site dissection.Methods. Thirty-five consecutive were evaluated for haemochrome (CD3+, CD4+, CD8+, CD19+, CD4+CD25+, CD16+CD56+, CD4+CD28−, CD8+CD28−) by flow cytometry. C-reactive protein (CRP), tumour necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6, IL-8,...
Objectives. To determine whether tumour necrosis factor (TNF)-α blockers may reduce carotid intima-media thickness (cIMT) in patients with active rheumatoid arthritis (RA) steadily responsive to such therapy. Methods. From 287 consecutive RA attending our out-patient clinic and diagnosed on the basis of American College Rheumatology (ACR) criteria, 49 without traditional cardiovascular risk factors meeting requirements for TNF-α therapy were selected. Among them, 39 actually started...
The authors assessed the prevalence of neuropsychiatric manifestations occurring in patients with systemic lupus erythematosus (NPSLE), according to American College Rheumatology standardized definitions for NPSLE, and evaluated relationship between NPSLE antiphospholipid antibodies. Sixty-one consecutive SLE were studied. Neuropsychiatric consistent diagnosis occurred 44 (72%). Patients showed significantly higher levels anticardiolipin
<b><i>Objectives:</i></b> The aim of the study was to determine whether release by macrophages matrix metalloproteinase (MMP)-12 and vascular endothelial growth factor (VEGF) - leading inflammation, degradation neoangiogenesis represents an effective pathway that underlies aortic wall remodeling in Stanford type A acute dissection (AAD). <b><i>Methods:</i></b> Twenty-one consecutive patients with no genetic predisposition, AAD were selected. In...
Objective: The neutrophil–lymphocyte ratio (NLR) is an inexpensive and easily available inflammatory marker for cardiovascular disease. aim of the present study to evaluate a possible association between preoperative NLR value popliteal artery aneurysm (PAA) repair outcomes. Methods: A single-center retrospective on all patients, who underwent urgent or elective PAA from June 2010 October 2022, was performed. Study outcomes were immediate technical success, 30-day mid-term primary patency,...
To investigate the thrombotic tendency in patients with systemic lupus erythematosus (SLE) by evaluating congenital or acquired abnormalities associated an increased risk of venous and/or arterial thrombosis.A total 57 SLE were included study. Twenty-one (37%) had a history thrombosis and 36 (63%) did not have such history. Sera from 50 healthy controls examined. Protein C, protein S, antithrombin, D-dimer, fibrinogen, homocysteine, anticardiolipin antibodies (aCL), anticoagulant (LAC),...
Acute limb ischemia (ALI), classified according to Rutherford's classification (RC), is a vascular emergency burdened by high rates of mortality and morbidity. The need new different prognostic values for ALI has emerged, and, among all, the neutrophil-to-lymphocyte ratio (NLR) been proven as strong outcome predictor in disease. aim this study investigate role preoperative NLR predicting clinical outcomes patients presenting acute ischemia.A single-center retrospective was conducted between...
Lockdowns imposed by governments worldwide as a way to limit the spread of severe atypical respiratory syndrome-coronavirus-2 (SARS-CoV2) have had heavy psychological and economic consequences. Arthritis patients are vulnerable population at an increased risk peritraumatic stress. This could be due several reasons, including fear shortage medicine difficulty receiving periodical medical checks. In present case-control study, distress in with autoimmune arthritis during coronavirus disease...
The study evaluated macrophage cytokines and metalloprotease (MMP)-12 levels in patients with Stanford-A acute aortic dissection (AAD) critical carotid artery stenosis (CAS) compared matched for age, sex, traditional cardiovascular risk factors (RF). aim was to identify possible early serum markers of atherosclerotic complications.We selected 65 patients: 23 AAD patients, 21 CAS RF, 10 healthy subjects (HS). In each patient control serum, interleukin (IL)-6, IL-8, tumour necrosis factor...
COVID-19 is a respiratory tract infection caused by the new coronavirus SARS-COV2 that can be complicated acute distress syndrome and multiorgan failure. In light of high rate mortality associated with COVID-19, pharmacological non-pharmacological strategies to prevent are currently being tested. Among preventive measures, vaccines represent one main resources for public health. It has been suggested Bacille Calmette-Guérin (BCG) vaccine may protect individuals against from virus, two...
Monocytes are a heterogeneous cell population distinguished into three subsets with distinctive phenotypic and functional properties: "classical" (CD14++CD16-), "intermediate" (CD14++CD16+), "nonclassical" (CD14+CD16++). Monocyte play pivotal role in many inflammatory systemic diseases including atherosclerosis (ATS). Only low number of studies evaluated monocyte behavior patients affected by cardiovascular diseases, data about their acute aortic dissection (AAD) lacking. Thus, the aim this...
Objective The aim of our study was to evaluate obstetric outcome women affected by idiopathic infertility showing persistently positive antiphospholipid antibodies (aPL). Methods : From 2000 consecutive patients undergoing ART, we selected 151 (7.55%) clinical records ICSI and aPL. Results Persistently aPL were found in 64/151 (42.38%) the patients: 34/64 (53.12%) at medium/high titers (group A) 30/64 (46.87%) low B). Primary or secondary syndrome (APS) diagnosed 25% patients, whereas 37.5%...
Abstract: Twenty consecutive rheumatoid arthritis (RA) patients (mean age 50.4 ± 10.5 years; 17 females; mean disease duration 5.78 3.75 years) enrolled for tumor necrosis factor‐α (TNF‐α) blockers therapy (10 infliximab and 10 etanercept) were selected. Before starting therapy, 3 6 months thereafter all evaluated activity score (DAS), erythrocyte sedimentation rate (ESR), serum levels of C‐reactive protein (CRP), interleukin‐6 (IL‐6), nerve growth factor (NGF), brain‐derived neurotrophic...
Atherosclerosis is a multifactorial disease characterized by an immune-inflammatory remodeling of the arterial wall. Treg and Th17 subpopulations are detectable inside atherosclerotic plaque; however, their behavior in symptomatic carotid artery stenosis (CAS) not fully elucidated. The aim this study was to evaluate subsets ratio patients affected asymptomatic CAS.14 with CAS (CAS-S group), 41 (CAS-A 32 subjects traditional cardiovascular risk factors (RF 10 healthy (HS group) were enrolled....
Castleman disease (CD) comprises a group of rare and heterogeneous haematological disorders, including unicentric (UCD) multicentric (MCD) forms, the latter further subdivided into HHV8-MCD, POEMS-MCD idiopathic-MCD (iMCD). However, according to Disease Collaborative Network guidelines, diagnosis CD can only be achieved through collaboration between clinicians pathologists.
Although numerous studies concern fibrinogen (FBG) associations, the relationship between platelet (PLT) count and FBG plasma levels has yet to be completely investigated. The present study concerns association PLT in 5891 patients (2831 men 3060 women) attending our outpatients' laboratory. Of these, a subgroup of 4116 (1899 2217 with normal values parameters investigated was selected. A group 170 coronary heart disease also included. studied were FBG, count, leukocyte age. Our results...