A5041026962- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Eosinophilic Disorders and Syndromes
- Histiocytic Disorders and Treatments
- Cellular transport and secretion
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Stroke Rehabilitation and Recovery
- Medical Imaging Techniques and Applications
- Vestibular and auditory disorders
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Ophthalmology and Eye Disorders
- Alzheimer's disease research and treatments
- Genital Health and Disease
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myeloid Leukemia Research
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Brain Metastases and Treatment
- Retinal Development and Disorders
- Adenosine and Purinergic Signaling
LMU Klinikum
2022-2025
Ludwig-Maximilians-Universität München
2021-2025
Klinik und Poliklinik für Nuklearmedizin
2022-2025
München Klinik
2022-2025
Policlinico Umberto I
2018-2023
Sapienza University of Rome
2003-2023
Ospedale Valduce
2009-2022
Villa Melitta
2020
MUNDUS is an assistive framework for recovering direct interaction capability of severely motor impaired people based on arm reaching and hand functions. It aims at achieving personalization, modularity maximization the user’s involvement in systems. To this, exploits any residual control end-user can be adapted to level severity or progression disease allowing user voluntarily interact with environment. target pathologies are high-level spinal cord injury (SCI) neurodegenerative genetic...
Parkinson's disease (PD) often leads to multifactorial motor and non-motor disabilities with resultant social restrictions. Continuity of care in this pathology, including a tailored home rehabilitation, is crucial improve or maintain the quality life for patients. The aim multicenter study was test pilot sample PD patients efficiency efficacy Human Empowerment Aging Disability (HEAD) program. virtual reality HEAD program administered two consecutive phases: (1) clinic (ClinicHEAD, 12...
Polycythemia vera (PV) and essential thrombocythemia (ET) can present in pediatric age as sporadic or familial diseases. To define the biologic profile of childhood PV ET, we evaluated specific markers a cohort patients affected by including cases with occurrence.Thirty-eight children ET were investigated. The control group included 58 adults ET. Endogenous erythroid colonies, qualitative reverse transcriptase polymerase chain reaction for polycythemia rubra vera-1 (PRV-1) RNA expression,...
Background The recent exponential growth of Digital Health (DH) in the healthcare system provides a crucial transformation healthcare, answering to alarming threats related increasing number Chronic Neurological Diseases (CNDs). New long-term integrated DH-care approaches, including rehabilitation, are warranted address these concerns. Methods Human Empowerment Aging and Disability (HEAD) rehabilitation program, new care system, was evaluated terms efficiency patient-reported outcome...
Microglia, the innate immune cells of central nervous system (CNS), act as first responders in context brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a role maintaining homeostasis. Recently, P2Y12 receptor (P2Y12R) has been identified promising molecular biomarker for microglia, its expression level is directly dependent on microglia phenotype function. A decline P2Y12R indicative damage, microglial malfunction...
Microglia, the innate immune cells of central nervous system (CNS), act as first responders in context brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a role maintaining homeostasis. Recently, P2Y12 receptor (P2Y12R) has been identified promising molecular biomarker for microglia, its expression level is directly dependent on microglia phenotype function. A decline P2Y12R indicative damage, microglial malfunction...
Ziel/Aim: Für eine zuverlässige Quantifizierung von Aktivitätsverteilungen in der Positronen-Emissions-Tomographie (PET) werden Validierungsmessungen mit radioaktiven Phantomen durchgeführt. Es hat sich gezeigt, dass radioaktive 3D-gedruckte Phantome Vorteile gegenüber herkömmlichen füllbaren haben. Wichtig ist hierbei, die Aktivität gleichmäßig im gedruckten Material verteilt ist. Ziel dieser Arbeit war es, verschiedene Harze, Misch- und Drucktechniken zu untersuchen, um festzustellen, was...
Ziel/Aim: Alzheimer-Demenz (AD) zeichnet sich durch Ablagerungen von Amyloid-β (Aβ) Plaques, Neuroinflammation und Neurodegeneration aus. Frühere Studien zeigten, dass der ein Hypermetabolismus eine Hyperexzitabilität Neuronen vorausgehen. Diese Studie untersucht den zeitlichen räumlichen Zusammenhang Aβ Plaque-Akkumulation, Sv2a-Expression in einem Amyloid-Mausmodell.
Ziel/Aim: [18F]D2-Deprenyl bindet an das Enzym MAO-B und ermöglicht so Rückschlüsse auf die Aktivität von Astrozyten, als Index der Neuroinflammation im ZNS. Bislang wurde [18F]D2-Deprenyl-PET vor allem zur Untersuchung neurodegenerativen Erkrankungen wie Alzheimer ALS eingesetzt. Glioblastome sind häufigsten primären Hirntumore. Da sie entarteten Astrozyten ausgehen könnte eine Bildgebung durch auch hier Nutzen sein, jedoch Erfassung dienen.
Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks Alzheimer's disease. Here, we aimed to investigate temporal spatial association between synaptic activity, Aβ plaque load, in an mouse model with limited neurodegeneration. 26 APPSL70 15 C57Bl/6 mice underwent longitudinal PET-scans [18F]UCB-H from onset levels strong load (5.3 - 11.0 months age) assess vesicle protein 2A (SV2A) expression, [18F]FBB determine fibrillar [18F]GE-180...
β-amyloid (Aβ) small animal PET facilitates quantification of fibrillar amyloidosis in Alzheimer's disease (AD) mouse models. Thus, the methodology is receiving growing interest as a monitoring tool preclinical drug trials. In this regard, harmonization data from different scanners at multiple sites would allow establishment large collaborative cohorts and may facilitate efficacy comparison treatments. Therefore, we objected to determine level agreement Aβ-PET by head-to-head three...
Gaucher disease (GD) has been increasingly recognized as a continuum of phenotypes with variable neurological and sensory involvement. No study yet specifically explored the spectrum neuropsychiatric abnormalities in GD patients through multidisciplinary approach. Abnormalities involving nervous system, including abnormalities, cognitive disturbances, psychiatric comorbidities, have identified GD1 GD3 patients. In this prospective study, named SENOPRO, we performed neurological,...
Castleman disease (CD) comprises a group of rare and heterogeneous haematological disorders, including unicentric (UCD) multicentric (MCD) forms, the latter further subdivided into HHV8-MCD, POEMS-MCD idiopathic-MCD (iMCD). However, according to Disease Collaborative Network guidelines, diagnosis CD can only be achieved through collaboration between clinicians pathologists.
Peripheral blood stem cells (PBSC) are widely used in the setting of dose-intensive chemotherapies patients with multiple myeloma (MM). Although granulocyte colony-stimulating factor (G-CSF), following chemotherapy or not, is considered standard growth for mobilizing PBSC, optimal chemotherapeutic regimen still remains to be defined. Cyclophosphamide (CTX) an effective drug treatment MM which capable PBSC if followed by factors, even though administration high-dose CTX (7...
Langerhans cell histiocytosis (LCH) is a rare disease due to clonal proliferation of myeloid precursors that differentiate in CD1a+/CD207+ lesions. More frequent children than adults, it can occur at any age with various degrees systemic involvement. Among the large landscape clinical manifestations, bone involvement represents commonest single organ involved LCH. Many different therapeutic strategies have been used for LCH.1, 2 less toxic and more effective regimens, indomethacin was found...
This paper addresses the results of instrument and product performance verification, radiometric geometric calibration achieved during since commissioning routine phase.
Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets help pharmaceutical research development new drugs and attempt early diagnosis that can contribute improving people's quality life. There are several advantages enriching longitudinal AD with Positron Emission Tomography (PET); among these advantages, possibility following principle 3Rs animal welfare is fundamental. In this manuscript, good...
Abstract Neuronal lesions trigger mechanisms of structural and functional neuroplasticity, which can support recovery. However, the temporal spatial appearance structure–function changes their interrelation remain unclear. The current study aimed to directly compare serial whole-brain in vivo measurements plasticity (by [ 18 F]FDG-PET) synaptic F]UCB-H-PET) before after bilateral labyrinthectomy rats investigate effect locomotor training. Complex were found labyrinthectomy:...
During the last 15 years, we have used National Cancer Institute (NCI) 89-C-41 protocol in patients aged younger than 21 years with Burkitt's leukemia/lymphoma (BLL) and diffuse large B-cell lymphoma (DLBCL). According to Magrath staging system, were classified as low high risk. Low-risk received three cycles of CODOX-M regimen; high-risk four alternating IVAC regimens. Thirty-five entered study: 32 (91%) achieved complete remission (CR); non-responders died one patient CR. Two responders...
Aggregating poly(glycine-alanine) (poly-GA) is derived from the unconventional translation of pathogenic intronic hexanucleotide repeat expansion in C9orf72 gene, which most common genetic cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly-GA accumulates predominantly neuronal cytoplasmic inclusions unique to ALS/FTD patients. is, therefore, a promising target for PET/CT imaging FTD/ALS monitor disease progression therapeutic interventions. A novel 64Cu-labeled...
Technical devices have become an indispensable part of our everyday life and they also been used in rehabilitation for decades with increasing potential through technological advancement. In rehabilitation, however, many disabilities like stroke or dementia are more likely age, especially the older generation is often described as being sceptic afraid technology. When developing implementing new technology, this needs to be considered discriminated against disease related difficulties when...