A5065068777- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Prosthetics and Rehabilitation Robotics
- EEG and Brain-Computer Interfaces
- Knee injuries and reconstruction techniques
- Spinal Cord Injury Research
- Tendon Structure and Treatment
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neural Engineering
- Balance, Gait, and Falls Prevention
- Transcranial Magnetic Stimulation Studies
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Gaze Tracking and Assistive Technology
- Human Pose and Action Recognition
- Soft Robotics and Applications
- Robot Manipulation and Learning
- Telemedicine and Telehealth Implementation
- Osteoarthritis Treatment and Mechanisms
- Context-Aware Activity Recognition Systems
- Robotic Mechanisms and Dynamics
- Botulinum Toxin and Related Neurological Disorders
- Orthopaedic implants and arthroplasty
- Assistive Technology in Communication and Mobility
Politecnico di Milano
2016-2025
Ally Therapeutics (United States)
2024
Bioengineering Technology and Systems (Italy)
2016
Anterior cruciate ligament (ACL) reconstruction restores knee stability but does not reduce the incidence of posttraumatic osteoarthritis induced by inflammatory cytokines. The aim this research was to longitudinally measure IL-1 β , IL-6, IL-8, IL-10, and TNF- α levels in patients subjected ACL using bone-patellar tendon-bone graft. Synovial fluid collected within 24–72 hours rupture ( acute ), 1 month after injury immediately prior surgery presurgery thereafter postsurgery ). For...
The treatment of anterior cruciate ligament (ACL) injuries in children and adolescents is challenging. Preclinical clinical studies investigated ACL repairing techniques skeletally immature subjects. However, intra-articular bioenvironment following tear has not yet been defined patients. aim this study was to measure cytokine concentrations the synovial fluid adolescent population. Synovial levels IL-1β, IL-1ra, IL-6, IL-8, IL-10, TNF-α were measured 17 patients (15 boys) with tears who...
Abstract Surgical reconstruction of the anterior cruciate ligament (ACL) does not necessarily decrease risk developing osteoarthritis (OA). The inflammatory response and relative changes in pro‐ anti‐inflammatory cytokines could participate triggering development OA. To test this hypothesis we measured concentrations IL‐1β, IL‐1ra, IL‐6, IL‐8, IL‐10, TNF‐α at different times after ACL rupture. sample population consisted 48 patients with tear which were assigned to groups according time...
MUNDUS is an assistive framework for recovering direct interaction capability of severely motor impaired people based on arm reaching and hand functions. It aims at achieving personalization, modularity maximization the user’s involvement in systems. To this, exploits any residual control end-user can be adapted to level severity or progression disease allowing user voluntarily interact with environment. target pathologies are high-level spinal cord injury (SCI) neurodegenerative genetic...
Nowadays, work-related musculoskeletal disorders have a drastic impact on large part of the world population. In particular, low-back pain counts as leading cause absence from work in industrial sector. Robotic exoskeletons great potential to improve workers' health and life quality. Nonetheless, current solutions are often limited by sub-optimal control systems. Due dynamic environment which they used, failure adapt wearer task may be limiting exoskeleton adoption occupational scenarios....
Spinal cord injuries (SCI) often lead to upper limb impairment, necessitating innovative solutions for daily assistance beyond traditional rigid robotics due their impractical weight and size. Despite still preliminary, soft wearables are arising as a possible solution fill this gap. Here, we demonstrated an enhanced version of inflatable robot that assists the shoulder against gravity, previously tested with different neurological conditions. Noteworthy improvements include single-layer...
Abstract Exoskeletons for rehabilitation can help enhance motor recovery in individuals suffering from neurological disorders. Precision movement execution, especially arm rehabilitation, is crucial to prevent maladaptive plasticity. However, current exoskeletons, while providing support, often lack the necessary 3D feedback capabilities show how well exercises are being performed. This reduces therapist acceptance and patients’ performance. Augmented Reality technologies offer promising...
The standard account of motor control considers descending outputs from primary cortex (M1) as commands and efference copy. This has been challenged recently by an alternative formulation in terms active inference: M1 is considered part a sensorimotor hierarchy providing top-down proprioceptive predictions. key difference between these accounts that predictions are sensitive to the current context, whereas copy not. Using functional electric stimulation experimentally manipulate...
Objective To design and implement an electromyography (EMG)-based controller for a hand robotic assistive device, which is able to classify the user's motion intention before effective kinematic movement execution. Methods Multiple degrees-of-freedom grasp movements (i.e. pinching, object, grasping) were predicted by means of surface EMG signals, recorded from 10 bipolar electrodes arranged in circular configuration around forearm 2-3 cm elbow. Two cascaded artificial neural networks then...
In this work, we introduce the AGREE exoskeleton, a robotic device designed to assist in upper-limb physical rehabilitation for post-stroke survivors. We detail exoskeleton design at mechatronic, actuation, and control levels. The features lightweight adaptable mechanical design, which can be used with both right left arm, supporting three active degrees-of-freedom shoulder one elbow. embodies spring-pulley anti-gravity system minimize torque requirements has sensors on each joint safe...
Over the last few years, exoskeletons have been demonstrated to be useful tools for supporting execution of neuromotor rehabilitation sessions. However, they are still not very present in hospitals. Therapists tend wary this type technology, thus reducing its acceptability and, therefore, everyday use clinical practice. The work presented paper investigates a novel point view that is different from patients, which normally what considered similar analyses. Through realization technology...
ABSTRACT Concentrations of pro‐ and anti‐inflammatory cytokines in synovial fluid samples collected from patients with chronic meniscal tears were investigated. An acute inflammatory response is generally reported 24–48 h after knee injury, but the largest body data available literature concerns anterior cruciate ligament injury very little information about balance soluble factors knees tears. Sixty‐nine (46 males 23 females) tear that occurred more than 3 months earlier enrolled. According...
Two key ingredients of a successful neuro-rehabilitative intervention have been identified as intensive and repetitive training subject's active participation, which can be coupled in an robot-assisted training. To exploit these two elements, we recorded electroencephalography, electromyography kinematics signals from nine healthy subjects performing 2×2 factorial design protocol, with volitional intention robotic glove assistance factors. We quantitatively evaluated primary sensorimotor,...
Neurorehabilitation effective delivery for stroke is likely to be improved by establishing a mechanistic understanding of how enhance adaptive plasticity. Functional electrical stimulation at reducing poststroke foot drop; in some patients, the effect persists after therapy has finished with an unknown mechanism. We used fMRI examine neural correlates functional key elements, volitional intent move and concurrent stimulation, group chronic patients receiving foot-drop correction. Patients...
This manuscript presents an updated review of back exoskeletons for occupational use, with a particular focus on sensor technology as key enabler intelligent and adaptive support. The study aims to identify barriers adoption explore design characteristics which align these systems the Industry 5.0 paradigm, where machines function collaborative co-pilots alongside humans. We propose structured pipeline analyze 32 across multiple dimensions, including design, actuation, control strategies,...
Stroke-related locomotor impairments are often associated with abnormal timing and intensity of recruitment the affected non-affected lower limb muscles. Restoring proper limbs muscles activation is a key factor to facilitate recovery gait capacity performance, reduce maladaptive plasticity. Ekso wearable powered exoskeleton robot able support over-ground training. The user controls by triggering each single step during cycle. fine-tuning control system crucial-it set according residual...
Aquatic exercises have been demonstrated to benefit the facilitation of motor recovery and enhancement well-being in middle-aged adults elderly. Personalization, immersiveness, biofeedback are key for amplifying accelerating any rehabilitation process neurological orthopedic patients. However, a therapist can neither properly visualize nor monitor executed under water, he/she measure them. Therefore, this paper aims provide adaptive during aquatic order enhance training's effectiveness. A...
Over the past several years, electromyography (EMG) signals have been used as a natural interface to interact with computers and machines. Recently, deep learning algorithms such Convolutional Neural Networks (CNNs) gained interest for decoding hand movement intention from EMG signals. However, networks require large dataset train appropriately. Creating database single subject could be very time-consuming. In this study, we addressed issue two perspectives: (i) proposed subject-transfer...
Within the European project MUNDUS, an assistive framework was developed for support of arm and hand functions during daily life activities in severely impaired people. This contribution aims at designing a feedback control system Neuro-Muscular Electrical Stimulation (NMES) to enable reaching people with no residual voluntary shoulder due high level spinal cord injury. NMES is applied deltoids biceps muscles integrated three degrees freedom (DoFs) passive exoskeleton, which partially...