A5023361737- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- High Altitude and Hypoxia
- Exercise and Physiological Responses
- Receptor Mechanisms and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Stroke Rehabilitation and Recovery
- Neuroscience of respiration and sleep
- Transplantation: Methods and Outcomes
- Cannabis and Cannabinoid Research
- Heme Oxygenase-1 and Carbon Monoxide
- Dementia and Cognitive Impairment Research
- Celiac Disease Research and Management
- Cardiovascular and exercise physiology
- Inflammatory mediators and NSAID effects
- Cardiovascular and Diving-Related Complications
- Tissue Engineering and Regenerative Medicine
- Tryptophan and brain disorders
- Fetal and Pediatric Neurological Disorders
- Extracellular vesicles in disease
- Occupational and environmental lung diseases
- COVID-19 diagnosis using AI
- Pharmacological Receptor Mechanisms and Effects
- Telomeres, Telomerase, and Senescence
- Parkinson's Disease Mechanisms and Treatments
National Research Council
2016-2023
University of Milan
2010-2020
Institute of Molecular Bioimaging and Physiology
2015-2019
National Academies of Sciences, Engineering, and Medicine
2015-2016
University of Pisa
2010
Agostino Gemelli University Polyclinic
2007
Abstract Surgical reconstruction of the anterior cruciate ligament (ACL) does not necessarily decrease risk developing osteoarthritis (OA). The inflammatory response and relative changes in pro‐ anti‐inflammatory cytokines could participate triggering development OA. To test this hypothesis we measured concentrations IL‐1β, IL‐1ra, IL‐6, IL‐8, IL‐10, TNF‐α at different times after ACL rupture. sample population consisted 48 patients with tear which were assigned to groups according time...
There is a pressing demand for improving the quality and efficacy of health care social support services needed by world's growing elderly population, especially those affected mild cognitive impairment (MCI) Alzheimer's disease. Exercise has been demonstrated to mitigate oxidative stress (OxS) that recognized as contributing factor in progression multiple neurodegenerative diseases. Meeting innovative addressed specific needs treatment area mitigation rehabilitation, main objective this...
Aiming to gain a detailed insight into the physiological mechanisms involved under extreme conditions, group of experienced ultra-marathon runners, performing mountain Tor des Géants® ultra-marathon: 330 km trail-run in Valle d'Aosta, 24000 m positive and negative elevation changes, was monitored. ROS production rate, antioxidant capacity, oxidative damage inflammation markers were assessed, adopting micro-invasive analytic techniques.Forty-six male athletes (45.04±8.75 yr, 72.6±8.4 kg,...
Telomere shortening is considered a cellular marker of health status and biological ageing. Exercise may influence the lifespan an individual by affecting telomere length (TL). However, it unclear whether different endurance exercise levels have beneficial or detrimental effects on aging. The aims study were to assess both chronic acute training TL after exceptional extreme trail race. was assessed in 20 athletes (17 males; age = 45.4 ± 9.2 years) 42 age- gender-matched sedentary controls...
Purpose. Response to an ultraendurance competitive race on thiols redox status, reactive oxygen species (ROS) production, and oxidative stress (OxS) was investigated according duration. Methods. Twenty-four elite runners were examined: six completed 50 km eighteen 100 km. Blood urine samples collected before immediately after the race. Erythrocytes plasma aminothiols by high-performance liquid chromatography, total antioxidant capacity (TAC), OxS biomarkers (protein carbonyl (PC),...
Introduction: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) tissue injury in different intestinal extra conditions, including celiac disease (CD). The aim the present study was investigate role potential use ROS other biomarkers OxS clinical management CD. Methods: We collected duodenal specimens blood samples from naïve patients (N-CD), on a gluten free diet (GFD) responders (CD-GFD) non-responders (NRCD).We measured...
Background and Purpose Chemokines are involved in neuroinflammation contribute to chronic pain processing. The new chemokine prokineticin 2 ( PROK2 ) its receptors PKR 1 have a role inflammatory immunomodulation. In the present study, we investigated involvement of neuropathic pain. Experimental Approach Effects single, intrathecal, perineural s.c. injections antagonist PC1 , or week treatment, on thermal hyperalgesia tactile allodynia was evaluated mice with constriction sciatic nerve CCI...
Abstract High altitude is the most intriguing natural laboratory to study human physiological response hypoxic conditions. In this study, we investigated changes in reactive oxygen species (ROS) and oxidative stress biomarkers during exposure hypobaric hypoxia 16 lowlanders. Moreover, looked at potential relationship between ROS related cellular damage optic nerve sheath diameter (ONSD) as an indirect measurement of intracranial pressure. Baseline clinical signs symptoms, biological samples...
Abstract High altitude is a natural laboratory, within which the clinical study of human physiological response to hypobaric hypoxia (HH) possible. Failure in results progressive hypoxemia, inflammation and increased tissue oxidative stress (OxS). Thus, investigating temporal changes key transcription factors (TFs) HIF-1α , HIF-2α NF-κB NRF2 mRNA levels, relative OxS inflammatory markers, may reveal molecular targets contrast deleterious effects hypoxia. Biological samples data from 15...
Introduction: Hyperbaric oxygen (HBO2) therapy and use of enriched air can result in oxidative injury affecting the brain, lungs eyes. HBO2 exposure during diving lead to a decrease respiratory parameters. However, possible effects acute oxygen-enriched on subsequent spiro- metric performance state humans have not been recently described recently. We aim investigate (i) hyperbaric (ii) hyperoxic using scuba or closed-circuit rebreather (CCR) spirometry assess role after diving. Methods:...
Malignant pleural mesothelioma (MPM) is an aggressive tumor characterized by poor prognosis. Its incidence steadily increasing due to widespread asbestos exposure. There still no effective therapy for MPM. Pemetrexed (Pe) one of the few chemotherapeutic agents approved advanced-stage disease, although objective response drug limited. The use gold nanoparticles (GNPs) as a delivery system promises several advantages, including specific targeting malignant cells, with increased intracellular...
Celecoxib, diclofenac, ibuprofen, and nimesulide are nonsteroidal anti-inflammatory drugs (NSAIDs) very commonly used for the treatment of moderate to mild pain, together with paracetamol (acetaminophen), a widely analgesic lesser effect. In study reported here, we tested efficacy celecoxib, ibuprofen on preprotachykinin mRNA synthesis, substance P (SP) release, prostaglandin E(2) (PGE(2)) protein kinase C epsilon (PKCɛ) translocation in rat cultured sensory neurons from dorsal root ganglia...
Abstract Marijuana abuse is prominent among adolescents. Although Δ9-THC, one of its main components, has been demonstrated to modulate immunity in adults, little known about impact during adolescence on the immune system and long-lasting effects adulthood. We demonstrate that 10 days Δ9-THC treatment induced a similar alteration macrophage splenocyte cytokines adolescent adult mice. Immediately at end chronic decrease proinflammatory IL- 1β TNF-α an increase anti-inflammatory cytokine IL-10...
Chronic alcohol use has profound modulatory effects on the immune system. Both innate and acquired immunity are compromised. The of pharmacotherapy is increasingly applied to enhance percentage success in maintaining alcoholic patients remission. Disulfiram, naltrexone gamma hydroxybutiric acid drugs used for this purpose Italian Addiction Services. In study we analyze effect dependence responses alcoholics. Six groups were studied. Group A included 10 who still using alcohol. B consisted...
Substance P (SP) is a tachykinin released from both the central and peripheral endings of primary afferent neurons functions as neurotransmitter. As transmitter signaling pain, substance involved in nociception an extremely potent vasodilator. We found several studies about this neuropeptide especially relation to parodontology few orthodontic reviews. This because past importance dental element undergoing periodontal inflammation was observed. The aims present pilot study investigate...
The use of gold nanoparticles (GNPs) as drug delivery system represents a promising issue for diseases without effective pharmacological treatment due to insufficient local accumulation and excessive systemic toxicity. Bronchiolitis obliterans syndrome (BOS) about 70% cases chronic lung allograft dysfunction, the main challenge long-term transplantation. It is believed that repeated insults epithelial bronchiolar cells inflammatory response creates milieu favors epithelial-mesenchymal...
In this paper we describe new actions of nimesulide and paracetamol in cultured peripheral neurons isolated from rat dorsal root ganglia (DRG). Both drugs were able to decrease a dose-dependent fashion the number DRG showing translocation protein kinase C epsilon (PKCɛ) caused by exposure 1 μM bradykinin or 100 nM thrombin. addition, level substance P (SP) released preprotachykinin mRNA expression measured basal conditions after 70 minutes 36 hours stimulation with nerve growth factor (NGF)...
Several nimesulide preparations (i.e., tablet form, gels) have been marketed, but no parenteral solution has achieved the market because of their low wettability and unsatisfactory chemical−physical properties required for use. In this paper we describe synthesis prodrug 1 its anti-inflammatory antihyperalgesic properties. Pharmacological studies, carried out to evaluate in vivo analgesic activities compound nimesulide, showed that sodium sulfamate is an effective can be administered by...
Intense, long exercise can increase oxidative stress, leading to higher levels of inflammatory mediators and muscle damage. At the same time, fatigue has been suggested as one factors giving rise delayed-onset soreness (DOMS). The aim this study was investigate efficacy a specific electrical stimulation (ES) treatment (without elicited muscular contraction) on two different scenarios: in laboratory eleven healthy volunteers (56.45 ± 4.87 years) after upper limbs eccentric (Study 1) field...