A5088354570- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Renal Transplantation Outcomes and Treatments
- Occupational and environmental lung diseases
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Blood Coagulation and Thrombosis Mechanisms
- Lung Cancer Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Airway Management and Intubation Techniques
- COVID-19 and healthcare impacts
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Polyomavirus and related diseases
University of Pavia
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Policlinico San Matteo Fondazione
2014-2024
Columbia University Irving Medical Center
2018-2020
KU Leuven
2015-2020
Columbia University
2018
University Hospital Foundation
2017
University of Turin
2016
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2015
Policlinico S.Orsola-Malpighi
2013
Aims: Chronic lung allograft dysfunction represents the main cause of death after transplantation, and so far there is no effective therapy. Mesenchymal cells (MCs) are primarily responsible for fibrous obliteration small airways typical chronic dysfunction. Here, we engineered gold nanoparticles containing a drug in hydrophobic section to inhibit MCs, exposing on outer hydrophilic surface monoclonal antibody targeting MC-specific marker (half-chain with everolimus). Materials & methods:...
Abstract Pulmonary alveolar proteinosis (PAP) is a term defining an ultra-rare group of disorders characterised by perturbation in surfactant homeostasis, resulting its accumulation within airspaces and impaired gas transfer. In this report we provide data from cohort PAP patients (n = 81) followed for more than two decades at the San Matteo University Hospital Pavia, Italy. agreement with other large series individuals, 90% study subjects were affected autoimmune/idiopathic PAP, while...
Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after transplantation, but there are no large studies.13 transplant centres in 10 European countries created cohort of 5707 patients. For each patient, we quantified residential particulate matter aerodynamic diameter ≤10 µm (PM10) by land use regression models, the exposure quantifying total...
The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention the literature. aim of present study was to evaluate role cardiac involvement respiratory failure a cohort hospitalized an academic hospital Lombardy, one most affected Italian (and worldwide) regions by epidemic. included 405 consecutive with confirmed admitted medical ward from February 25th March 31st, 2020. Follow-up surviving ended either at discharge or July 30th, Myocardial defined...
The role of CD4+CD25highCD127− T-reg cells in solid-organ Transplant (Tx) acceptance has been extensively studied. In previous studies on kidney and liver recipients, peripheral cell counts were associated to graft survival, while lung Tx, there is limited evidence for similar findings. This study aims analyze long term kinetics T-reg-cells a cohort recipients tests its association several clinical variables. From jan 2009 dec 2014, 137 Tx submitted an immunological follow up (median: 105.9...
Abstract Objectives Alpha-1-antitrypsin deficiency is a genetic disorder caused by mutations in the SERPINA1 gene encoding alpha-1-antitrypsin (AAT), major serine protease inhibitor plasma. Reduced AAT levels are associated with elevated risk of developing emphysema mainly due to uncontrolled activity neutrophil elastase lungs. The prevalent Z-AAT mutant and many rare pathogenic variants also predispose liver disease their accumulation as polymeric chains hepatocytes. Part these polymers...
Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of molecular steps responsible for transformation remain unclear; however, several growth factor signaling cascades are known be altered during MPM onset and progression. Transducers these pathways, such as PIK3CA-mTOR-AKT, MAPK, ezrin/radixin/moesin (ERM) could therefore exploited possible targets pharmacological...
This report describes the application of NMR spectroscopy to profiling metabolites in bronchoalveolar lavage fluid (BALf) lung transplant recipients without bronchiolitis obliterans syndrome (BOS) (stable, S, n = 10), and with BOS at different degrees severity (BOS 0p, 10; I, 10). Through fine-tuning a number parameters concerning both sample preparation/processing variations spectra acquisition modes, an efficient reproducible protocol was designed for screening pulmonary that should...
Chronic lung allograft dysfunction (CLAD) and interstitial disease associated with collagen tissue diseases (CTD-ILD) are two end-stage disorders in which different chronic triggers induce activation of myo-/fibroblasts (LFs). Everolimus, an mTOR inhibitor, can be adopted as a potential strategy for CLAD CTD-ILD, however it exerts important side effects. This study aims to exploit nanomedicine reduce everolimus effects encapsulating inside liposomes targeted against LFs, expressing high rate...
Sarcoidosis is a multisystem disease, which diagnosed on compatible clinical presentation, non-necrotizing granulomatous inflammation in one or more tissue samples, and exclusion of alternative causes disease. Considering its heterogeneity, numerous aspects the disease remain to be elucidated. In this context, identification integration biomarkers may hold significance practice, aiding appropriate selection patients for targeted trials. This work aims discuss analyze how validated are...
Alpha-1 antitrypsin deficiency (AATD) is an underdiagnosed disorder associated with mutations in the SERPINA1 gene encoding alpha-1 (AAT). Severe AATD can manifest as pulmonary emphysema and progressive liver disease. Besides most common pathogenic variants S (E264V) Z (E342K), many rarer genetic of AAT have been found patients general population. Here we report a panel new variants, including 4 null 16 missense alleles, identified among cohort individuals suspected whose phenotypic...
Abstract Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, magnitude of this association still needs be defined. Furthermore, clinical predictors thrombogenesis, and relationship with inflammatory status are currently unknown. On basis, we conducted a retrospective, observational study on 259 consecutive admitted academic tertiary referral hospital in Northern Italy between March 19th April...
PAP is an ultra-rare respiratory syndrome characterized by the accumulation of surfactant within alveoli. Whole lung lavage (WLL) current standard care PAP, however it not a standardized procedure and total amount fluid used to wash each still debated. Considering ICU hospitalization associated risks, "mini-WLL" with anticipated manual clapping reduced infusion volume has been proposed in our center. The aim study retrospectively analyze efficacy mini-WLL compared WLL at Pavia center.13...
The use of gold nanoparticles (GNPs) as drug delivery system represents a promising issue for diseases without effective pharmacological treatment due to insufficient local accumulation and excessive systemic toxicity. Bronchiolitis obliterans syndrome (BOS) about 70% cases chronic lung allograft dysfunction, the main challenge long-term transplantation. It is believed that repeated insults epithelial bronchiolar cells inflammatory response creates milieu favors epithelial-mesenchymal...