A5025869012- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Probiotics and Fermented Foods
- Antimicrobial Peptides and Activities
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Oral microbiology and periodontitis research
- Silk-based biomaterials and applications
- biodegradable polymer synthesis and properties
- Neuroblastoma Research and Treatments
- Gut microbiota and health
- Urinary Tract Infections Management
- Diabetes Treatment and Management
- Advanced Sensor and Energy Harvesting Materials
- Diabetes Management and Research
- Bone health and osteoporosis research
- Laser Applications in Dentistry and Medicine
- Nail Diseases and Treatments
- Regulation of Appetite and Obesity
- COVID-19 Clinical Research Studies
- Nanocomposite Films for Food Packaging
- Cancer, Hypoxia, and Metabolism
- Adrenal Hormones and Disorders
- Dermatologic Treatments and Research
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018-2025
University of Pavia
2022-2024
University of Campania "Luigi Vanvitelli"
2013-2024
National Interuniversity Consortium of Materials Science and Technology
2018-2024
Agostino Gemelli University Polyclinic
2024
Policlinico San Matteo Fondazione
2021-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
Ospedale Garibaldi
2018-2022
Presidio Ospedaliero
2022
Corvid Technologies (United States)
2021
Abstract Context: Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are conditions at high risk for the development of hypopituitarism. Objective: The objective study was to clarify whether pituitary deficiencies normal function recorded 3 months would improve or worsen 12 after injury. Design Patients: Pituitary tested in patients who had TBI (n = 70) SAH 32). Results: In TBI, 3-month evaluation shown hypopituitarism (H) 32.8%. Panhypopituitarism (PH), multiple (MH), isolated...
Acquired hypopituitarism in adults is obviously suspected patients with primary hypothalamic-pituitary diseases, particularly after neurosurgery and/or radiotherapy. That brain injuries (BI) can cause commonly stated and has been recently emphasized but the management of BI does not routinely include neuroendocrine evaluations.To clarify occurrence traumatic injury (TBI) or subarachnoid haemorrhage (SAH) 3 months BI.The conscious [TBI, n = 100, 31 women, 69 men; age 37.1 +/- 1.8 years; body...
Traumatic brain injury (TBI) may be associated with impairment of pituitary hormone secretion, which contribute to long-term physical, cognitive, and psychological disability. We studied the occurrence risk factors dysfunction, including growth deficiency (GHD) in 50 patients (mean age 37.6 ± 2.4 years; 40 males, 20–60 10 females, 23–87 years) TBI over 5 years. Cranial or facial fractures were documented 12 patients, neurosurgery was performed 14. According Glasgow Coma Scale (GCS), 16 had...
This cross-sectional study shows that high numbers of postmenopausal women with acromegaly develop vertebral fractures in relation to the activity disease. In patients active acromegaly, occur even presence normal BMD, whereas controlled are always accompanied by a pathological BMD.We studied frequency radiological cohort or acromegaly.Thirty-six acromegalic (15 and 21 disease) were evaluated for bone metabolism (serum 25-hydroxyvitamin D, PTH, bone-specific alkaline phosphatase [BSALP],...
Data on osteoporotic fractures in acromegaly are limited. An increased prevalence of radiological vertebral was already observed postmenopausal women with active acromegaly. It is unknown whether this observation may reflect a more general risk acromegaly.This cross-sectional study.The study conducted at referral centers.Subjects included 40 males (25 patients controlled disease and 15 disease) 31 control males, age gonadal status comparable the patients.Evaluation (quantitative morphometric...
Chitin and lignin, by-products of fishery plant biomass, can be converted to innovative high value bio- eco-compatible materials. On the nanoscale, antibacterial, anti-inflammatory, cicatrizing anti-aging activity is obtained by controlling their crystalline structure purity. Moreover, electropositive chitin nanofibrlis (CN) combined with electronegative nanolignin (NL) leading microcapsule-like systems suitable for entrapping both hydrophilic lipophilic molecules. The aim this study was...
The intestinal mucosa is composed of a monolayer epithelial cells, which highly polarized and firmly united to each other thanks the presence proteins complexes, called Tight junctions (TJs). Alteration mucus layer TJs causes an increase in permeability, can lead microbial translocation systemic disorders. Candida albicans , addition its role commensal, opportunistic pathogen responsible for disseminated candidiasis, especially immunocompromised subjects where dysbiosis leads damage mucosal...
In this study, P-doped TiO2 photocatalysts with different molar percentages (in the range 0.071-1.25 mol %) of non-metallic element were prepared and their photocatalytic activity under visible light irradiation was tested. All achieved samples characterized by XRD, Raman, UV-Vis DRS SEM-EDX techniques. XRD Raman analysis showed that all doped in anatase phase evidenced P ions successfully incorporated into crystal lattice, affecting also crystallinity degree photocatalysts. Noticeably,...
Lactococcus lactis is a lactic acid bacterium (LAB), generally recognized as safe, and has been widely used in the food industry, especially fermented dairy products. Numerous studies have evaluated technological probiotic properties of lactococci; however, few reported characteristics L. strains isolated from In this work, potential, including survival simulated gastric juice, tolerance to bile salts, hydrophobicity, auto- co-aggregation, was natural whey starter cultures. The results...
Abstract This cross-sectional study shows that a high number of untreated adult patients with GHD develop radiological vertebral deformities. Patients undergoing GH replacement treatment showed significantly lower prevalence deformities versus treated in the presence similar BMD, as assessed by DXA. Introduction: In this study, we investigated whether and degree spinal adults growth hormone deficiency (GHD) were related to age patients, bone turnover, recombinant human (rhGH) therapy....
Ki-67 is a marker of proliferation activity associated with invasiveness and prognosis in human tumors.The aim the study was to evaluate index prognostic relevance group acromegalic patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma.We selected 68 consecutive referred our hospital during 5-yr period. The determined by immunohistochemistry on tissue samples obtained from each adenoma after surgery. Those were not completely cured began medical therapy...
Polyhydroxyalkanoates (PHAs) are a family of bio-based polyesters that have found different biomedical applications. Chitin and lignin, byproducts fishery plant biomass, show antimicrobial anti-inflammatory activity on the nanoscale. Due to their polarities, chitin nanofibril (CN) nanolignin (NL) can be assembled into micro-complexes, which loaded with bioactive factors, such as glycyrrhetinic acid (GA) CN-NL/GA (CLA) complexes, used decorate polymer surfaces. This study aims develop...
Background: The integrity of the intestinal barrier is fundamental to gut health and homeostasis; its damage can increase permeability, with translocation bacteria and/or endotoxins from gut, onset various diseases. Lactobacillus spp. one most common probiotics normally found in fermented foods dairy products known for anti-inflammatory immunomodulatory properties ability protect enhance functions. aim this work was evaluate different strains improve vitro barrier, exert activity prevent...
Obesity is characterized by increased leptin levels and insulin resistance, whereas blunted GH secretion paired with normal, low, or high plasma IGF-I levels. To investigate body composition in human obesity the interactions among GH-IGF-I axis, leptin, resistance [measured homeostasis model assessment (HOMA) score], we studied 15 obese females, aged 23-54 yr (mean age, 42.7 +/- 2.6), a mass index (BMI) of 44.02 1.45 kg/m(2), who underwent treatment biliopancreatic diversion (BPD), before...
Ten percent of patients with prolactinoma fail to respond normalization prolactin (PRL) and tumor shrinkage under dopamine agonist (DA) therapy. The resistance treatment is linked a loss receptor 2 (D2DR). Prolactinomas express somatostatin (SST) subtypes, SSTR1, 2, 5. aim this study was determine whether different SST compounds could overcome the DA in prolactinomas.The efficacy SSTR2, SSTR5 ligands; universal ligand, SOM230; chimeric SST-DA compound, BIM-23A760, compared cabergoline...
The intestinal microbiota is a major factor in human health and disease. This microbial community includes autochthonous (permanent inhabitants) allochthonous (transient microorganisms that contribute to maintaining the integrity of wall, modulating responses pathogenic noxae representing key maturation immune system. If this healthy disrupted by antibiotics, chemotherapy, or change diet, colonization bacteria viruses may occur, leading To manage substantial exposure, epithelial surfaces...
Biodegradable polymers are promising materials for films and sheets used in many widely diffused applications like packaging, personal care products sanitary products, where the synergy of high biocompatibility reduced environmental impact can be particularly significant. Plasticized poly(lactic acid) (PLA)/poly(butylene succinate) (PBS) blend-based films, showing cytocompatibility improved flexibility than pure PLA, were prepared by laboratory extrusion their processability was controlled...
Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion biofilm formation ameliorate colonization of urinary crystalline biofilms on abiotic surface catheters. Since, date, role P. in etiopathogenesis different types not well established, this study we sought characterize two clinically isolated strains (PM1 PM2) with distinctive phenotypes...
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function 100 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit March 2020. retrospectively assessed tests, taking into account demographic characteristics and outcome. A patient was considered as having injury when alanine aminotransferase (ALT) > 50 mU/ml, gamma-glutamyl...
Due to the morbidity and lethality of pulmonary diseases, new biomaterials scaffolds are needed support regeneration lung tissues, while ideally providing protective effects against inflammation microbial aggression. In this study, we investigated potential nanocomposites poly(vinylidene fluoride-co-trifluoroethylene) [P(VDF-TrFE)] incorporating zinc oxide (ZnO), in form electrospun fiber meshes for tissue engineering. We focused on their anti-inflammatory, antimicrobial, mechanoelectrical...
Nanobiocomposites suitable for preparing skin compatible films by flat die extrusion were prepared using plasticized poly(lactic acid) (PLA), poly(butylene succinate-co-adipate) (PBSA), and Chitin nanofibrils as functional filler. (CNs) dispersed in the blends thanks to preparation of pre-nanocomposites containing poly(ethylene glycol). Thanks use a melt strength enhancer (Plastistrength) calcium carbonate, processability thermal properties bionanocomposites CNs could be tuned wide range....