A5087605657- Ultrasound in Clinical Applications
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Radiology practices and education
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 diagnosis using AI
- Analytical Chemistry and Sensors
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Porphyrin Metabolism and Disorders
- Epigenetics and DNA Methylation
- Climate Change and Health Impacts
- Methemoglobinemia and Tumor Lysis Syndrome
- Genomics and Rare Diseases
- Meningioma and schwannoma management
- dental development and anomalies
- Planarian Biology and Electrostimulation
- Occupational Therapy Practice and Research
- Neurofibromatosis and Schwannoma Cases
- Genetic Neurodegenerative Diseases
- Dielectric materials and actuators
- Advanced Sensor and Energy Harvesting Materials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Heme Oxygenase-1 and Carbon Monoxide
Meyer Children's Hospital
2024
University of Pavia
2020-2023
Meyer Children's Hospital
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2001-2022
Policlinico San Matteo Fondazione
2018-2022
Corvid Technologies (United States)
2021
University of Rome Tor Vergata
2020
University of Florence
2007-2020
Piaggio (Italy)
2016
University of Pisa
2016
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection can generate severe pneumonia associated with high mortality. A bedside lung ultrasound (LUS) examination has been shown to have a potential role in this setting. The purpose of study was evaluate the prognostic value new LUS protocol (evaluation 14 anatomic landmarks, graded scores 0–3) patients SARS‐CoV‐2 and association patterns clinical or laboratory findings. Methods cohort 52 consecutive...
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function 100 consecutive patients (median age 70 years, range 25-97; 79 males) who were admitted to our internal medicine unit March 2020. retrospectively assessed tests, taking into account demographic characteristics and outcome. A patient was considered as having injury when alanine aminotransferase (ALT) > 50 mU/ml, gamma-glutamyl...
Abstract Background COVID‐19 outbreak prompted health centres to reorganize their clinical and surgical activity. In this paper, we show how medical genetics department's activity, in our tertiary pediatric hospital, has changed due pandemic. Methods We stratified all scheduled visits, from March 9th through April 30th, assessed case‐by‐case which genetic consultations should be maintained as face‐to‐face visit, or postponed/switched telemedicine. Results Out of 288 appointments, 60 were...
Abstract Context Silver–Russell Syndrome (SRS) is a growth retardation disorder characterized by pre- and postnatal failure, relative macrocephaly at birth, prominent forehead, body asymmetry, feeding difficulties. The main molecular mechanisms are imprinting alterations multiple loci, though small number of pathogenic variants have been reported in the SRS genes IGF2-PLAG1-HMGA2 CDKN1C. However, around 40% clinically suspected cases do not achieve diagnosis, highlighting necessity to...
Hydroxychloroquine and phlebotomy were compared in the treatment of porphyria cutanea tarda (PCT). Thirty patients received hydroxychloroquine (200 mg twice weekly) for 1 year thirty‐one underwent twice‐monthly phlebotomies 400 ml whole blood each, also year. Clinical signs disease improved equally both groups. At end year, urinary porphyrin excretion had significantly twenty‐two out thirty hydroxychloroquine‐ treated subjects, but only eight who phlebotomy. Liver histology showed...
This study describes an actuated bioreactor which mimics the pulsatile contractile motion of intestinal barrier using electro-responsive elastomers as smart materials that undergo deformation upon electrical stimulation. The device consists annular dielectric elastomer actuator working a radial artificial muscle able to rhythmically contract and relax central cell culture well. maintained up 4 h actuation at frequency 0.15 Hz strain 8%-10%, those cyclic contraction relaxation small...
Abstract Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, magnitude of this association still needs be defined. Furthermore, clinical predictors thrombogenesis, and relationship with inflammatory status are currently unknown. On basis, we conducted a retrospective, observational study on 259 consecutive admitted academic tertiary referral hospital in Northern Italy between March 19th April...
The study of nanomaterial translocation across epithelial barriers is often hindered by the low permeability transwell membranes to nanoparticles. To address this issue ultra-thin poly(L-lactic acid) nanofilms with zero tortuosity micropores were developed for use in nanoparticle passage tests. In we demonstrate that microporous polymeric allow a significantly higher silver nanoparticles comparison commercial normally used inserts. A reliable procedure collecting free-standing which enables...
DM1 is an autosomal dominant multisystemic disease caused by unstable CTG repeat expansion in the 3'-untranslated region (UTR) of DMPK gene. The complex variant expanded alleles containing CAG, CCG, CTC and/or GGC interruptions repetition sequences have been reported 3-8% patients. To date, very few information available about frequency and clinical consequences pre-mutated allele. In this study, we describe a three-generation Italian family showing segregation interrupted allele within...
We report the case of a 16-year-old girl presenting with spinal clear-cell multiple meningiomas (CCMs). In view this presentation, we sequenced bioinformatic panel genes associated susceptibility to meningioma, identifying germline heterozygous variant in SMARCE1. Somatic DNA investigations CCM demonstrated deletion wild-type allele (loss heterozygosity, LOH), supporting causative role variant. Family segregation study detected SMARCE1 asymptomatic father and sister who, nevertheless,...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Abdominal ultrasound (US) by far the most widely used first-level exam for diagnosis HCC. We aimed to assess whether different patterns were related tumor prognosis. retrospectively reviewed all patients with new HCC (single nodule) and undergoing radiofrequency thermal ablation (RFTA) at our clinic between January 2009 December 2021. Patients classified according four patterns: 1A, single capsulated nodule; 1B, well...
Atypical physiological symptoms can be developed in healthy people under critically ill conditions. pH, pO<sub>2</sub> and pCO<sub>2</sub> are informative indicators of the conditions a living system valuable determining physiologic status patients. The continuous monitoring these small molecules into interstitial fluid (ISF) is promising approach to reduce diagnostic blood loss painful stress associated with sampling. Microdialysis followed for extraction sample from subcutaneous adipose...
In recent years, lung ultrasound (LUS) has spread to emergency departments and clinical practise gaining great support, especially in time of pandemic, but only a few studies have been done on children. The aim the present study is compare diagnostic accuracy LUS (using Soldati score) that chest X-ray (CXR) CAP COVID-19 pneumonia paediatric patients. Secondary objective examine association between score disease severity. Finally, we describe local epidemiology during period era by comparing...
Background: Pressure Ulcers (PU) in hospitals are a major problem, including pediatric settings.Knowledge of the epidemiology and risk factors PUs is important, as use specific tool for assessment PU risk, which would allow identification subjects at risk.No Pediatric Risk Assessment Scales currently validated Italian.The goals this study were: to perform linguistic cultural validation Glamorgan Ulcer Scale (GS) Italian, estimate its predictive performance frequency hospitalized children....
A pH sensor based on optical fibres was developed. The analysed sample is the interstitial fluid drawn from adipose tissue by means of a microdialysis catheter. sensing layer constituted indicator, phenol red, directly immobilised onto internal wall glass capillary. interrogation capillary performed an optoelectronic unit, developed in our laboratory, which makes use light emitting diode at 590 nm as source and photodiode detector. suitable animal model in-vivo tests pigs were carried out.
McKittrick-Wheelock syndrome is a rare condition characterized by secretory diarrhea due to villous adenoma of the colon, acute renal failure, dehydration, electrolyte and acid-base disorders. Diagnosis requires high suspicion especially when presentation unusual. Although potentially fatal for its complications, if promptly diagnosed treated it completely reversible. We present case 67-year-old man who presented with syncope diarrhea. On admission arterial blood gas test showed complex...