A5100678540- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Nanoparticles: synthesis and applications
- Cardiovascular Function and Risk Factors
- Computational Drug Discovery Methods
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Pregnancy and preeclampsia studies
- Polymer Surface Interaction Studies
- Cardiac Imaging and Diagnostics
- 3D Printing in Biomedical Research
- Pulmonary Hypertension Research and Treatments
- Renal and related cancers
- Acute Myocardial Infarction Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
Instituto Dante Pazzanese de Cardiologia
2023
Fluidda (United States)
2023
University of Pisa
2016-2021
Piaggio (Italy)
2016-2021
Fondazione Stella Maris
2020
University of Genoa
2020
IMT School for Advanced Studies Lucca
2016
The study of nanomaterial translocation across epithelial barriers is often hindered by the low permeability transwell membranes to nanoparticles. To address this issue ultra-thin poly(L-lactic acid) nanofilms with zero tortuosity micropores were developed for use in nanoparticle passage tests. In we demonstrate that microporous polymeric allow a significantly higher silver nanoparticles comparison commercial normally used inserts. A reliable procedure collecting free-standing which enables...
Abstract To determine whether quantitative computed tomography (qCT)‐derived metrics of pulmonary vascular volume distribution could distinguish chronic obstructive disease (COPD) subjects with associated hypertension (PH) from those without and to characterize associations these measurements clinical physiological characteristics outcomes. We collected retrospective CT, hemodynamic, clinical, outcomes data COPD right‐heart catheterization‐confirmed PH (PH‐COPD) control but PH. measured the...
Dose assessment is essential for understanding the mechanisms triggering nanomaterial toxicity in vitro and meaningful translations to vivo. We propose a novel computational approach improving accuracy of biological dose-response characterization, demonstrating its robustness insoluble Engineered Nanomaterials (ENMs).
Nano and micro particles are widely used in industrial, household medicinal applications. To understand the interaction between epithelial cells, we developed a dynamic model of alveolar interface. This system, named DALI (Dynamic Model for ALveolar Interface), is modular bioreactor composed two chambers divided by porous membrane where lung cells seeded. The support barrier that separates compartments alveolus: air blood side. system integrates following elements: i) Air/Liquid interface,...
Abstract Multidrug resistance is still an obstacle for chemotherapeutic treatments. One of the proteins involved in this phenomenon P-glycoprotein, P-gp, which known to be responsible efflux therapeutic substances from cell cytoplasm. To date, identification a drug that can efficiently inhibit P-gp activity remains challenge, nevertheless some studies have identified natural compounds suitable purpose. Amongst them, curcumin has shown inhibitory effect on protein vitro using Caco-2 cells....
Abstract Introduction In patients with ST- segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) should be conducted within 12 hours of symptom onset regardless viability status. The potential benefits attributable to late reperfusion in STEMI fall under the "open artery hypothesis" where stunned peri-infarction zone after revascularization would restore blood supply and contractility.Purpose: To estimate differences on LV ejection fraction (LVEF) indexed...
Abstract Multidrug resistance is still an obstacle for chemotherapeutic treatments. One of the proteins involved in this phenomenon P-glycoprotein, P-gp, which known to be responsible efflux therapeutic substances from cell cytoplasm. To date, identification a drug that can efficiently inhibit P-gp activity remains challenge, nevertheless some studies have identified natural compounds suitable purpose. Amongst them, curcumin has shown inhibitory effect on protein vitro using Caco-2 cells.To...
Dose assessment is essential for understanding the mechanisms triggering nanomaterial toxicity in vitro and meaningful translations to vivo. We propose a novel computational approach improving accuracy of biological dose-response characterization, demonstrating its robustness insoluble Engineered Nanomaterials (ENMs).