A5073145368- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Cancer Treatment and Pharmacology
- Vascular Malformations Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Radiation Therapy and Dosimetry
- Complementary and Alternative Medicine Studies
- Chromatin Remodeling and Cancer
- Boron Compounds in Chemistry
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Childhood Cancer Survivors' Quality of Life
- Cancer-related Molecular Pathways
- Adenosine and Purinergic Signaling
- Fetal and Pediatric Neurological Disorders
- Multiple and Secondary Primary Cancers
- Cancer-related cognitive impairment studies
- Natural Compounds in Disease Treatment
- Breast Lesions and Carcinomas
- Nanoplatforms for cancer theranostics
Meyer Children's Hospital
2024
Meyer Children's Hospital
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
University of Florence
2013-2021
IMT School for Advanced Studies Lucca
2015-2016
Santa Maria Nuova Hospital
2015
University of Havana
2015
The fields of application topically administered platelet derivatives are numerous and increasing. use this blood component is based on the fact that it contains growth factors proteins clotting system. Studies carried out so far have been aimed at identifying these substances, assaying their content in various types concentrate used, determining vivo vitro mechanisms action, trying to standardise production methods. However, much still remains be discovered, not only about factors, but also...
Abstract INTRODUCTION Chemotherapy remains the cornerstone in case of incompletely resected pedatric Low Grade Glioma (pLGGs) and for recurrent tumors unfavorable locations. Based on previous cisplatin etoposide regimen (INT Milan strategy), we tried to reduce toxicity achieve a similar tumor control using modified composed CBCDA-etoposide. METHODS From August 2012 December 2023 treated 79 pLGGS (45 F (57%), 34 M (43%)) with carboplatin (400 mg/m2 day 1) (100 mg/2 1-3) at 4-6 weeks interval...
Malignant meningioma has a bad prognosis. Surgery and radiotherapy are the most effective therapeutic options, without an established role for chemotherapy. We report case of 2-year-old male child with diagnosis postoperative relapse malignant meningioma. Considering rapid progression, young age lack alternatives, patient underwent multidisciplinary anticancer treatment protocol made soft tissue sarcomas (EpSSG NRSSTS 2005 protocol), positive outcome. This represents successful management...
Abstract BACKGROUND Malignant brain tumors, such as Glioblastoma (GBM), are a major challenge in oncology with dismal prognosis. This can be part explained by the inability to deliver more effective drugs, Doxorubicin (DOX), into because of resistance mechanisms. tumors GBM also show an elevated glycolytic rate through glucose transporters and GLUT1 is reported main mediator BBB uptake. For these reasons, we have developed innovative approach able increase drug efficiency selectivity,...
Abstract BACKGROUND The high risk medulloblastoma remains a leading cause of cancer-related death in children. METHODS A total 18 patients have been enrolled from February 2018 to May 2022.The median age was 7,5 years (range; 12 males and 6 female). protocol predicted the first phase induction with 4 cycles chemotherapy. After favorable histology without evidence disease were proton therapy (with concomitant vinorelbine biweekly). maintenance Lomustine repeated every 9 weeks 3 for overall...
Abstract BACKGROUND Optic pathway gliomas (OPG) are low-grade tumors (LGG) that affect the precortical visual pathway, representing 3-5% of pediatric brain tumors, more often diagnosed before age 5 years. Although histologically benign, due to their location and thus unresectability, they carry considerable morbidity, bringing progressive loss. In up 20% cases detected in patients with neurofibromatosis type 1 (NF1). Consolidated chemotherapy regimen or without biopsy debulking, if feasible,...
Abstract BACKGROUND Gemcitabine plus oxaliplatin chemotherapy (GemOx) represents a possible option in advanced hepatocholangiocarcinoma and pancreatic cancer of adulthood. Considering the pediatric population, it was evaluated recurrent solid tumors children with non-Hodgkin lymphoma unable to tolerate intensive therapy. We report our single-center experience on applicability GemOx infant type brain tumors. MATERIAL AND METHODS At Meyer Children’s Hospital IRCCS Florence (Italy), from May...
We report the case of a 16-year-old girl presenting with spinal clear-cell multiple meningiomas (CCMs). In view this presentation, we sequenced bioinformatic panel genes associated susceptibility to meningioma, identifying germline heterozygous variant in SMARCE1. Somatic DNA investigations CCM demonstrated deletion wild-type allele (loss heterozygosity, LOH), supporting causative role variant. Family segregation study detected SMARCE1 asymptomatic father and sister who, nevertheless,...
Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, most cases not previously irradiated. The efficacy bevacizumab also described radiation necrosis. Considering the possible overlapping treatment effect disease progression difficulty differentiating, we report on use BEVIRI a case relapsing...
Abstract BACKGROUND The diagnosis of a child’s brain tumor is terrible situation for every member the family. Numerous are case separations and divorces in Italy after cancer. In particular, it happens with parents children affected tumor, being most frequent solid first cause death. crisis related to discovery consists four phases: shock, reaction, processing re-orientation. It can happen that diagnosis, experienced as traumatic experience, unite family members well separate them. If there...
This case describes the strong utility of optical coherence tomography in multidisciplinary management a complex type 2 neurofibromatosis.