A5023971080- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune and Inflammatory Disorders Research
- Ophthalmology and Visual Impairment Studies
- Ocular Disorders and Treatments
- Histiocytic Disorders and Treatments
- Retinopathy of Prematurity Studies
- Research on Leishmaniasis Studies
- Vascular Malformations and Hemangiomas
- Systemic Lupus Erythematosus Research
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Autoimmune and Inflammatory Disorders
- Neurofibromatosis and Schwannoma Cases
- melanin and skin pigmentation
- Herpesvirus Infections and Treatments
- Optical Coherence Tomography Applications
- Ophthalmology and Eye Disorders
Meyer Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2024
University of Florence
2011-2023
Azienda Ospedaliero-Universitaria Careggi
2022
Ghent University Hospital
2022
Azienda Sanitaria Unità Locale di Reggio Emilia
2022
Children's Hospital of Philadelphia
2022
Weatherford College
2021
Sapienza University of Rome
2021
Boston Children's Hospital
2001-2017
To compare the efficacy and safety of adalimumab versus infliximab in an open-label prospective, comparative, multicenter cohort study childhood noninfectious chronic uveitis.Thirty-three patients (22 females, 11 males, median age 9.17 years) with refractory, vision-threatening, active uveitis were enrolled, received for at least 1 year (5 mg/kg weeks 0, 2, 6, then every 6-8 weeks) or (24 mg/m2 2 weeks). The primary outcome was to assess, once remission achieved, time a first relapse. Time...
To report on the clinical response to canakinumab in a patient with sporadic nucleotide-binding oligomerization domain-containing protein 2 (NOD-2)-associated pediatric granulomatous arthritis (Blau syndrome) and severe resistant panuveitis, describe gene expression profile changes throughout such treatment.A 4-year-old boy was diagnosed as having Blau syndrome basis of typical features, histologic evidence noncaseating granulomas, NOD2 mutation. Ocular involvement initially controlled by...
Nonetheless biologic modifier therapies are available treatment strategies for sight-threatening uveitis in children, the lack of evidence from head-to-head randomized controlled studies limits our understanding timing therapy when to commence therapy, which agent choose and how long continue treatment, and, case failure, if switching another anti-TNF-α strategy might be eventually an option. Our aim was compare efficacy Adalimumab used as first anti-TNFα versus after failure a previous...
Purpose To evaluate the efficacy and safety of using sodium hyaluronate 0.1% carboxymethylcellulose 0.5% artificial tears for ocular discomfort tear-film stability in eyes after cataract surgery. Setting Twenty ophthalmic centers Italy. Design Prospective randomized case series. Methods This study enrolled patients scheduled unilateral After surgery, received a topical steroid–antibiotic (study group) or alone (control were assessed postoperatively at 1 5 weeks. Outcome measures tear breakup...
Vernal keratoconjunctivitis (VKC) is a chronic and potentially sight-threatening disease. Topical corticosteroids (Cs) seem to be the only effective treatment for this condition, although severe side effects may occur owing their prolonged use. More recently, cyclosporine (Cyc) eye drops have been reported as valid alternative, but so far such has successfully experimented short time in small numbers of patients. The aim our study evaluate long term safety efficacy topical children suffering...
Abstract Background Vernal keratoconjunctivitis ( VKC ) is a chronic sight‐threatening ocular disease. Topical cyclosporine A (Cyc) has been widely administered as steroid‐sparing drug, although in about 7–10% of cases, it ineffective. The purpose this study was to evaluate the efficacy 0.1% topical tacrolimus (Tcr) patients with severe who failed respond 1% Cyc eyedrops. Methods Consecutive severe, Cyc‐resistant were enrolled double‐blind, comparative, crossover DBCO trial; all treated one...
Aims/Purpose: To compare the effectiveness of myopia control spectacle lenses with Highly Aspherical Lenslets (HAL) to Defocus Incorporated Multiple Segments (DIMS) in European children progressive after 12M & 24M lens usage. Methods: In this retrospective study, data from 146 myopic patients (73 treated DIMS vs. 73 HAL), aged 6‐17 years (mean age ±SD, 11.3±2.36) Spherical Equivalent Refraction (SER) between ‐0.50D ‐9.25D and no associated ocular pathology were included. equivalent...
Aims/Purpose: To compare the effectiveness of myopia control spectacle lenses with Highly Aspherical Lenslets (HAL) to Defocus Incorporated Multiple Segments (DIMS) in European children progressive after 12M & 24M lens usage. Methods: In this retrospective study, data from 146 myopic patients (73 treated DIMS vs. 73 HAL), aged 6‐17 years (mean age ±SD, 11.3±2.36) Spherical Equivalent Refraction (SER) between ‐0.50D ‐9.25D and no associated ocular pathology were included. equivalent...
Monocentric retrospective case series to describe clinical and molecular peculiarities in a of pediatric patients attempting possible genotype-phenotype correlation. We included 13 from 7 unrelated families (ages 1-18) with biallelic pathogenic likely variants RDH12 gene. For all our segregation analyses were performed their parents affected siblings. According cooperation, underwent complete ophtalmic examination imaging full field standard electroretinography (ffERG), spectral domain...
Objective. To describe efficacy and safety of infliximab in the treatment childhood chronic uveitis during a long-term follow-up.
Out of 105 renal transplant recipients 100 had skin lesions: 55% iatrogenic, 74% infectious, 12% precancerous or cancerous and 4% miscellaneous. Many these lesions were at least in part transient, steroid-related became less frequent as years progressed. The more infections the fungal ones, followed by viral bacterial with different patterns onset. All appeared late almost exclusively represented actinic keratoses; 2 evolved into squamous cell epitheliomata. patients died due to Kaposi's...
Purpose: Recent studies on adults have shown that short-term monocular deprivation boosts the deprived eye signal in binocular rivalry, reflecting homeostatic plasticity. Here we investigate whether plasticity is present also during occlusion therapy for moderate amblyopia. Methods: Binocular rivalry and visual acuity (using Snellen charts children) were measured 10 children (mean age 6.2 ± 1 years) with anisometropic amblyopia before beginning of treatment at four intervals (2 hours, 1, 2,...
A predominance of Th2 response has been suggested in vernal keratoconjunctivitis (VKC), and a high prevalence IgE-sensitized (IgE-S) patients reported (positive skin prick test or serum-specific-IgE). Palpebral bulbar VKC are considered to be expressions the same disease only occasional racial histopathological differences described between two forms. Tear levels eosinophil cationic proteins have correlated with severity ocular symptoms; however, there is no published study that demonstrates...
Objective. Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, foreign bodies. These factors induce worsening of signs symptoms VKC, whereas mechanical produces relief. The aim this study was to evaluate eyelash length large series VKC patients age- gender-matched healthy subjects. Methods. Upper measured 93 (mean age: 8.7...
Purpose To evaluate the correlation between degree of anisometropia with depth amblyopia and presence stereopsis. Methods A retrospective chart review 119 patients treated during 1995–2004 was carried out. All had undergone a full ophthalmological examination. Inclusion criteria were: >1 diopter (spherical and/or cylindrical), age at first examination 2 8 years, no previous optical correction, absence ocular neurological disorders, motility minimum follow-up years (mean 7.9 ± 4.3). Optical...
Objective. To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment. Methods. A retrospective, multicenter, cohort study. Results. Ninety-four children remission, receiving no treatments and with at least a 6-month followup, were enrolled. higher probability maintaining remission discontinuing treatment was shown idiopathic compared juvenile arthritis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months...