Irene Schiavetti
A5028131236- Multiple Sclerosis Research Studies
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Long-Term Effects of COVID-19
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Pediatric health and respiratory diseases
- Orthodontics and Dentofacial Orthopedics
- Ocular Infections and Treatments
- Eosinophilic Esophagitis
- Dental Implant Techniques and Outcomes
- Intraocular Surgery and Lenses
- Injury Epidemiology and Prevention
- Temporomandibular Joint Disorders
University of Genoa
2016-2025
Ospedale Policlinico San Martino
2016-2022
Nationwide Children's Hospital
2022
Istituto Giannina Gaslini
2022
Department of Medical Sciences
2014-2021
Azienda Ospedaliero-Universitaria Careggi
2017
Imperial College London
2017
Martin University
2017
Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta
2013
This study was undertaken to assess the impact of immunosuppressive and immunomodulatory therapies on severity coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (PwMS).We retrospectively collected data PwMS suspected or confirmed COVID-19. All patients had complete follow-up death recovery. Severe COVID-19 defined by a 3-level variable: mild not requiring hospitalization versus pneumonia intensive care unit (ICU) admission death. We evaluated baseline characteristics MS...
In patients with Multiple Sclerosis (pwMS) disease-modifying therapies (DMTs) affects immune response to antigens. Therefore, post-vaccination serological assessments are needed evaluate the effect of vaccine on SARS-CoV-2 antibody response.We designed a prospective multicenter cohort study enrolling pwMS who were scheduled for SARS-Cov-2 vaccination mRNA vaccines (BNT162b2, Pfizer/BioNTech,Inc or mRNA-1273, Moderna Tx,Inc). A blood collection before first dose and 4 weeks after second was...
Abstract We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, a pooled‐analysis two large cohorts from Italy and France. The association baseline characteristics was assessed by multivariate ordinal‐logistic models pooled fixed‐effect meta‐analysis. 1066 MS 721 France were included. In model, anti‐CD20 therapies significantly associated (OR = 2.05, 95%CI 1.39–3.02, p < 0.001) severity, whereas interferon indicated decreased risk 0.42, 0.18–0.99, 0.047). This confirms...
BackgroundIn this study we aimed to monitor the risk of breakthrough SARS-CoV-2 infection in patients with MS (pwMS) under different DMTs and identify correlates reduced protection.MethodsThis is a prospective Italian multicenter cohort study, long-term clinical follow-up CovaXiMS (Covid-19 vaccine Multiple Sclerosis) study. 1855 pwMS scheduled for mRNA vaccination were enrolled followed up mean time 10 months. The cumulative incidence Covid-19 cases was calculated before after December...
Purpose To evaluate the efficacy of a myopia control spectacle lens (DIMS) at slowing progression in population European children comparison with 0.01% atropine and combined DIMS atropine. Methods The study was non-randomised experimenter-masked prospective controlled observational individuals aged 6–18 years progressing but no ocular pathology. Participants were allocated, according to patient/parent choice, receive eyedrops, (Hoya ® MiyoSmart ) spectacles, atropine+DIMS or single vision...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
Background. Type-2 inflammation commonly marks asthma in childhood. Also, gut and lung dysbiosis is detectable patients with asthma. Strain-related probiotic supplementation may restore a physiological immune response, dampen airway inflammation, repair dysbiosis. Therefore, the probiotics pediatric management (PROPAM) study aimed at demonstrating that Ligilactobacillus salivarius LS01 (DSM 22775) Bifidobacterium breve B632 24706) mixture could reduce exacerbations children, followed primary...
Background: Patients with multiple sclerosis (pwMS) treated anti-CD20 or fingolimod showed a reduced humoral response to SARS-CoV-2 vaccines. Objective: In this study we aimed monitor the risk of breakthrough infection in pwMS on different disease-modifying therapies (DMTs). Methods: Data number vaccinated patients and were retrospectively collected 27 Italian MS centers. We estimated rate infections requiring hospitalization per DMT. Results: 19,641 included database. After median follow-up...
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
Background: Randomized clinical trials (RCTs) in progressive multiple sclerosis (MS) often revealed non-significant treatment effects on disability progression. Objectives: To investigate whether the failure to detect a significant benefit from may be motivated by delay effect, possibly related baseline characteristics. Methods: We re-analyzed data two RCTs testing interferon-beta and glatiramer-acetate versus placebo MS with no effect EDSS first designed time-dependent Cox model up time = t...
Background: Immunosuppressive and immunomodulatory therapies are a major issue during the current coronavirus disease 2019 (Covid-19) pandemic, in anticipation of possible next waves. Methods: In nationwide study we retrospectively collected data persons with Multiple Sclerosis (PwMS) suspected or confirmed Covid-19. We assessed association for MS Covid-19 by comparing their observed frequency one expected non-pandemic conditions (expressing Odds Ratios [OR]). evaluated baseline...
The CoronaVirus Disease 19 (COVID-19) pandemic is a threat of particular concern for people affected by chronic immune-mediated diseases, such as multiple sclerosis (MS), who are often treated with immunomodulatory and immunosuppressive drugs, which may increase the risk infections in general. At beginning COVID-19 pandemic, empirical guidelines on how to manage treatments including MS, were released. Subsequently, first clinical pictures data sets have been published, describing outcomes...
Neurofibromatosis type 1 (NF1) is a proteiform genetic condition caused by pathogenic variants in NF1 and characterized heterogeneous phenotypic presentation. Relevant genotype–phenotype correlations have recently emerged, but only few pertinent studies are available. We retrospectively reviewed clinical, instrumental, data from cohort of 583 individuals meeting at least diagnostic National Institutes Health (NIH) criterion for NF1. Of these, 365 subjects fulfilled ≥2 NIH criteria, including...
Influenza-like illness (ILI) patients co-detected with respiratory pathogens exhibit poorer health outcomes than those single infections. To address the paucity of knowledge concerning incidence concurrent pathogens, their relationships, and clinical differences between detected multiple we performed an in-depth characterization oropharyngeal samples primary care collected in Genoa (Northwest Italy), during winter seasons 2018/19-2019/20.The apriori algorithm was employed to evaluate viral,...
Aims/Purpose: To compare the effectiveness of myopia control spectacle lenses with Highly Aspherical Lenslets (HAL) to Defocus Incorporated Multiple Segments (DIMS) in European children progressive after 12M & 24M lens usage. Methods: In this retrospective study, data from 146 myopic patients (73 treated DIMS vs. 73 HAL), aged 6‐17 years (mean age ±SD, 11.3±2.36) Spherical Equivalent Refraction (SER) between ‐0.50D ‐9.25D and no associated ocular pathology were included. equivalent...
Purpose: This study aimed to assess postoperative discomfort in patients undergoing strabismus surgery under general anesthesia and identify prognostic factors influencing surgical outcomes.Material methods: An observational involving 100 was conducted. Postoperative symptoms, including headache, vomiting, ocular pain, were recorded quantified. Univariable multivariable logistic regression analyses performed factors.Results: symptoms reported 37 (37.0%). Multivariate analysis reFigvealed...