A5073813824- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatological and Skeletal Disorders
- Connective Tissue Growth Factor Research
- Bone and Joint Diseases
- Diagnosis and Treatment of Venous Diseases
- Bone health and treatments
- Autoimmune Bullous Skin Diseases
- Skin Diseases and Diabetes
- Mast cells and histamine
- Cytokine Signaling Pathways and Interactions
- Adrenal Hormones and Disorders
- Vitamin C and Antioxidants Research
- Peripheral Neuropathies and Disorders
- Bone Metabolism and Diseases
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spondyloarthritis Studies and Treatments
Ospedale Policlinico San Martino
2015-2024
University of Genoa
2015-2024
Ghent University Hospital
2014-2020
Center for Rheumatology
2015-2020
VIB-UGent Center for Inflammation Research
2020
Polyclinic Medical Center
2018-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2017
Clínica Santa María
2011
Casio (Japan)
2011
University of Bologna
1996
Systemic sclerosis (SSc) is a disorder characterized by immune system alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents common early complication, being the leading cause of mortality. Monocytes/macrophages seem to have key role in ILD. Interestingly, classically (M1) alternatively (M2) activated monocyte/macrophage phenotype categorization currently under revision. Our aim was evaluate if circulating could be used as biomarker for involvement...
Background Low-dose glucocorticoid (GC) therapy is widely used in rheumatoid arthritis (RA) but the balance of benefit and harm still unclear. Methods The GLORIA (Glucocorticoid LOw-dose RheumatoId Arthritis) pragmatic double-blind randomised trial compared 2 years prednisolone, 5 mg/day, to placebo patients aged 65+ with active RA. We allowed all cotreatments except long-term open label GC minimised exclusion criteria, tailored seniors. Benefit outcomes included disease activity (disease...
Background and aim: Vitamin D deficiency is frequently reported in patients with SARS-CoV-2 infection. The aim of this study was to correlate the 25OH-Vitamin serum concentrations clinical parameters lung involvement, elderly hospitalized for Methods: Sixty-five consecutive COVID-19 (mean age 76 ± 13 years) sixty-five sex- age-matched control subjects (CNT) were analyzed. following parameters, including comorbidities, collected at admission: type pulmonary respiratory (PaO2, SO2, PaCO2,...
The endogenous serum metabolite of vitamin D (calcitriol, 1,25(OH)2 D3 ) is considered a true steroid hormone (D hormone), and like glucocorticoids (GCs) gonadal hormones, may exert several immunomodulatory activities. Serum deficiency (25(OH) D), therefore reduced availability, risk factor for chronic/inflammatory or autoimmune conditions, including infectious diseases, type 1 diabetes, multiple sclerosis, especially rheumatic diseases (ARD). In ARD in particular, regulates both innate...
Assessment of serum 25-hydroxyvitamin D (25(OH)D) correlations with clinical parameters and evaluation the efficacy standard oral supplementation in systemic sclerosis (SSc) patients.154 SSc patients were recruited, all seasons. Serum 25(OH)D concentrations evaluated using LIAISON 25-OH (Diasorin, Italy). Medsger disease severity scale (DSS), nailfold videocapillaroscopy (NVC) instrumental exam contemplated by international guidelines performed. Drug assumption, including colecalciferol, was...
Cardiovascular morbidity and mortality appear to be increased in rheumatoid arthritis (RA), which might due prevalence of risk factors for cardiovascular disease, such as an accelerated progression atherosclerosis. Patients with active RA frequently show atherogenic lipid profile, has been linked the inflammatory reaction. Tumor necrosis factor-alpha (TNF-alpha), a pivotal proinflammatory cytokine implicated pathogenesis atherosclerosis RA, may involved development altered profile observed...
To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the number of capillaries, observable first row, 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy endothelin receptor antagonist bosentan (BOSE) synthetic analog prostacyclin PGI2 iloprost (ILO) by multiple diagnostic tools. Observed values were correlated clinical outcomes.Thirty SSc already receiving intravenous ILO (80 μg/day) for 5 continuous days (every 3 mos)...
Abstract Background Absolute nailfold capillary number should be a putative biomarker in selected rheumatic diseases but could time‐consuming and not highly repeatable. Objective To validate an automated software for absolute density evaluation, on NVC images SS c. Methods An to count ( AUTOCAPI ) had been constructed, through exploratory image set. Subsequently, application rules have created define the ROI images, training The reliability was assessed calculation of ICC between automatic...
Objective. To evaluate the longterm effects of endothelin-1 (ET-1) antagonism on peripheral blood perfusion (PBP) in patients with systemic sclerosis (SSc). Methods. Twenty-six SSc already receiving cyclic intravenous iloprost (ILO) for severe Raynaud phenomenon were enrolled. Thirteen continued treatment a further 3 years (ILO group) and 13 patients, because appearance digital ulcers, received addition bosentan (BOS; 125 mg twice/day) + BOS group). Both PBP at fingertips nailfold...
Alternatively activated (M2) macrophages are phenotypically characterized by the expression of specific markers, mainly macrophage scavenger receptors (CD204 and CD163) mannose receptor-1 (CD206), participate in fibrotic process over-producing pro-fibrotic molecules, such as transforming growth factor-beta1 (TGFbeta1) metalloproteinase (MMP)-9. Endothelin-1 (ET-1) is implicated process, exerting its effects through interaction with (ETA ETB). The study investigated possible role ET-1...
SSc patients are recognized as presenting an increased risk of altered bone mass. The aim this study was to assess the quality, by trabecular score (TBS), in correlation with different levels microvascular damage, evaluated nailfold videocapillaroscopy (NVC), and compare results regarding quality RA healthy subjects (CNT).Eighty-four patients, 98 60 CNT, were studied. BMD (g/cm2) lumbar spine (L1-L4) analysed DXA scan. Lumbar derived from each examination using TBS analysis. NVC patterns...