A5089676491- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Dermatological and Skeletal Disorders
- Diagnosis and Treatment of Venous Diseases
- Rheumatoid Arthritis Research and Therapies
- Connective Tissue Growth Factor Research
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Skin Diseases and Diabetes
- Vitamin D Research Studies
- Body Contouring and Surgery
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Lymphatic System and Diseases
- Cytokine Signaling Pathways and Interactions
- Circadian rhythm and melatonin
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Infrared Thermography in Medicine
- Stress Responses and Cortisol
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
Ospedale Policlinico San Martino
2015-2024
University of Genoa
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2022
Istituto Nazionale di Riposo e Cura per Anziani
2022
Dokuz Eylül University
2021
Center for Rheumatology
2004-2020
Hospital de Tortosa Verge de la Cinta
2020
Polyclinic Medical Center
2018
Ghent University Hospital
2012-2016
Nicolae Testemițanu State University of Medicine and Pharmacy
2012
Systemic sclerosis (SSc) is a disorder characterized by immune system alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents common early complication, being the leading cause of mortality. Monocytes/macrophages seem to have key role in ILD. Interestingly, classically (M1) alternatively (M2) activated monocyte/macrophage phenotype categorization currently under revision. Our aim was evaluate if circulating could be used as biomarker for involvement...
Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play central pathogenetic role. Recently, we graded scleroderma microangiopathy by nailfold videocapillaroscopy (NVC) into three NVC patterns (early, active late). The aim of the present study was confirm, larger number SSc patients, presence microvascular damage, detect any possible relationship between these both specific serum autoantibodies subsets cutaneous involvement.Two hundred forty-one...
Longitudinal study to define a scoring system quantify the specific capillary abnormalities, as observed by microscopy in systemic sclerosis (SSc).Ninety patients with SSc were evaluated nailfold videocapillaroscopy for an average of 72 (SD 23) months. Enlarged and giant capillaries, haemorrhages, loss disorganisation microvascular array, ramifications parameters identifying "scleroderma patterns". A semiquantitative rating scale score these altered was adopted (score 0-3). "microangiopathy...
Objective. Assessment of associations nailfold videocapillaroscopy (NVC) scleroderma (systemic sclerosis; SSc) (“early,” “active,” and “late”) with novel future severe clinical involvement in 2 independent cohorts. Methods. Sixty-six consecutive Belgian 82 Italian patients SSc underwent NVC at baseline. Images were blindly assessed classified into normal, early, active, or late pattern. Clinical evaluation was performed for 9 organ systems (general, peripheral vascular, skin, joint, muscle,...
Objective Investigation of the reliability qualitative and semiquantitative scoring nailfold videocapillaroscopy (NVC) assessment between two raters in a systemic sclerosis (SSc) cohort. Methods Two from different centres blindly assessed NVC images 71 consecutive patients with SSc qualitatively as belonging to scleroderma spectrum (SDS) category (‘early’, ‘active’, ‘late’ pattern or ‘scleroderma-like’ pattern) ‘normal’ semiquantitatively by calculating mean score for capillary loss, giant...
Background and aim: Vitamin D deficiency is frequently reported in patients with SARS-CoV-2 infection. The aim of this study was to correlate the 25OH-Vitamin serum concentrations clinical parameters lung involvement, elderly hospitalized for Methods: Sixty-five consecutive COVID-19 (mean age 76 ± 13 years) sixty-five sex- age-matched control subjects (CNT) were analyzed. following parameters, including comorbidities, collected at admission: type pulmonary respiratory (PaO2, SO2, PaCO2,...
The endogenous serum metabolite of vitamin D (calcitriol, 1,25(OH)2 D3 ) is considered a true steroid hormone (D hormone), and like glucocorticoids (GCs) gonadal hormones, may exert several immunomodulatory activities. Serum deficiency (25(OH) D), therefore reduced availability, risk factor for chronic/inflammatory or autoimmune conditions, including infectious diseases, type 1 diabetes, multiple sclerosis, especially rheumatic diseases (ARD). In ARD in particular, regulates both innate...
Assessment of serum 25-hydroxyvitamin D (25(OH)D) correlations with clinical parameters and evaluation the efficacy standard oral supplementation in systemic sclerosis (SSc) patients.154 SSc patients were recruited, all seasons. Serum 25(OH)D concentrations evaluated using LIAISON 25-OH (Diasorin, Italy). Medsger disease severity scale (DSS), nailfold videocapillaroscopy (NVC) instrumental exam contemplated by international guidelines performed. Drug assumption, including colecalciferol, was...
It is well known that some clinical signs and symptoms of rheumatoid arthritis (RA) vary within a day between days, the morning stiffness seen in patients with RA has become one diagnostic criteria disease (fig 1). 1 Among joint inflammation RA, intensity pain changes consistently as function hours day: greater after waking up than afternoon or evening. 2 In circadian variations are also found swelling finger size these phase rhythm pain.The rhythms differ by about 12 from left right hand...
To investigate the timing of transition through different patterns nailfold microvascular damage in patients with systemic sclerosis (SSc).In this medium-term longitudinal study, 38 SSc (median disease duration 12 months) early scleroderma pattern microangiopathy seen on baseline videocapillaroscopy (NVC) were followed up by NVC for a median 84 months. The evolution over time was monitored and recorded.At end followup, still that 47% patients. active 34%, late 13%, normal 5%. mean± SD...
The aim of this pilot study was to assess peripheral blood perfusion (PBP) by a new technique, the laser speckle contrast analysis (LASCA), in systemic sclerosis (SSc) patients showing different patterns nailfold microangiopathy. Correlations between LASCA and single Doppler flowmetry (LDF) were also checked.Sixty-one SSc 61 healthy subjects enrolled. PBP evaluated using LDF. Scleroderma microangiopathy evolution score (MES) assessed videocapillaroscopy (NVC).As detected LDF, lower than...
We sought to assess whether nailfold videocapillaroscopy (NVC) patterns are associated with levels of angiogenic factors in systemic sclerosis (SSc). Circulating endothelial progenitor cells (EPCs) and circulating (CECs) were measured the peripheral blood 60 consecutive SSc patients. Serum eight markers first these patients, then an independent replication cohort 43 patients case association NVC patterns. determined by four investigators blinded vascular markers. Patients late-NVC pattern...
Objective. Systemic sclerosis (SSc) is characterized by microvascular injury, fibrosis, and hypoxia of involved tissues. The vasoactive peptide endothelin-1 (ET-1) seems to be implicated in these events. Using nailfold videocapillaroscopy (NVC), we evaluated longterm effects ET-1 antagonist treatment on damage patients with SSc, over a 3-year followup period. Methods. Thirty SSc (mean age 64 ± 5 yrs, mean disease duration 8 1 yrs) were recruited during their programmed standard protocols. At...
Background Vitamin D receptor is constitutively expressed on the lymphocyte surface. Recent studies highlight that vitamin may exert actions T-cells, inhibiting Th1 and Th17 response enhancing Th2 T-regulatory (T-reg) function. Methods Thirty-four patients with systemic lupus erythematosus (SLE) were randomly enrolled in a two-year prospective study. In first year, 16 supplemented an intensive regimen of cholecalciferol (IR) (300.000 UI at baseline 50.000 UI/monthly as maintenance, 850.000...
To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the number of capillaries, observable first row, 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy endothelin receptor antagonist bosentan (BOSE) synthetic analog prostacyclin PGI2 iloprost (ILO) by multiple diagnostic tools. Observed values were correlated clinical outcomes.Thirty SSc already receiving intravenous ILO (80 μg/day) for 5 continuous days (every 3 mos)...