A5061733081- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Immune cells in cancer
- Cancer Cells and Metastasis
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Pluripotent Stem Cells Research
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Wound Healing and Treatments
- Liver physiology and pathology
King's College London
2016-2025
AstraZeneca (United Kingdom)
2023-2025
King's College Hospital NHS Foundation Trust
2022-2024
King's College Hospital
2019-2023
AstraZeneca (Sweden)
2023
Cancer Research UK
2005-2022
University College London
2003-2020
Guy's Hospital
2018-2020
University of London
2020
RELX Group (United States)
2020
The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented. However, the therapeutic benefit completely unpredictable, thus raising concerns about MSC efficacy. One affecting factors unresolved conundrum that, despite being immunosuppressive, MSCs are undetectable after administration. Therefore, understanding fate infused could help predict clinical responses. Using a murine model graft-versus-host disease (GvHD), we demonstrate that actively induced to undergo...
Background. Mesenchymal stem cells (MSCs) play a crucial role in hematopoietic development and have been shown to exert powerful immunosuppressive effect. In this study, we investigated the effect of bone marrow MSC on differentiation function peripheral blood monocytes into dendritic (DCs). Methods. Human MSCs, generated from normal marrow, were added stimulated vitro with granulocyte–macrophage colony stimulating factor interleukin-4 become DCs. Monocytes then examined for expression...
A recently discovered mutation in coagulation factor V (Arg506-->Gln, referred to as Leiden), which results resistance activated protein C, is found approximately one fifth of patients with venous thromboembolism. However, the risk recurrent thromboembolism heterozygous carriers this genetic abnormality unknown.We searched for Leiden 251 unselected a first episode symptomatic deep-vein thrombosis diagnosed by venography. The were followed prospectively mean 3.9 years determine frequency and...
Abstract Extracellular vesicles (EVs) derived from mesenchymal stem cells are promising nanotherapeutics in liver diseases due to their regenerative and immunomodulatory properties. Nevertheless, a concern has been raised regarding the rapid clearance of exogenous EVs by phagocytic cells. Here we explore impact protein corona on two culturing conditions which specific proteins acquired media were simultaneously adsorbed EV surface. Additionally, incubating with serum, simulating formation...
A phase I study was performed to determine the safety and tolerability of injecting autologous CD34(+) cells into five patients with liver insufficiency. The based on hypothesis that cell population in granulocyte colony-stimulating factor (G-CSF)-mobilized blood contains a subpopulation potential for regenerating damaged tissue. We separated candidate stem from majority (99%) by adherence tissue culture plastic. adherent nonadherent were distinct morphology, immunophenotype, gene expression...
Although it has been widely demonstrated that human mesenchymal stem cells exert potent immunosuppressive effects, there is little information as to whether more mature stromal (SC) share the same property. Accordingly, we set out test ability of SC from different tissues inhibit proliferation PBMC following polyclonal stimuli. Chondrocytes, well fibroblasts synovial joints, lung, and skin, were used a source SC. Irrespective their differentiation potential and/or content progenitor cells,...
Mesenchymal stem cells (MSC) are a type of multipotent progenitor cell, originally isolated from the bone marrow. In addition to multilineage differentiation and participation in hematopoietic niche, they exert powerful immunomodulatory effects, which include inhibition proliferation function T cells, B natural killer cells. These unique properties make MSC great interest for clinical applications tissue engineering immunosuppression. Underlying MSC-mediated mechanisms is nonspecific...