A5082312639- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Biomarkers in Disease Mechanisms
- CRISPR and Genetic Engineering
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Multiple Sclerosis Research Studies
- Peripheral Artery Disease Management
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Hematopoietic Stem Cell Transplantation
- Pregnancy and preeclampsia studies
- Mitochondrial Function and Pathology
- Paraoxonase enzyme and polymorphisms
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Transcranial Magnetic Stimulation Studies
University of Ferrara
2015-2024
Cell and Gene Therapy Catapult
2009-2023
Imperial College London
2007-2023
Morpho (United States)
2018
IRCCS Materno Infantile Burlo Garofolo
2018
University of Trieste
2015
Tecnologie Avanzate (Italy)
2014
Hammersmith Hospital
2013
University of Padua
2002-2012
The San Raffaele Telethon Institute for Gene Therapy
2009
In December 2019, a novel severe acute respiratory syndrome (SARS) from new coronavirus (SARS-CoV-2) was recognized in the city of Wuhan, China. Rapidly, it became an epidemic China and has now spread throughout world reaching pandemic proportions. High mortality rates characterize SARS-CoV-2 disease (COVID-19), which mainly affects elderly, causing unrestrained cytokines-storm subsequent pulmonary shutdown, also suspected micro thromboembolism events. At present time, no specific dedicated...
Nanomedicine, a convergence of nanotechnology and medical sciences, has unleashed transformative potential in healthcare. However, harnessing the benefits nanomedicine requires thorough understanding its regulatory landscape. An in-depth discussion considerations, including molecular safety assessment, harmonization landscape, shaping future innovation, is presented this discourse. The assessment entails evaluating interactions between nanoparticles biomolecules, ensuring compatibility at...
We report a unique mutation in the D-amino acid oxidase gene (R199W DAO) associated with classical adult onset familial amyotrophic lateral sclerosis (FALS) three generational FALS kindred, after candidate screening 14.52 cM region on chromosome 12q22-23 linked to disease. Neuronal cell lines expressing R199W DAO showed decreased viability and increased ubiquitinated aggregates compared cells wild-type protein. Similarly, lentiviral-mediated expression of primary motor neuron cultures caused...
Background Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant imatinib. Mesenchymal stromal in bone marrow may favor persistence and progression by preserving proliferation self-renewal capacities malignant progenitor cells.Design Methods BV173 or primary were co-cultured with human mesenchymal imatinib-induced cell death was then measured. The roles pro-and anti-apoptotic...
A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by integrating microcontact printing and perfusion co-culture to facilitate the of BBB function under high biological fidelity. This achieved crosslinking brain extracellular matrix (ECM) proteins transwell membrane at luminal surface adapting inlet–outlet on porous wall. While investigating anatomical hallmarks BBB, tight junction revealed tortuous zonula occludens (ZO-1), claudin expressions with...
Biotransformation refers to the metabolic conversion of endogenous and xenobiotic chemicals into more hydrophilic substances. Xenobiotic biotransformation is accomplished by a restricted number enzymes with broad substrate specificities. The xenobiotics catalyzed various enzyme systems that can be divided four categories based on reaction they catalyze. primary concentration in cytochrome P450, while CYP responsible for are located within hepatic endoplasmic reticulum (microsomes)....
The importance of host genetics and demography in coronavirus disease 2019 (COVID-19) is a crucial aspect infection, prognosis associated case fatality rate. Individual genetic landscapes can contribute to understand Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) burden give information on how fight virus spreading the severe acute respiratory distress syndrome (ARDS). spread pathogenicity have become pandemic specific geographic areas ethnicities. Interestingly, SARS-CoV-2...
Background The inflammatory properties of vein endothelium in relation to chronic venous disease (CVD) have been poorly investigated. Therefore, new insights on the characteristics large would increase our knowledge vessel physiopathology. Methodology/Principal Findings Surgical specimens veins were obtained from tertiary network (R3) and/or saphenous (SF) patients affected by CVD and control individuals. Highly purified endothelial cell (VEC) cultures characterized for morphological,...
Cognitive impairments of different aetiology share alterations in iron and lipid homeostasis with mutual relationships. Since cholesterol accumulation impact on neurodegenerative disease, the associated gene variants are appealing candidate targets for risk disease progression assessment. In this light, we explored role common single nucleotide polymorphisms (SNPs) main genes lipoprotein transporter (APOE) a cohort 765 patients dementia origin: Alzheimer’s (AD) n = 276; vascular (VaD), 255;...
T-cell receptor (TCR) gene transfer for cancer immunotherapy is limited by the availability of large numbers tumor-specific T cells. TCR alpha and beta chains were isolated from a highly lytic HLA-A2-restricted cytotoxic lymphocyte (CTL) clone recognizing melanoma-associated Melan-A/MART-1 antigen inserted into lentiviral vector carrying bidirectional promoter capable robust coordinated expression two transgenes. Lentiviral vector-based delivery systems have shown increased efficiency...
Abstract Spontaneous abortion is a pregnancy complication characterized by complex and multifactorial etiology. About 5% of childbearing women are globally affected early loss (EPL) most them experience recurrence (RPL). Epigenetic mechanisms controlled inflammation crucial for maintenance genetic predispositions may increase the risk affecting maternal–fetal crosstalk. Combined analyses global methylation, inherited contribute to define etiopathogenesis. LINE-1 epigenetic regulation plays...
This article explores the transformative advances in soft machines, where biology, materials science, and engineering have converged. We discuss remarkable adaptability versatility of drawing inspiration from nature's elegant solutions. From intricate movements octopus tentacles to resilience an elephant trunk, nature provides a wealth for designing robots capable navigating complex environments with grace efficiency. Central this advancement is ongoing research bioinspired materials, which...