Vincenzo Brescia Morra
A5101910398- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Acute Lymphoblastic Leukemia research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- Lysosomal Storage Disorders Research
- Cytokine Signaling Pathways and Interactions
- Advanced MRI Techniques and Applications
- Health Literacy and Information Accessibility
- Social Media in Health Education
- Hepatitis B Virus Studies
- T-cell and B-cell Immunology
- Bacterial Infections and Vaccines
- Powdery Mildew Fungal Diseases
- Misinformation and Its Impacts
- Family Support in Illness
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Federico II University Hospital
2016-2025
University of Naples Federico II
2013-2025
Centre for Studies in Economics and Finance
2021
National Hospital for Neurology and Neurosurgery
2021
University College London
2021
Medical University of Vienna
2021
National Institute for Health Research
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2021
University of Campania "Luigi Vanvitelli"
2020
Astronomical Observatory of Capodimonte
2017
Abstract Background ChatGPT is an open-source natural language processing software that replies to users’ queries. We conducted a cross-sectional study assess people living with Multiple Sclerosis’ (PwMS) preferences, satisfaction, and empathy toward two alternate responses four frequently-asked questions, one authored by group of neurologists, the other ChatGPT. Methods An online form was sent through digital communication platforms. PwMS were blind author each response asked express their...
Background: Optical coherence tomography (OCT) angiography is a new method to assess the density of vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology. Objective: To presence MS and evaluate their correlation disease features. Methods: A total 50 patients with without history optic neuritis (ON) 46 healthy subjects were included. All underwent spectral domain (SD)-OCT OCT angiography. Clinical history, Expanded Disability Status Scale...
An ever-expanding number of disease-modifying drugs for multiple sclerosis have become available in recent years, after demonstrating efficacy clinical trials. In the real-world setting, however, are prescribed patient populations that differ from those included pivotal studies, where extreme age patients usually excluded or under-represented. this multicentre, observational, retrospective Italian cohort study, we evaluated treatment exposure three cohorts with relapsing-remitting defined by...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
To describe the effect of natalizumab in treatment subjects with active multiple sclerosis (MS) treated before age 18 years.Nineteen pediatric MS (mean 14.6 +/- 2.2 years, mean number attacks 5.2 1.9 during pretreatment phase 27.7 19.7 months, median Expanded Disability Status Scale score [EDSS] 2.5, range 1.0-5.0) were at dose 300 mg every 28 days. After initiation, patients reassessed clinically month; brain MRI was performed baseline and 6 months.Patients received a 15 infusions (range...
In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim this study was exploring relationship between disability, strategies, daily life reorganization neuropsychiatric symptoms in an Italian MS population during lockdown, order to identify potentially modifiable that could inform clinical management people with MS.We explored distress, disability strategies under lockdown....
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
Availability of new disease-modifying therapies (DMTs) and changes therapeutic paradigms have led to a general improvement multiple sclerosis (MS) prognosis in adults. It is still unclear whether this also involves patients with pediatric-onset MS (POMS), whose early management more challenging.To evaluate the POMS over time association managing standards.Retrospective, multicenter, observational study. Data were extracted collected May 2019 from Italian Registry, digital database including...
<h3>Background and Objectives</h3> Several studies have assessed risk factors associated with the severity of COVID-19 outcomes in people multiple sclerosis (PwMS). The potential role disease-modifying therapies (DMTs) demographic clinical on acquiring SARS-CoV-2 infection has not been evaluated so far. objective this study was to assess contracting PwMS by using data collected Italian MS Register (IMSR). <h3>Methods</h3> A case-control (1:2) set up. Cases included a confirmed diagnosis...
<h3>Objective</h3> To evaluate the safety and efficacy of cladribine tablets in patients still experiencing active relapsing MS despite interferon (IFN)-β treatment. <h3>Methods</h3> A 96-week phase II study, randomizing treated with IFN-β to 3.5 mg/kg/IFN-β or placebo/IFN-β. Patients were receive placebo/IFN-β a 2:1 ratio (n = 172) exploratory outcomes being assessed. <h3>Results</h3> Adverse events (AEs) serious AEs similar across treatment groups, except lymphopenia. Fifty 124 (40.3%)...
Background The approval of Sativex for the management multiple sclerosis (MS) spasticity opened a new opportunity to many patients. In Italy, healthcare payer can be fully reimbursed by involved pharma company with cost treatment patients not responding after 4 week (28 days) trial period (Payment Results, PbR), and 50% 6 weeks (42 other discontinuing (Cost Sharing, CS). aim our study was describe discontinuation profile from large population treated Italian MS Methods We collected data 30...
Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) progressive MS. Methods: This a multicenter, retrospective study on consecutive MS patients treated with 22 Italian 1 Swiss centers. Relapse rate, time first relapse, Expanded Disability Status Scale (EDSS) progression, incidence...
Modifications of magnetic susceptibility have been consistently demonstrated in the subcortical gray matter MS patients, but some uncertainties remain concerning underlying neurobiological processes and their clinical relevance. We applied quantitative mapping longitudinal relaxation rate relaxometry to clarify relative contribution atrophy iron myelin changes deep damage disability MS.Quantitative maps were computed for 91 patients 55 healthy controls from MR images acquired at 3T. Applying...
To stratify patients with multiple sclerosis (pwMS) based on brain MRI-derived volumetric features using unsupervised machine learning.The 3-T MRIs of relapsing-remitting pwMS including 3D-T1w and FLAIR-T2w sequences were retrospectively collected, along Expanded Disability Status Scale (EDSS) scores long-term (10 ± 2 years) clinical outcomes (EDSS, cognition, progressive course). From the MRIs, volumes demyelinating lesions 116 atlas-defined gray matter regions automatically segmented...
Importance Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years age, it has been suggested that people pediatric-onset MS (POMS) are protected against disability because greater capacity for repair. Objective To assess the incidence and factors associated progression independent relapse activity (PIRA) relapse-associated worsening (RAW) in POMS compared typical adult-onset (AOMS) late-onset (LOMS). Design, Setting, Participants This cohort study on...
In patients with relapsing-remitting MS (RRMS) fingolimod prevents disease relapses and delays disability progression. First dose administration of is associated a transient, dose-dependent decrease in heart rate (HR) the 6 hours after drug intake. The aim study to assess safety tolerability first cohort Italian RRMS without alternative therapeutic options. Open-label, single arm, multicentre study. After fingolimod, were observed for had their vital signs monitored hourly. Extended on-site...
Social media are a vital link for people with health concerns who find in Web communities valid and comforting source information exchange, debate, knowledge enrichment. This aspect is important affected by chronic diseases like multiple sclerosis (MS), very well informed about the disease but vulnerable to hopes of being cured or saved therapies whose efficacy not always scientifically proven. To improve health-related coping social interaction MS, we created an MS network...