Rocco Totaro
A5056898234- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Rheumatoid Arthritis Research and Therapies
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Acute Lymphoblastic Leukemia research
- Migraine and Headache Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Sclerosis and Related Diseases
- Acute Ischemic Stroke Management
- Autoimmune and Inflammatory Disorders Research
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Cardiovascular Health and Disease Prevention
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Optical Imaging and Spectroscopy Techniques
San Salvatore Hospital
2016-2025
University of L'Aquila
2009-2024
Multiple Sclerosis Foundation
2021-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2022
Mario Negri Institute for Pharmacological Research
2022
Policlinico San Matteo Fondazione
2020
Istituto Neurologico Mediterraneo
2015
Ospedali Riuniti di Ancona
2015
Ospedali Riuniti di Foggia
2015
Fondazione IRCCS Istituto Neurologico Carlo Besta
2014
Background and Purpose— Atrial fibrillation (AF) is a major risk factor for ischemic stroke its prevalence increases steeply with age. Population-based data on influence outcome are scarce. Methods— We evaluated the of AF prognosis in patients first-ever from population-based registry. Results— The presence at onset during acute phase was confirmed by standard electrocardiogram 869 (24.6%) 3530 stroke. With respect to without arrhythmia, those were more frequently women, aged 80 years older,...
Disability accrual in multiple sclerosis may occur as relapse-associated worsening or progression independent of relapse activity. The role activity early is yet to be established. objective this multicentre, observational, retrospective cohort study was investigate the contribution and confirmed disability accumulation patients with clinically isolated syndrome relapsing-remitting sclerosis, assessed within one year from onset follow-up ≥5 years (n = 5169). Data were extracted Italian...
<b>Objective: </b> To evaluate incidence and prognosis of lacunar stroke in a prospective, population-based patient registry. <b>Methods: The authors included first-ever strokes occurring between 1994 1998. They assessed incidence, risk factors, mortality, recurrence patients with stroke. <b>Results: identified 491 (15.3%) (252 men 239 women) 2,153 (67.3%) nonlacunar (998 1,155 women). Crude annual rate for was 33.0/100,000 (95% CI 30.2 to 36.0). At the univariate logistic regression...
To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) all pregnancies occurring women with multiple sclerosis (MS) during the study period, a specific focus on risk of spontaneous abortion.In this cohort study, data were gathered through standardized, semi-structured interview. Patients who discontinued IFNβ less than 4 weeks from conception (exposed) compared those had drug at least or never treated (not exposed). Possible confounders handled multivariate...
<h3>Objective:</h3> To assess the relationship between breastfeeding and risk of puerperal relapses in a large cohort patients with multiple sclerosis (MS). <h3>Methods:</h3> We prospectively followed-up pregnancies occurring 2002 2008 women MS, recruited from 21 Italian MS centers, gathered data on through standardized interview. The after delivery was assessed using Cox regression analysis. <h3>Results:</h3> A total 302 out 423 298 resulted full-term deliveries. Patients were followed up...
To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), a specific focus on spontaneous abortion (SA) and congenital anomalies (CA).Data of all pregnancies occurring between 2009 2015 patients MS treated referring 19 participating sites were collected compared those untreated injectable immunomodulatory agents. Rates SA CA also reported the Italian population. Multivariable logistic linear regression models performed.A total 92 tracked 83 women. In...
No consensus exists on how aggressively to treat relapsing-remitting multiple sclerosis (RRMS) nor the timing of treatment. The objective this study was evaluate disability trajectories in RRMS patients treated with an early intensive treatment (EIT) or a moderate-efficacy followed by escalation higher-efficacy disease modifying therapy (ESC).RRMS ⩾5-year follow-up and ⩾3 visits after (DMT) start were selected from Italian MS Registry. EIT group included who received as first DMT fingolimod,...
An ever-expanding number of disease-modifying drugs for multiple sclerosis have become available in recent years, after demonstrating efficacy clinical trials. In the real-world setting, however, are prescribed patient populations that differ from those included pivotal studies, where extreme age patients usually excluded or under-represented. this multicentre, observational, retrospective Italian cohort study, we evaluated treatment exposure three cohorts with relapsing-remitting defined by...
Background and Purpose —Stroke type in the young may influence outcome have a dramatic impact on quality of life survivors. This study aimed to evaluate incidence prognosis first-ever stroke make comparisons with older patients within well-defined population. Methods —All strokes occurring L’Aquila district, central Italy, were traced by active monitoring inpatient outpatient health services. Incidence rates standardized 1996 European population according direct method. Long-term survival...
Abstract Background Few studies have systematically addressed the role of epidural analgesia and caesarean delivery in predicting post-partum disease activity women with Multiple Sclerosis (MS). The objective this study was to assess impact (EA) (CD) on risk relapses disability MS. Methods In context an Italian prospective safety immunomodulators pregnancy, we included pregnancies occurred between 2002 2008 MS regularly followed-up 21 centers. Data were gathered through a standardized,...
Abstract Background Only few studies have assessed safety of in utero exposure to glatiramer acetate (GA). Following a previous study assessing the interferon beta (IFNB) pregnancy multiple sclerosis (MS), we aimed assess and fetal outcomes after GA, using same dataset, with specific focus on risk spontaneous abortion. Materials methods We recruited MS patients, prospectively followed-up 21 Italian Centres, for whom was recorded period 2002–2008. Patients were divided into 2 groups:...
<h3>Objective</h3> To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in year after delivery women with multiple sclerosis (MS). <h3>Methods</h3> We prospectively followed-up pregnancies occurring between 2002 2008 MS, recruited from 21 Italian MS centres. The risk relapses was assessed using time-dependent Cox regression analysis. <h3>Results</h3> 350 out 423 were (pregnancies not resulting live birth a postpartum follow-up period shorter than 1...
<h3>Objective</h3> To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). <h3>Methods</h3> Data all pregnancies occurring between 2009 and 2015 patients MS treated referring to 19 participating sites were collected compared those untreated injectable immunomodulatory agents through a 2-factor repeated measures analysis. Predictors activity assessed stepwise multivariable logistic regression models. <h3>Results</h3> A...
Availability of new disease-modifying therapies (DMTs) and changes therapeutic paradigms have led to a general improvement multiple sclerosis (MS) prognosis in adults. It is still unclear whether this also involves patients with pediatric-onset MS (POMS), whose early management more challenging.To evaluate the POMS over time association managing standards.Retrospective, multicenter, observational study. Data were extracted collected May 2019 from Italian Registry, digital database including...
<h3>Background and Objectives</h3> Several studies have assessed risk factors associated with the severity of COVID-19 outcomes in people multiple sclerosis (PwMS). The potential role disease-modifying therapies (DMTs) demographic clinical on acquiring SARS-CoV-2 infection has not been evaluated so far. objective this study was to assess contracting PwMS by using data collected Italian MS Register (IMSR). <h3>Methods</h3> A case-control (1:2) set up. Cases included a confirmed diagnosis...
Abstract Objectives We investigated the occurrence and relative contribution of relapse-associated worsening (RAW) progression independent relapse activity (PIRA) to confirmed disability accrual (CDA) transition secondary (SP) in relapsing multiple sclerosis (MS). Methods Relapsing-onset MS patients with follow-up > / = 5 years (16,130) were extracted from Italian Registry. CDA was a 6-month increase Expanded Disability Status Scale (EDSS) score. Sustained accumulation (SDA) no EDSS...
Background and Purpose —Prognosis of ischemic stroke in young adults is reported as favorable, transient attack (TIA) commonly considered a benign event. We investigated long-term outcome prognostic predictors cerebral ischemia patients under 45 years age. Methods —Three hundred thirty-three aged 15 to 44 who suffered from first-ever TIA or were prospectively followed up with annual clinical evaluation complete phone interview. End points the composite event stroke, myocardial infarction,...
Importance Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years age, it has been suggested that people pediatric-onset MS (POMS) are protected against disability because greater capacity for repair. Objective To assess the incidence and factors associated progression independent relapse activity (PIRA) relapse-associated worsening (RAW) in POMS compared typical adult-onset (AOMS) late-onset (LOMS). Design, Setting, Participants This cohort study on...
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
Objective Assessing the risk of clinical and radiological reactivation during pregnancy post partum in women with multiple sclerosis (MS) treated natalizumab (NTZ) throughout (LONG_EXP) compared interrupting treatment before (NO_EXP) within >−30 days ≤90 from conception (SHORT_EXP), describing newborns’ outcomes. Methods Maternal outcomes obstetric fetal were retrospectively collected among groups (NO_EXP, SHORT_EXP, LONG_EXP). Predictors investigated through univariable multivariable...
To evaluate incidence, case fatalities and prognosis of subarachnoid hemorrhage (SAH).Prospective population-based registry (1994-1998) including patients with a first-ever stroke followed up to 10 years.In 5-year period we included 118 (55 men 63 women; mean age +/- SD 60.7 15.9 years) an SAH. The crude annual incidence rate was 7.93 cases per 100,000 inhabitants (95% CI 6.46-9.63), 7.60 when standardized the 2006 European population 5.27 2005 world population. 7-day case-fatality 16.1%...
Most of Multiple Sclerosis (MS) patients undergo disease modifying drug (DMD) therapy at childbearing age. The objective this prospective, collaborative study, was to assess outcomes pregnancies fathered by MS undergoing DMD. Structured interviews on gathered in the Italian Pregnancy Dataset were collected; divided according father exposure or unexposure DMD time procreation. Treatment compared with multivariable logistic and linear models. Seventy-eight tracked. Forty-five taking conception...
Tumefactive multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. It has recently been described as a rare subtype (MS) characterised by appearance solitary or space-occupying lesions associated with imaging characteristics mimicking neoplasm. Atypical features include plaque size >2 cm mass effect, oedema, and/or ring enhancement on magnetic resonance (MR) images. This study retrospective review designed to evaluate prevalence tumefactive plaques in...