A5044701851- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- EEG and Brain-Computer Interfaces
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Restless Legs Syndrome Research
- Allergic Rhinitis and Sensitization
- Polyomavirus and related diseases
- Genetic Neurodegenerative Diseases
- Contact Dermatitis and Allergies
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Sleep and Work-Related Fatigue
- Systemic Lupus Erythematosus Research
- Neurological Complications and Syndromes
- Drug Transport and Resistance Mechanisms
- Electrolyte and hormonal disorders
- Amyotrophic Lateral Sclerosis Research
- Migraine and Headache Studies
- Visual perception and processing mechanisms
University of Pisa
2013-2024
Istituto delle Scienze Neurologiche di Bologna
2003
Neuroscience Institute
2001
Neurosciences Institute
2001
University of Bari Aldo Moro
1997
University of Genoa
1980-1993
Sapienza University of Rome
1992
University of Bologna
1988-1990
University of Pavia
1989
Sanofi (Mexico)
1988
The increased tendency to fall asleep during the daytime together with wakefulness night has been demonstrated in patients advanced Alzheimer's disease (AD). aim of this study was assess sleep propensity a cohort mild/moderate AD and correlate it cognitive impairment. Twenty drug-free meeting NINCDS-ADRDA criteria for probable were evaluated. According their Clinical Dementia Rating scores, subjects classified into mild (CDR1; n=11) moderate (CDR2; n=9) dementia patients. A group 12 healthy...
To assess longitudinally cognitive functioning in relapsing-remitting multiple sclerosis (RRMS) patients and its relationship with clinical MRI variables.Early RRMS matched healthy controls were assessed parallel three testing sessions over 3 years, using the Rao's Brief Repeatable Battery of Neuropsychological Tests. Patients also underwent an analysis T2-weighted lesion volume (T2LV), number gadolinium-enhanced lesions whole brain atrophy. Forty-nine (mean age 36.9 ± 8.9 years; mean...
To verify the existence of a symptomatic form restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and identify possible associated risk factors. Prospective, multicenter, case-control epidemiologic survey. Settings: Twenty sleep centers certified by Italian Association Sleep Medicine. Eight hundred sixty-one patients affected MS 649 control subjects. N/A. Data regarding demographic clinical factors, presence severity RLS, results hematologic tests, visual analysis cerebrospinal...
Summary Objective To evaluate whether vagus nerve stimulation (VNS) as adjunct to best medical practice (VNS + BMP) is superior BMP alone in improving long‐term health‐related quality of life (HRQoL). Methods PuLsE (Open P rospective Randomized L ong‐term E ffectiveness) was a prospective, randomized, parallel‐group, open‐label, and effectiveness study (conducted at 28 sites Europe Canada). Adults with pharmacoresistant focal seizures (n = 112) received VNS or (1:1 ratio). Medications...
Abstract Objective To assess the effects of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) on simulated car driving ability. Methods Twenty patients with a probable AD mild severity (Clinical Dementia Rating, CDR = 1) were compared 20 subjects MCI (CD 0.5), group age‐matched neurologically normal controls simulation task. Measures competence included length run, number infractions (omission stop at pedestrian crossings, speed limits violation), stops traffic lights, mean time...
To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), a specific focus on spontaneous abortion (SA) and congenital anomalies (CA).Data of all pregnancies occurring between 2009 2015 patients MS treated referring 19 participating sites were collected compared those untreated injectable immunomodulatory agents. Rates SA CA also reported the Italian population. Multivariable logistic linear regression models performed.A total 92 tracked 83 women. In...
<h3>Background</h3> The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity many patients. aim our study was to describe Sativex effectiveness adverse events profile in large population Italian patients with MS daily practice setting. <h3>Methods</h3> We collected data all starting between January 2014 February 2015 from mandatory medicines agency (AIFA)...
Objectives: To assess the safety of citalopram as a treatment depression in patients with epilepsy. Methods: This is an open, multicentered, uncontrolled study. Depressed epileptic on antiepileptic drugs (AEDs) took part Patients who had mild frequency seizures 4 previous months underwent (20 mg/d) for consecutive months. A change seizure from baseline was chosen primary measure and efficacy against depressive symptoms taken secondary measure. Depression rated using Montgomery–Åsberg Zung...
<h3>Objective</h3> To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). <h3>Methods</h3> Data all pregnancies occurring between 2009 and 2015 patients MS treated referring to 19 participating sites were collected compared those untreated injectable immunomodulatory agents through a 2-factor repeated measures analysis. Predictors activity assessed stepwise multivariable logistic regression models. <h3>Results</h3> A...
Conflicting data have been reported on the association between interferon (IFN)-beta therapy of multiple sclerosis (MS) patients and thyroid disease development.The goals this study are as follows: to assess actual occurrence dysfunction autoimmunity during long-term IFN-beta therapy; establish possible presence predictive factors for development duration; suggest an effective follow-up protocol receiving therapy.A total 106 MS (76 women) underwent 1a or 1b up 84 months (median, 42 months)....
A splice site variation (c.603-91G>A or rs3812718) in the SCN1A gene has been claimed to influence efficacy and dose requirements of carbamazepine phenytoin. We investigated relationship between c.603-91G>A polymorphism response antiepileptic drugs (AEDs) 482 patients with drug-resistant 401 drug-responsive focal epilepsy. Most commonly used AEDs were oxcarbazepine. The distribution genotypes was similar among subjects, both entire population groups treated There no association genotype...
The role of cognitive impairment in multiple sclerosis is now widely recognized. However, there a dearth research on variability and practice effects neuropsychological measures when repeated over time. objective was to assess reliability for Rao’s Brief Repeatable Battery neurophysiological tests the Stroop Test, provide data correction serial assessments.In 54 healthy controls (34 women, mean age 38.3 ± 9.1 years, education 12.9 3.3 years), Test were administered 3 times with an 18-month...
Before the discovery of myotonic dystrophy (DM) gene, DM epidemiological rates could not be accurately estimated. The aim this study was to calculate prevalence in Padova (North‐East Italy) and four provinces North‐West Tuscany (Central and, as 30 June 1999, do so using molecular genetic testing. A minimum rate 9.31×10 −5 inhabitants found, consistent with worldwide, more than two times high those previous studies conducted same areas during era prior This study, first Italy since underlines...
Summary: Purpose: Limited research has focused to date on objective neurophysiological evaluation of daytime sleepiness in patients treated with newer antiepileptic drugs (AEDs), especially when used as monotherapy. This study was aimed at assessing occurrence newly diagnosed, drug‐naïve partial epilepsy receiving initial topiramate (TPM) Methods: Daytime vigilance assessed 14 consecutive, diagnosed and never medicated adult focal epilepsy, monotherapy TPM. At baseline 2 months after slowly...
Twenty-five adult epileptic patients who had shown a satisfactory clinical response to add-on vigabatrin under placebo-controlled conditions continued on long-term treatment for up 47 months (median 22 months). The initially favourable therapeutic was generally maintained throughout the observation period with an overall good tolerance. No evidence of neurotoxicity detected by multimodal evoked potentials monitoring.