A5088119523- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- Metabolism and Genetic Disorders
- Neurogenetic and Muscular Disorders Research
- Neurological disorders and treatments
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Wakefulness Research
- Diabetes Treatment and Management
- Diet and metabolism studies
- Hereditary Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Dementia and Cognitive Impairment Research
- SARS-CoV-2 and COVID-19 Research
- Artificial Intelligence in Healthcare
- Sleep and related disorders
- Hepatitis C virus research
- Neurological diseases and metabolism
- Monoclonal and Polyclonal Antibodies Research
University of Pisa
2016-2025
Azienda Ospedaliera Universitaria Pisana
2019-2024
Prevention of Organ Failure
2021
ASL Roma
2010
Noran Neurological Clinic
2003
Sapienza University of Rome
2001
Anna University, Chennai
1999
University of Sassari
1991
University of Ferrara
1982
ALS is a devastating neurodegenerative disorder with no effective treatment. In the present study, we found that daily doses of lithium, leading to plasma levels ranging from 0.4 0.8 mEq/liter, delay disease progression in human patients affected by ALS. None treated lithium died during 15 months follow-up, and was markedly attenuated when compared age-, duration-, sex-matched control riluzole for same amount time. parallel study on genetic animal model, G93A mouse, marked neuroprotection...
The increased tendency to fall asleep during the daytime together with wakefulness night has been demonstrated in patients advanced Alzheimer's disease (AD). aim of this study was assess sleep propensity a cohort mild/moderate AD and correlate it cognitive impairment. Twenty drug-free meeting NINCDS-ADRDA criteria for probable were evaluated. According their Clinical Dementia Rating scores, subjects classified into mild (CDR1; n=11) moderate (CDR2; n=9) dementia patients. A group 12 healthy...
Alterations in muscle structure and function have been reported overt hypothyroidism, with decreased activity of enzymes involved anaerobic oxidative glucose metabolism. To test whether similar changes energy metabolism are present subclinical hypothyroidism (sHT), we studied 12 patients sHT who complained mild neuromuscular symptoms. The control group included 10 sex- age-matched healthy volunteers. Skeletal lactate pyruvate production were determined the resting state during dynamic arm...
Renal disease in type 2 diabetes mellitus (T2DM) is associated with excess morbidity/mortality. Although estimated glomerular filtration rate (eGFR) and albuminuria are routine for assessing renal impairment, novel biomarkers could improve risk stratification prediction.To identify specific of progression dysfunction.Prospective observational.Academic clinics.A total 286 T2DM patients (age, 62 ± 8 y; glycosylated hemoglobin, 7.2 0.9%; eGFR, 85 20 mL · min(-1) 1.73 m(2)).None.Progression eGFR...
Dysregulated production of cytokines has a critical role in systemic lupus. The aim this work is to identify, by comprehensive analysis IL-1 family and receptors serum, correlation between cytokines/receptors’ levels the clinical serological features disease. A full evaluation was performed 74 patients with lupus erythematosus (SLE). C3, C4, anti-dsDNA anti-C1q antibodies were measured. Cytokines (IL-1α, IL-1β, IL-33, IL-18), soluble (sIL-1R1, sIL-1R2, sIL-1R3, ST2/sIL-1R4) antagonists...
OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). computed tomography angiography (CCTA) provides detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that protein panel differentially associated T2D CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis Outlier Subjects: Protective Novel Individual Risk Factors Evaluation—a cohort...
Abstract Background Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer’s disease (AD). The impact biological factors on their plasma concentrations in individuals with subjective memory complaints (SMC) has been poorly explored. We longitudinally investigate the effect sex, age, APOE ε4 allele, comorbidities, brain amyloid-β (Aβ) burden, cognitive scores NFL t-Tau cognitively healthy SMC, a condition associated AD...
SLE is an autoimmune disease that predominantly affects women. As most epidemiological and interventional studies are on populations with a clear female prevalence, the influence of gender in course, drug response damage accrual yet to be fully explored comprehended.To describe differences comorbidities, use medications long-term outcomes large cohort patients SLE.Retrospective gender-based analysis prospectively collected data from monocentric Caucasian at least 1 year follow-up.417 were...
Conflicting data have been reported on the association between interferon (IFN)-beta therapy of multiple sclerosis (MS) patients and thyroid disease development.The goals this study are as follows: to assess actual occurrence dysfunction autoimmunity during long-term IFN-beta therapy; establish possible presence predictive factors for development duration; suggest an effective follow-up protocol receiving therapy.A total 106 MS (76 women) underwent 1a or 1b up 84 months (median, 42 months)....
Abstract Metronomic, or continuous low-dose, chemotherapy can inhibit tumor growth via inhibition angiogenesis and immune system activation. At AACR 2024, we reported multiplex analysis of 75 cytokines in 34 out 38 patients with gastrointestinal (GI) tumors, who were evaluated a phase II clinical trial metronomic UFT (a 5-fluorouracil prodrug; 100 mg/twice per day p.o.) cyclophosphamide (an i.v. bolus on 1 500mg/mq2 then 50 mg/day plus celecoxib (200 p.o.); the COMET (CLINICAL ID...
Abstract We previously reported a metronomic chemotherapy regimen (UFT, 5-fluorouracil prodrug; 100 mg/twice per day p.o.; plus cyclophosphamide as an i.v. bolus on 1 and then 50 mg/day celecoxib 200 p.o.); evaluated in the COMET trial (ID NCT02926911; Allegrini et al. Angiogenesis 2012: 15(2):275-86) of GI cancer patients. At AACR 2024 we analysis 75 cytokines plasma these Here, report levels 22 not cytokines, analyzed for clinical correlations this trial, 34 out 38 used AI to perform part...
To evaluate the changes in renal endpoints type 2 diabetes patients treated with dapagliflozin versus other glucose-lowering medications routine clinical practice.DARWIN-T2D was a retrospective study conducted at 46 outpatient clinics Italy. An automated software collected data on 17 285 who received dapagliflozin, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, or gliclazide, 6751 of whom had follow-up visit. We analysed albumin excretion rate (AER) and...
Before the discovery of myotonic dystrophy (DM) gene, DM epidemiological rates could not be accurately estimated. The aim this study was to calculate prevalence in Padova (North‐East Italy) and four provinces North‐West Tuscany (Central and, as 30 June 1999, do so using molecular genetic testing. A minimum rate 9.31×10 −5 inhabitants found, consistent with worldwide, more than two times high those previous studies conducted same areas during era prior This study, first Italy since underlines...
Summary: Purpose: Limited research has focused to date on objective neurophysiological evaluation of daytime sleepiness in patients treated with newer antiepileptic drugs (AEDs), especially when used as monotherapy. This study was aimed at assessing occurrence newly diagnosed, drug‐naïve partial epilepsy receiving initial topiramate (TPM) Methods: Daytime vigilance assessed 14 consecutive, diagnosed and never medicated adult focal epilepsy, monotherapy TPM. At baseline 2 months after slowly...