A5057246307- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune responses and vaccinations
- Nanoparticles: synthesis and applications
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Toxin Mechanisms and Immunotoxins
- Reproductive System and Pregnancy
- Antimicrobial Peptides and Activities
- Macrophage Migration Inhibitory Factor
- Viral gastroenteritis research and epidemiology
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Urticaria and Related Conditions
- NF-κB Signaling Pathways
- Systemic Lupus Erythematosus Research
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
Shenzhen Institutes of Advanced Technology
2021-2025
Chinese Academy of Sciences
2021-2025
Stazione Zoologica Anton Dohrn
2018-2024
National Research Council
2015-2024
Shenzhen University
2024
Shenzhen Technology University
2024
Institute of Protein Biochemistry
2014-2023
Institute of Cell Biology and Neurobiology
2019-2023
State Key Laboratory of Synthetic Chemistry
2022-2023
Boston Children's Hospital
2021
Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 tumors there a correlation observed between activity macrophage content neoplastic tissues. Tumor-derived chemoattractants appear to participate the regulation tumor-associated macrophages.
Remarkable progress has recently been made in the synthesis and characterization of engineered nanoparticles for imaging treatment cancers, resulting several promising candidates clinical trials. Despite these advances, applications nanoparticle-based therapeutic/imaging agents remain limited by biological, immunological, translational barriers. In order to overcome existing status quo drug delivery, there is a need open frank discussion nanomedicine community on what needed make qualitative...
With the increasing use of nanomaterials, need for methods and assays to examine their immunosafety is becoming urgent, in particular nanomaterials that are deliberately administered human subjects (as case nanomedicines). To obtain reliable results, standardised vitro immunotoxicological tests should be used determine effects engineered nanoparticles on immune responses. However, before can standardised, it important suitable established validated. In a collaborative work between European...
Normal peritoneal M phi of C3H/HeN mice were able to suppress lymphocyte proliferation in a dose-dependent fashion when added Con A-pulsed spleen cell cultures. However, phi-suppressive activity could be partially or completely reduced by vitro pre-exposure nonimmune IFN-alpha immune recombinant IFN-gamma. For both and IFN-gamma, reduction suppression was marginal at 10(1) U/ml became highly significant 10(2) 10(3)/ml. The ability IFN-gamma modulate appears related distinct mechanisms. In...
Bringing together topic-related European Union (EU)-funded projects, the so-called “NanoSafety Cluster” aims at identifying key areas for further research on risk assessment procedures nanomaterials (NM). The outcome of NanoSafety Cluster Working Group 10, this commentary presents a vision concern-driven integrated approaches (eco-)toxicological testing and (IATA) NM. Such should start out by determining concerns, i.e., specific information needs given NM based realistic exposure scenarios....
Although the mechanisms underlying AD neurodegeneration are not fully understood, it is now recognised that inflammation could play a crucial role in initiation and progression of neurodegeneration. A neuro-inflammatory network, based on anomalous activation microglial cells, includes production number inflammatory cytokines both locally systemically. These may serve as diagnostic markers or therapeutic targets for We have measured levels inflammation-related receptors IL-1 family serum...
OPINION article Front. Immunol., 19 April 2018Sec. Inflammation Volume 9 - 2018 | https://doi.org/10.3389/fimmu.2018.00799