A5056750583- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Immunotoxicology and immune responses
- Antimicrobial Peptides and Activities
- Inhalation and Respiratory Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA and protein synthesis mechanisms
- SARS-CoV-2 and COVID-19 Research
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Bacteriophages and microbial interactions
- Complement system in diseases
- Advanced Nanomaterials in Catalysis
- Immune Cell Function and Interaction
- Advanced Drug Delivery Systems
- Platelet Disorders and Treatments
- Computational Drug Discovery Methods
- Blood properties and coagulation
National Cancer Institute
2010-2025
Frederick National Laboratory for Cancer Research
2016-2025
St Petersburg University
2025
National Cancer Institute
2025
Leidos (United States)
2013-2019
Leidos Biomedical Research Inc. (United States)
2014-2017
Weatherford College
2015
Science Applications International Corporation (United States)
2007-2013
The University of Texas Southwestern Medical Center
2010
Texas A&M University
2010
Hemolysis (destruction of red blood cells) in vivo can lead to anemia, jaundice, and other pathological conditions; therefore the hemolytic potential all intravenously administered pharmaceuticals must be evaluated. Nanotechnology-derived devices drug carriers are emerging as alternatives conventional small-molecule drugs, vitro evaluation their biocompatibility with components is a necessary part early preclinical development. The small size unique physicochemical properties nanoparticles...
Remarkable progress has recently been made in the synthesis and characterization of engineered nanoparticles for imaging treatment cancers, resulting several promising candidates clinical trials. Despite these advances, applications nanoparticle-based therapeutic/imaging agents remain limited by biological, immunological, translational barriers. In order to overcome existing status quo drug delivery, there is a need open frank discussion nanomedicine community on what needed make qualitative...
The Nanotechnology Characterization Laboratory's (NCL) unique set-up has allowed our lab to handle and test a variety of nanoparticle platforms intended for the delivery cancer therapeutics and/or imaging contrast agents. Over last six years, NCL characterized more than 250 different nanomaterials from 75 investigators. These submitted stem range backgrounds experiences, including government, academia industry. This given valuable opportunity observe trends in safety biocompatibility, as...
Novel physicochemistries of engineered nanomaterials (ENMs) offer considerable commercial potential for new products and processes, but also the possibility unforeseen negative consequences upon ENM release into environment. Investigations ecotoxicity have revealed that unique properties ENMs a lack appropriate test methods can lead to results are inaccurate or not reproducible. The occurrence spurious misinterpretations from toxicity tests investigations (as opposed traditional toxicants)...
In this study, tolerance induction by preexposure of murine macrophages to Toll-like receptor (TLR)2 and TLR4 agonists was revisited, focusing on the major signaling components associated with NF-kappaB activation. Pretreatment a pure agonist (protein-free Escherichia coli (Ec) LPS) or TLR2 (Porphyromonas gingivalis LPS synthetic lipoprotein Pam3Cys) led suppression TNF-alpha secretion, IL-1R-associated kinase-1, IkappaB kinase (IKK) activities, c-jun N-terminal kinase, extracellular...
Blood platelets are essential in maintaining hemostasis. Various materials can activate and cause them to aggregate. Platelet aggregation vitro is often used as a marker for materials' thrombogenic properties, studying nanomaterial interaction with an important step toward understanding their hematocompatibility. Here we report evaluation of 12 formulations PAMAM dendrimers varying size surface charge. Using cell counter based method, light transmission aggregometry scanning electron...