A5058337709- Radiopharmaceutical Chemistry and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Radioactive element chemistry and processing
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Lanthanide and Transition Metal Complexes
- Chemical Synthesis and Characterization
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Boron Compounds in Chemistry
- Organometallic Complex Synthesis and Catalysis
- Neuroendocrine Tumor Research Advances
- Radiation Therapy and Dosimetry
- Nuclear and radioactivity studies
- Radioactive contamination and transfer
- Inorganic Chemistry and Materials
- Prostate Cancer Treatment and Research
- Asymmetric Hydrogenation and Catalysis
- Analytical chemistry methods development
- Graphite, nuclear technology, radiation studies
- Analytical Chemistry and Chromatography
University of Missouri
2016-2025
Forschungszentrum Jülich
2015-2016
Washington State University
2015-2016
Advisory Board Company (United States)
2014
Harry S. Truman Memorial Veterans' Hospital
1998-2009
Illinois Institute of Technology
2006
University of Maryland, Baltimore County
2006
Wayne State University
1999-2000
Bristol-Myers Squibb (United States)
1991-1998
Bracco (United States)
1998
Plants and seeds are the main dietary sources of zinc, iron, manganese, copper, but also entry point for toxic elements such as cadmium into food chain. We report here that an Arabidopsis oligopeptide transporter mutant, opt3-2, over-accumulates (Cd) in roots but, unexpectedly, under-accumulates Cd leaves. The distribution opt3-2 differs from suggesting a metal-specific mechanism metal partitioning within plant. mutant constitutively up-regulates Fe/Zn/Cd IRT1 FRO2 roots, indicative...
The BB2 receptor subtype, of the bombesin family receptors, has been shown to be highly overexpressed in a variety human tumors, including prostate cancer. Bombesin (BBN), 14-amino acid peptide, target with high affinity. 64Cu (half-life = 12.7 h, beta+: 18%, E(beta+ max) 653 keV; beta-: 37%, E(beta- 578 keV) is radioisotope that clinical potential for application both diagnostic imaging and radionuclide therapy. Recently, new chelation systems such as...
Background: As part of our continuing quest to enhance the efficacy bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward use resveratrol for production biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is exploit inherent pro-apoptotic properties (AuNPs) through synergistic anti-tumor characteristics resveratrol, with developing a new class nanotechnology-based phytochemical-embedded AuNPs applications...
Extraction of trace pertechnetate (99mTcO4–) from aqueous media using hydrophobic deep eutectic solvents (DESs) is reported for the first time. The DESs studied comprise a 1:2 molar ratio tetraalkylammonium or tetraalkylphosphonium halide mixed with monocarboxylic acid (i.e., saturated fatty acid). Quantitative (>99%) removal tracer levels 99mTcO4– an phase in presence large excess competing anions (e.g., Cl–, NO3–, HCO3–, H2PO4–, SO42–) within 5–60 min at 25 °C without aid formal extracting...
Abstract The OLIGOPEPTIDE TRANSPORTER 3 (OPT3) has recently been identified as a component of the systemic network mediating iron (Fe) deficiency responses in Arabidopsis. Reduced expression OPT3 induces an over accumulation Fe roots and leaves, due part by elevated IRON‐REGULATED 1. Here we show however, that opt3 leaves display transcriptional program consistent with overload, suggesting excess is properly sensed OPT3‐mediated shoot‐to‐root signaling critical to prevent overload. We also...
α-Melanocyte stimulating hormone (α-MSH) analogs, cyclized through site-specific rhenium (Re) and technetium (Tc) metal coordination, were structurally characterized analyzed for their abilities to bind α-MSH receptors present on melanoma cells in tumor-bearing mice. Results from receptor-binding assays conducted with B16 F1 murine indicated that affinity was reduced approximately 1% of its original levels after Re incorporation into the cyclic Cys 4,10 , d -Phe 7 –α-MSH 4-13 analog....
ADVERTISEMENT RETURN TO ISSUEPREVArticleThe Role of Inorganic Chemistry in the Development Radiometal Agents for Cancer TherapyMary Jane Heeg and Silvia S. JurissonView Author Information Departments Chemistry, Wayne State University, Detroit, Michigan 48202, University Missouri, Columbia, Missouri 65211 Cite this: Acc. Chem. Res. 1999, 32, 12, 1053–1060Publication Date (Web):November 24, 1999Publication History Received13 January 1998Published online24 November 1999Published inissue 1...
Treatment of the chloride bridged species [{M(L)Cl(μ-Cl)}2] (M = Ru, L 4-MeC6H4CHMe2, C6H6, or C6Me6; M Ir, C5Me5) with silver salts AgX (X BF4, CF3SO3, CF3CO2 etc.) followed by reflux bowl-shaped macrocycle cyclotriveratrylene (CTV) results in clean formation mono-, di-, and trimetallic CTV complexes [{M(L)}n(CTV)]X2n (n 1, 2, 3). Further ReO4-, I-) may be generated anion metathesis. All three types complex display novel host−guest properties. In case monometallic hosts disruption...
Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization by edible gum arabic matrix provided an effective pathway toward vivo stable target-specific nanoparticles.
Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation the from its target, chelate design for complexing a biologically stable environment, specific targeting to vivo site, nuclear imaging and/or radiotherapy applications resultant radiopharmaceutical. The critical importance inorganic chemistry application radiometal-containing therapy agents described historical...
Abstract Diagnostic and therapeutic nuclear medicine relies heavily on radiometal nuclides. The most widely used well-known radionuclide is technetium-99m ( 99m Tc), which has dominated diagnostic since the advent of 99 Mo/ Tc generator in 1960s. Since that time, many more radiometals have been developed incorporated into potential radiopharmaceuticals. One critical aspect radiometal-containing radiopharmaceuticals their stability under vivo conditions. chelator coordinated to a key factor...
Abstract The reduction of pertechnetate (TcO 4 − ) with freshly prepared amorphous iron sulfide was investigated. (FeS) shown to have an elemental composition FeS 0.97 for all the size fractions and a point zero charge pH pzc =7.4. Solubility studies in various buffers indicated that range 6.1–9.0, concentrations dissociated Fe 2+ S 2− were negligible. reductive immobilization TcO be accelerated by increasing ionic strength strongly dependent. At values below , positively charged surface...
Rhenium, the third-row congener of technetium, is often used to develop macroscopic chemistry potential 99mTc diagnostic radiopharmaceuticals. The rhenium analogues 99mTc-furifosmin are being developed for radiotherapy multidrug-resistant tumors. Complexes form trans-[MIII(PR3)2(N2O2-Schiff base)]+ interest imaging and treatment Reaction tetradentate Schiff ligand 4,4′-[(1E,1′E)-[ethane-1,2-diylbis(azanylylidene)]bis(methanylylidene)]bis(2,2,5,5-tetramethyl-2,5-dihydrofuran-3-ol) (tmf2enH2)...
Rhenium-cyclized CCMSH analogues are novel melanoma-targeting metallopeptides with high tumor uptake, long retention, and low background in normal tissues, which make these an ideal structural motif for designing agents. ReCCMSH has been derivatized a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelate so that it can be labeled wide variety of radionuclides imaging therapeutic applications. This study involved optimization the vivo biological properties DOTA-ReCCMSH (S),...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew oxotechnetium(V) complexes of N,N'-ethylenebis(acetylacetone imine), N,N'-ethylenebis(salicylideneamine), and o-phenylenebis(salicylideneamine). X-ray structures the imine) N,N'-ethylenebis(salicylideneamine)Silvia Jurisson, Leonard F. Lindoy, Keith P. Dancey, Mary McPartlin, Peter A. Tasker, Daljit K. Uppal, Edward DeutschCite this: Inorg. Chem. 1984, 23, 2, 227–231Publication Date (Print):January 1, 1984Publication History Published online1...