A5050142805- Advanced biosensing and bioanalysis techniques
- Characterization and Applications of Magnetic Nanoparticles
- Magnetic properties of thin films
- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- Health and Medical Research Impacts
- RNA Interference and Gene Delivery
- Pharmaceutical Practices and Patient Outcomes
- Theoretical and Computational Physics
- Health Sciences Research and Education
- Nanoplatforms for cancer theranostics
- Iron oxide chemistry and applications
- Magnetic Properties and Synthesis of Ferrites
- Graphene and Nanomaterials Applications
- Advanced Biosensing Techniques and Applications
- Innovations in Medical Education
- Nanocluster Synthesis and Applications
- 3D Printing in Biomedical Research
- Biotechnology and Related Fields
- Health Policy Implementation Science
- Gold and Silver Nanoparticles Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Computational Drug Discovery Methods
- Anodic Oxide Films and Nanostructures
American Association of Colleges of Pharmacy
2018-2024
Cyrus Biotechnology
2024
Seattle University
2024
National Cancer Institute
2010-2017
National Institutes of Health
2010-2017
Carnegie Mellon University
2000-2011
United States Naval Research Laboratory
2007-2011
Division of Program Coordination Planning and Strategic Initiatives
2011
Science Applications International Corporation (United States)
2010
Scripps Research Institute
2009-2010
Remarkable progress has recently been made in the synthesis and characterization of engineered nanoparticles for imaging treatment cancers, resulting several promising candidates clinical trials. Despite these advances, applications nanoparticle-based therapeutic/imaging agents remain limited by biological, immunological, translational barriers. In order to overcome existing status quo drug delivery, there is a need open frank discussion nanomedicine community on what needed make qualitative...
Fe nanoparticles prepared by iron carbonyl decomposition using different methods are compared structurally, chemically, and magnetically. The specific magnetization of the particles was determined from magnetic moment, particle size observed transmission electron microscopy, total concentration found calibrated X-ray fluorescence. volume fraction oxide is reported for sizes made slightly techniques.
We describe the magnetic properties of gold-coated iron nanoparticles, and effects low pH heat treatment. Acicular spherical based nanoparticles were coated with a thin layer gold. The morphology particles examined using transmission electron microscopy alternative gradient magnetometry. While small had relatively uniform layers coatings, larger acicular many gold clusters decorating surface. original specific moment 145 emu/g coercivity 1664 Oe. Corrosion tests showed good corrosion...
The colloidal stability of gold nanoparticles (AuNPs) cap-exchanged with either monothiol- or dithiolane-terminated PEG-OCH3 ligands was investigated. Three distinct aspects were explored: (1) effects excess salt concentration; (2) ligation competition by dithiothreitol (DTT); and (3) resistance to sodium cyanide digestion. We found that overall presenting higher coordination numbers (dithiolane) exhibit much better added against from DTT compared their monodentate counterparts. Resistance...
Journal Article Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from endolysosomal system Get access James B. Delehanty, Delehanty Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington DC 20375, USA E-mail: James.delehanty@nrl.navy.mil Search other works by this author on: Oxford Academic Google Scholar Christopher E. Bradburne, Bradburne Kelly Boeneman, Boeneman Kimihiro Susumu, Susumu Optical Sciences...
Multicolor fluorescent labeling of both intra- and extracellular structures is a powerful technique for simultaneous monitoring multiple complex biochemical processes. This approach remains extremely challenging, however, as it often necessitates the combinatorial use numerous targeting probes (e.g., antibodies), multistep bioconjugation chemistries, different delivery strategies electroporation or transfection reagents), cellular fixation coupled with membrane permeabilization, spectral...
We characterized the resonance energy transfer interactions for conjugates consisting of QD donors self-assembled with three distinct fluorescent protein acceptors: two monomeric proteins, dsRed derivative mCherry or yellow and multi-chromophore b-phycoerythrin light harvesting complex. Using steady-state time-resolved fluorescence, we showed that nonradiative excitation in these can be described within Förster dipole-dipole formalism, efficiencies vary degree spectral overlap,...
High-frequency hysteresis measurements were performed on two different types of hydrosols iron oxide particles: fully dispersed and highly clustered. The sol showed superparamagnetic behavior across the frequency range investigated, while clustered sample exhibited significant hysteresis. hysteretic losses then directly related to magnetic hyperthermia in a sinusoidal field amplitude 10 mT at 140 kHz, where heated by up 25degC 1000 s similar concentration no measurable heating.
Water solubilized nanoparticles such as CdSe−ZnS core−shell nanocrystals (quantum dots, QDs) have great potential in bioimaging and sensing applications due to their excellent photophysical properties. However, the efficient modification of QDs with complex biomolecules represents a significant challenge. Here, we describe straightforward arylhydrazone approach for chemoselective covalent that is compatible neutral pH micromolar concentrations peptide target. The kinetics can be monitored...
Nanotechnology will have great impact on how cancer is diagnosed and treated in the future. New technologies to detect image cancerous changes materials that enable new methods of treatment radically alter patient outcomes. The National Cancer Institute (NCI) Alliance for sponsors research prevention, diagnosis, therapy promotes translation basic science discoveries into clinical practice. Fourth Annual NCI Principal Investigator Meeting was held Manhattan Beach, California October 20−22,...
Simultaneous detection of multiple independent fluorescent signals or signal multiplexing has the potential to significantly improve bioassay throughput and allow visualization concurrent cellular events. Applications based on multiplexing, however, remain hard achieve in practice due difficulties both implementing hardware photophysical liabilities associated with available organic dye protein fluorophores. Here, we used charge-transfer interactions between luminescent semiconductor quantum...
Nanotechnology-enabled sensors (or nanosensors) will play an important role in enabling the progression toward ubiquitous information systems as Internet of Things (IoT) emerges. Nanosensors offer new, miniaturized solutions physiochemical and biological sensing that enable increased sensitivity, specificity, multiplexing capability, all with compelling economic drivers low cost high-energy efficiency. In United States, Federal agencies participating National Nanotechnology Initiative (NNI)...
The magnetic properties of monodisperse Fe nanoparticles with over 4 orders magnitude difference in concentration are studied by a combination ordinary and remanent hysteresis loops, zero field cooled magnetization as function temperature, relaxation rates. We compare the behavior dilute dispersions different concentrations, dispersions, arrays made from same particles, nanoparticle particle sizes separations. results related to theoretical predictions used create unified picture...
To evaluate persistence of measles antibody after revaccination, levels were measured 6 years revaccination 40 hemagglutination-inhibition (HAI) antibody-negative students who had participated in a serosurvey Massachusetts. Twelve subjects been HAI antibody-positive and not revaccinated included as comparison group. Before 7 revaccinees no detectable plaque reduction neutralization (PRN) (group 1) 33 low PRN 2). Three weeks all group 1 30 (90%) 2 developed fourfold or greater rise antibody....
Chemically stabilized 7.0 nm Fe and 3.9 FePt nanoparticles have been self-assembled into thin arrays, imaged by transmission electron microscopy. The local packing structures stacking sequences of the arrays were uniquely identified a combination bright-field imaging projected potential image simulations. Close-packed structures, hexagonal close-packed (hcp) face-centered cubic (fcc), observed for nanoparticles, while loosely packed body-centered (bcc) structure was detected as well fcc hcp....
There has been significant progress in utilizing nanotechnology several areas of cancer care, including vitro diagnostics, imaging, and therapy. The National Cancer Institute, which currently supports an array research activities nanotechnology, convened a strategic workshop to explore the most promising directions for future resource investment. major discussion points as well opportunities identified are presented herein.
The transverse susceptibility (TS) of arrays self-assembled Fe nanoparticles has been studied using a sensitive radio-frequency resonant technique. Symmetrically located broad peaks in the TS data are observed below blocking temperature as applied field is swept from positive to negative saturation. These occur at effective anisotropy fields $(\ifmmode\pm\else\textpm\fi{}{H}_{K})$ with peak width determined by distribution ${H}_{K}$ nanoparticle array system. features be strongly affected...
A group of 2097 Haitian infants 6 to 11 months age were randomized receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10- 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions noted. effective equivalent doses as measured by the proportion vaccinated children with antibody concentrations greater equal 200 mIU/ml 2 after vaccination and persistence at 18 24 age. High titer administered induced in 83% plaque reduction...
EXECUTIVE SUMMARYThe 2020 Special Committee on Substance Use and Pharmacy Education was charged to update the work of 2010 Abuse Report (SAPER) specifically with recommendations core curricular content delivery processes substance misuse use disorder (SUD). This report provides information committee's process address charges, background resources pertaining rationale for SUD being a critical topic curriculum at colleges schools pharmacy. committee offers several Association Colleges (AACP) charges.
The phase transformation from fcc to L10 in FePt nanoparticles was investigated both thick film samples and self-assembled arrays as a function of the annealing temperature, using transmission electron microscopy, x-ray diffraction, differential scanning calorimetry, magnetometry. A significant fraction surfactant decomposes into gaseous products below 500 °C, removing steric barrier between particle cores. This causes particles coalesce at same temperatures where high anisotropy occurs.