A5081803414- Vaccine Coverage and Hesitancy
- Hearing Impairment and Communication
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Healthcare Policy and Management
- HIV/AIDS Research and Interventions
- Hearing Loss and Rehabilitation
- Adolescent Sexual and Reproductive Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Tuberculosis Research and Epidemiology
- Ear Surgery and Otitis Media
- Trypanosoma species research and implications
- Blood groups and transfusion
- Interpreting and Communication in Healthcare
- Antibiotics Pharmacokinetics and Efficacy
- Adolescent and Pediatric Healthcare
- HIV Research and Treatment
- Family and Disability Support Research
- Airway Management and Intubation Techniques
- Emergency and Acute Care Studies
- Infant Development and Preterm Care
- Calcium signaling and nucleotide metabolism
- Research on Leishmaniasis Studies
University of Auckland
2018-2025
Georgia State University
2016-2017
Johns Hopkins University
1991-2016
University of Colorado Denver
2016
Colorado School of Public Health
2016
Center for Global Health
2016
Denver Health Medical Center
2016
Health and Hospital Corporation
2016
Universidad Francisco Marroquín
2016
GlaxoSmithKline (Brazil)
2016
A core component of delivering care head and neck diseases is an adequate workforce. The World Health Organization report, Multi-Country Assessment National Capacity to Provide Hearing Care, captured primary workforce estimates from 68 member states in 2012, noting that response rates were a limitation updated more comprehensive data are needed.
We enrolled 427 consecutive patients with tuberculosis diagnosed in Cité Soleil, Haiti a trial of short-course intermittent therapy. All received supervised therapy isoniazid, rifampin, pyrazinamide, and ethambutol thrice weekly for 8 wk, followed by isoniazid rifampin 18 wk. At entry, the 177 human immunodeficiency virus (HIV)-infected (42%) were found significantly more likely to have extrapulmonary negative tuberculin skin tests (p < 0.05). Treatment was well tolerated both groups...
Introduction Pacific peoples experience inequity in accessing hearing health care and are disproportionately exposed to the underlying determinants impacting ear Aotearoa New Zealand. Understanding community members’ worldviews, including perspectives, beliefs values, is essential developing appropriate responsive healthcare services meet needs of peoples. Aim The purpose this paper understand knowledge held by regarding Methods A mixed-methods approach was used. Twelve semi-structured...
To determine the community-wide incidence of missed opportunities to vaccinate, describe clinical settings in which they occur, and estimate impact on immunization coverage.We abstracted outpatient medical records from a random, community-based sample 2-year-old children whose residence was inner-city Baltimore. The date each vaccine date, diagnoses, temperature at visit were collected for 502 98 different provider sites.Missed vaccinate up-to-date vaccination status.By 24 months age, 75%...
To evaluate the impact of measles vaccination on survival children residing in a periurban slum Haiti, total-population survey was conducted 2.5 years after completion one-time study serologic response to vaccine administered same population. Pregnancy histories from 16 400 women population revealed that 1499 had been born during 7-month interval would have made them eligible for participation program. Of these children, 1381 (92.1%) survived 9 months age, median age administered....
Objective To determine the effect of moderate dose dexamethasone administered before antibiotics on outcome African children with sepsis. Methods The design was a randomized, double blinded, placebo-controlled trial (0.2 mg/kg) vs. placebo given intravenously antibiotic therapy. Patients were recruited from patient populations at two missionary hospitals. Primary variables determined analysis data. Results Seventy-two sepsis enrolled in study. Treatment not associated improved for any six...
Journal Article Herpes Simplex Virus Type 2 Infection, Syphilis, and Hepatitis B Infection in Haitian Women with Human Immunodeficiency 1 T Lymphotropic I Infections Get access Reginald Boulos, Boulos Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrea J. Ruff, Ruff André Nahmias, Nahmias Elizabeth Holt, Holt Lee Harrison, Harrison Larry Magder, Magder Stefan Z. Wiktor, Wiktor Thomas C. Quinn, Quinn Harold Margolis, Margolis Neal A. Halsey Reprints or...
A group of 2097 Haitian infants 6 to 11 months age were randomized receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10- 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions noted. effective equivalent doses as measured by the proportion vaccinated children with antibody concentrations greater equal 200 mIU/ml 2 after vaccination and persistence at 18 24 age. High titer administered induced in 83% plaque reduction...
The World Health Organization (WHO) estimates that 466 million people globally have significant hearing loss, a figure set to double by 2050. 1 Ear disease, such as otitis media, and loss can consequences on individuals, affecting communication, language development, educational opportunities employment choices, may also contribute social isolation, cognitive decline depression. 1,2The 2017 Assembly resolution Prevention of deafness recognizes ear disease are important public health issues....
Hearing and vestibular research in Aotearoa New Zealand (NZ) spans basic sciences, clinical research, public health. Equitable health care sustainable models are threatened by several factors including the increasing prevalence of hearing impairment disorders, reforms to NZ system, funding challenges within environment. Our perspectives as early career researchers can shape future healthcare, practice NZ.
Introduction Traditionally, grommet post-surgical follow-up care has been undertaken by otorhinolaryngologists (ORLs), but in a large public outpatient ORL service Auckland, New Zealand (Counties Manukau), this responsibility partially devolved to general practitioners (GPs). Aim The purpose of study is explore the perspectives and experiences families/whānau GPs regarding services for children. Methods A mixed methods approach was used with family/whānau comprising semi-structured...
A rapid ethnographic assessment of barriers to health service utilization was conducted identify maternal factors predicting use child immunizations in Haiti. Methods included four focus group interviews, natural individual interviews with 14 care providers and participant observation at vaccination posts. Analysis qualitative data identified five categories associated immunization use: competing priorities, low motivation, socioeconomic constraints, perceived accessibility services, fears...
ABSTRACT Therapies for human African trypanosomiasis and Chagas disease, caused by Trypanosoma brucei cruzi , respectively, are limited, providing minimal therapeutic options the millions of individuals living in very poor communities. Here effects 10 novel quinolines evaluated silico phenotypic studies using vitro vivo models. Absorption, distribution, metabolism, excretion, toxicity (ADMET) properties revealed that most molecules did not infringe on Lipinski's rules, which is a prediction...
Reliable and comprehensive data on disease levels, patterns, trends in populations are required to monitor global local epidemics assess the effectiveness of public health approaches injury prevention control. For most developing countries, little is reliably known about causes mortality or incidence, prevalence, duration. Advances technology offer opportunity collect biomarkers—biological clinical data—in existing large‐scale, national sample surveys. Such biomarkers could result...
Much of the research on determinants health service utilization has focused economic and cognitive variables which influence preventative behavior. Our ethnographic study maternal perceptions barriers incentives to immunization use in Haiti underscores importance 'hidden' social psychological costs utilization, such as embarrassment, fear, child care difficulties, competing demands time. Findings from focus group interviews with mothers, individual providers, observation at posts identified...
Objectives. This study sought to identify provider practices and policies in private pediatric settings that relate vaccination status, controlling for the characteristics of children served. Methods. Vaccination data came from medical records 709 randomly selected 2-year-old at 18 managed care organizations Maryland, family 466 telephone interviews with children's parents, site questionnaires 42 individual physician nurse practitioner questionnaires. Logistic regression generalized...
Fluoroquinolone (FQ) exposure before tuberculosis (TB) diagnosis is common, but its effect on outcomes, including mortality, unclear.Among TB patients reported to the Tennessee Department of Health from 2007 2009, we assessed FQ within 6 months diagnosis. The primary outcome was combined endpoint death at time and during anti-tuberculosis treatment.Among 609 cases, 214 (35%) received FQs A total 71 (12%) persons died; 10 (2%) were dead 61 (10%) died treatment. In multivariable logistic...
Arylimidamide (AIA) compounds containing two pyridylimidamide terminal groups (bis-AIAs) possess outstanding in vitro antileishmanial activity, and the frontrunner bis-AIA DB766 (2,5-bis[2-(2-isopropoxy)-4-(2-pyridylimino)aminophenyl]furan) is active visceral leishmaniasis models when given orally. Eighteen a single group (mono-AIAs) were synthesized evaluated for their potential. Six of these exhibited sub-micromolar potency against both intracellular Leishmania donovani amazonensis...
Maternal-infant transmission of HIV-1 occurs in 13-40% pregnancies. Studies on maternal immunity to HIV antigens have used from viruses not representative clinical isolates and been conflicting. Using a consensus peptide sequence based found Haiti, we that Haitian mothers who transmitted infection their offspring had significantly higher mean concentrations IgG1 antibodies the V3 loop primary neutralising domain viral envelope (gp 160) than non-transmitters (p = 0.02). Concentrations IgA...