A5018847170- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Sex work and related issues
- Pneumocystis jirovecii pneumonia detection and treatment
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- LGBTQ Health, Identity, and Policy
- Hepatitis C virus research
- Reproductive tract infections research
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- HIV/AIDS Impact and Responses
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Lymphoma Diagnosis and Treatment
- Syphilis Diagnosis and Treatment
- Bone and Joint Diseases
- Cytomegalovirus and herpesvirus research
- Migration, Health and Trauma
- Healthcare Policy and Management
Rutgers, The State University of New Jersey
2015-2024
Rutgers Sexual and Reproductive Health and Rights
2000-2023
Columbia University
1996-2023
Albert Einstein College of Medicine
2008-2021
Rwanda Military Hospital
2020-2021
University of Rwanda
2021
Creative Commons
2021
New York Medical College
2020
Republic of Burundi
2020
SUNY Downstate Health Sciences University
2016
We determined incidence and future projections of dementia after AIDS onset in 492 homosexual men with the Baltimore/Los Angeles sites Multicenter Cohort Study, 64 whom developed dementia. studied various risk factors for dementia, including demographic clinical features, medical history, markers immune status before AIDS, zidovudine use. During first 2 years HIV at an annual rate 7%. Overall, 15% cohort followed through death The median survival was 6.0 months. Using a proportional hazards...
This paper considers nonparametric estimation in a varying coefficient model with repeated measurements (Yij, Xij, tij), for i = 1,…, ni and j ni, where Xij=(Xijo,…, xijk)T tij) denote the jth outcome, covariate time design points, respectively, of ith subject. The considered here is Yij XijTβ(tij) + +i(tij), β(t) (β0(t), …, Bk(t))T, k ≧ 0, are smooth functions interest εi(t) zero-mean stochastic process. assumed to be independent different subjects but can correlated at points within each...
Background: Cross-sectional studies suggest an association between bacterial vaginosis (BV) and HIV-1 infection. However, assessment of a temporal effect was not possible. Objectives: To determine the BV other disturbances vaginal flora with HIV seroconversion among pregnant postnatal women in Malawi, Africa. Design: Longitudinal follow-up postpartum women. Methods: Women attending their first antenatal care visit were screened for after counselling obtaining informed consent....
If Kaposi's sarcoma–associated herpesvirus (KSHV) is the cause of sarcoma, serologic evidence infection should be present in patients before disease develops.
Studies show that around 10-40% HIV-positive women will give birth to children who are also infected. However, the risk factors for transmission from mother child not well understood and effects of maternal nutritional status unknown. We conducted a study vitamin A in pregnant as factor mother-to-child HIV Malawi. Serum A, height, weight, CD4 T-cell counts, duration breastfeeding were measured 338 mothers whose infant's serostatus was known. Mother-to-child 21.9% among infants survived 12...
Among patients infected with human immunodeficiency virus type 1 (HIV-1), early and widespread use of prophylactic regimens against Pneumocystis carinii is changing the pattern illnesses related to acquired syndrome (AIDS).
Effective strategies are urgently needed to reduce mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) through breast-feeding in resource-limited settings.Women with HIV-1 infection who were infants enrolled a randomized, phase 3 trial Blantyre, Malawi. At birth, the randomly assigned one three regimens: single-dose nevirapine plus week zidovudine (control regimen) or control regimen daily extended prophylaxis either (extended nevirapine) dual prophylaxis) until age...
Human immunodeficiency virus (HIV) type 1 load in breast milk and mastitis were examined as risk factors for vertical transmission of HIV-1. Six weeks after delivery, HIV-1 sodium (an indicator mastitis) measured from 334 HIV-1—infected women Malawi. Median was 700 copies/mL among with infants versus undetectable (<200 copies/mL) those uninfected infants, respectively (P < .0001). Elevated levels consistent occurred 16.4% associated increased 920 without elevated levels, Mastitis may...
In Thailand the epidemic of human immunodeficiency virus (HIV) infection is recent origin. Because high seroprevalence HIV among sex workers, Ministry Public Health began a program in 1990 and 1991 to promote use condoms during commercial sex. We evaluated effect this other programs prevent Thailand.
It is unclear whether there are differences between men and women with human immunodeficiency virus type 1 (HIV-1) infection in the plasma level of viral RNA (the load). In men, initial load after seroconversion predicts likelihood progression to acquired syndrome (AIDS), but relation two has not been assessed women. Currently, guidelines for initiating antiretroviral therapy applied uniformly men.
Objectives: Kaposi's sarcoma-associated herpesvirus (KSHV), a newly discovered human gammaherpesvirus, is found in the majority of KS lesions from patients with and without AIDS. Peripheral blood mononuclear cells (PBMC) were examined for KSHV DNA to determine whether viral infection precedes onset this neoplasm. Design: Randomized blinded case–control study prospectively collected PBMC samples ongoing cohort studies. Methods: Paired drawn before after 21 AIDS-KS compared paired 23 high-risk...
Objective. To compare medical expenditures for the elderly (65 years old) over last year of life with those nonterminal years. Data Source. From 1992–1996 Medicare Current Beneficiary Survey (MCBS) data from about ten thousand persons each year. Study Design. Medical and by source payment type care were estimated using robust covariance linear model approaches applied to MCBS data. Collection. The is a panel survey complex weighted multilevel random sample beneficiaries. A structured...
Abstract We consider the estimation of k + 1-dimensional nonparametric component β(t) varying-coefficient model Y(t) = X T (t)β(t) ε(t) based on longitudinal observations (Yij , i (tij ), tij 1, …, n, j ni where is jth observed design time point t ith subject and Yij ) are real-valued outcome R k+1 valued covariate vectors at tij. The subjects independently selected, but repeated measurements within possibly correlated. Asymptotic distributions established for a kernel estimate that...
Abstract Obesity is a major risk factor for endometrial cancer, relationship thought to be largely explained by the prevalence of high estrogen levels in obese women. also associated with insulin, known mitogen. However, no prospective studies have directly assessed whether insulin and/or insulin-like growth factor-I (IGF-I), related hormone, are cancer while accounting levels. We therefore conducted case-cohort study incident Women's Health Initiative Observational Study, cohort 93,676...
Objectives: To examine rates of HIV-1 and sexually transmitted disease (STD) among pregnant postpartum women in urban Malawi, Africa. Design: Serial cross-sectional surveys a prospective study. Methods: Three major were conducted 1990, 1993 1994/1995. Consecutive first-visit antenatal giving birth at the Queen Elizabeth Central Hospital tested for HIV STD after counseling obtaining informed consent. Unlinked, anonymous testing was also on smaller samples same hospital to provide annual...
To assess the effect of human immunodeficiency virus (HIV) immunosuppression on ongoing hepatitis C (HCV) infection, CD4 lymphocyte counts and serum concentrations HCV RNA, HIV alanine aminotransferase (ALT) were evaluated among members a cohort injecting drug users (IDUs). With 100 participants randomly selected at various stages HIVrelated immunosuppression, HeV RNA increased with age (P = .007) higher in HIV-positive IDUs 201-500 .026) 51-200 .004) cells/mL than HIV-negative participants....
The authors sought to determine whether rates of depressive symptoms change from early- late-stage HIV-1 infection and the predictors as AIDS develops.The data for this study were 911 HIV-seropositive men-community volunteers four U.S. cities-who entered 10-year Multicenter Cohort Study without a diagnosis subsequently developed AIDS. subjects underwent semiannual follow-ups during period. outcome measures-overall symptoms, nonsomatic syndromal depression, severe depression-were assessed...
Context.—Plasma human immunodeficiency virus type 1 (HIV-1) viral load and CD4+ cell count are used to predict prognosis of persons infected with HIV. However, whether combining these markers improves prognostic accuracy they for injection drug users (IDUs) nonwhite HIV has not been extensively investigated.Objective.—To evaluate plasma as indicators the acquired syndrome (AIDS) infectious disease deaths.Design.—Cohort study initiated in 1988 1989 follow-up up 7.9...
Abstract Obesity is a risk factor for colorectal cancer, and hyperinsulinemia, common condition in obese patients, may underlie this relationship. Insulin, addition to its metabolic effects, has promitotic antiapoptotic activity that be tumorigenic. Insulin-like growth (IGF)-I, related hormone, shares sequence homology with insulin, even stronger mitogenic effects. However, few prospective cancer studies directly measured fasting none evaluated free IGF-I, or endogenous estradiol, potential...
<h3>Objective:</h3> To estimate the incidence and prevalence of cytomegalovirus retinitis (CMV-R) in late-stage human immunodeficiency virus type 1 disease. <h3>Design:</h3> Cohort study. <h3>Setting:</h3> The Multicenter AIDS Study, an ongoing 10-year study 1-infected homosexual men with semiannual visits CD4+ cell testing. <h3>Study Participants:</h3> Three hundred sixty-seven from Study who were receiving zidovudine and<i>Pneumocystis carinii</i>prophylaxis had counts fall below...