A5074071367- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Endoplasmic Reticulum Stress and Disease
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Artificial Intelligence in Healthcare and Education
- Genetic Syndromes and Imprinting
- Reproductive System and Pregnancy
University of Hawaiʻi at Mānoa
2016-2025
University of Hawaii System
2016-2025
Cancer Center of Hawaii
2016-2025
University of Hawaii Cancer Center
2016-2025
Qingdao University
2024-2025
University of Florida
2024-2025
Affiliated Hospital of Qingdao University
2024-2025
Jiujiang First People's Hospital
2025
Yale University
2008-2024
Cancer Genetics (United States)
2015-2023
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that cytosolic lncRNA P53RRA is downregulated cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH Cfp1 silenced or increased expression, respectively. bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 871 RRM interaction domain G3BP1...
Abstract Purpose: Early detection would significantly decrease the mortality rate of ovarian cancer. In this study, we characterize and validate combination six serum biomarkers that discriminate between disease-free cancer patients with high efficiency. Experimental Design: We analyzed 362 healthy controls 156 newly diagnosed patients. Concentrations leptin, prolactin, osteopontin, insulin-like growth factor II, macrophage inhibitory factor, CA-125 were determined using a multiplex,...
High insulin and insulin-like growth factor-I (IGF-I) levels may be associated with an increased breast cancer risk and/or death. Given the need to identify modifiable factors that decrease insulin, IGF-I, death, we investigated effects of a 6-month randomized controlled aerobic exercise intervention versus usual care on fasting its binding protein (IGFBP-3) in postmenopausal survivors.Seventy-five survivors were identified from Yale-New Haven Hospital Tumor Registry randomly assigned (n =...
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
d-limonene is a plant extract with widespread application, and it has been recently reported to have antiproliferative proapoptotic effects on cancer cells. However, the mechanisms by which achieves these effects, especially in lung cancer, are not entirely clear. Therefore, goal of this study was examine explore its action.We examined therapeutic cells xenograft animal model characterizing pathways apoptosis autophagy. Cell proliferation measured using Counting Kit-8, determined flow...
Purpose Primary care physicians are an important source of information on weight management. Nevertheless, loss counseling by these remains inadequate. This study sought to determine physicians' barriers providing in a public hospital, patients' recall recommendations, and the influence understanding, motivation, behavior regarding loss. Method In 2001, four focus groups faculty residents were held at two primary clinics affiliated with Louisiana State University Health Sciences...
MicroRNAs (miRNA) are endogenous noncoding small RNAs that regulate the activity of mRNAs. Many miRNA genes, including let-7a-3, located in CpG islands, suggesting possible epigenetic regulation their expression. Promoter island methylation tumor suppressor genes is involved cancer development and progression. Using real-time methylation-specific PCR reverse transcription-PCR, we analyzed DNA let-7a-3 gene expression let-7a 214 patients with epithelial ovarian to assess effect on expressions...
Abstract Obesity is a major risk factor for endometrial cancer, relationship thought to be largely explained by the prevalence of high estrogen levels in obese women. also associated with insulin, known mitogen. However, no prospective studies have directly assessed whether insulin and/or insulin-like growth factor-I (IGF-I), related hormone, are cancer while accounting levels. We therefore conducted case-cohort study incident Women's Health Initiative Observational Study, cohort 93,676...
Abstract Obesity is a risk factor for colorectal cancer, and hyperinsulinemia, common condition in obese patients, may underlie this relationship. Insulin, addition to its metabolic effects, has promitotic antiapoptotic activity that be tumorigenic. Insulin-like growth (IGF)-I, related hormone, shares sequence homology with insulin, even stronger mitogenic effects. However, few prospective cancer studies directly measured fasting none evaluated free IGF-I, or endogenous estradiol, potential...
Given the negative effects of a breast cancer diagnosis and its treatments on body weight bone mass, we investigated 6-month randomized controlled aerobic exercise intervention vs. usual care composition in survivors. Secondary aims were to examine stratified by important prognostic physiologic variables. Seventy-five physically inactive postmenopausal survivors recruited through Yale-New Haven Hospital Tumor Registry randomly assigned an (n = 37) or 38) group. The group participated 150...
Abstract Objective : To determine the effect of exercise on quality life in (a) a randomized controlled trial among recently diagnosed breast cancer survivors undergoing adjuvant therapy and (b) similar post‐treatment survivors. Methods Fifty newly were recruited through hospital‐based tumor registry to 6‐month, home‐based program ( n =25) or usual care group =25). In separate trial, 75 supervised intervention =37) =38). Participants both studies completed measures happiness, depressive...
Carriage of a non–O ABO blood group and colonization by Helicobacter pylori are thought to be risk factors for pancreatic cancer. We examined these associations in population-based case–control study 373 case patients 690 control subjects frequency matched on sex age. Control were selected random-digit dialing. Seropositivity H its virulence protein CagA was determined enzyme-linked immunosorbent assay (ELISA). Increased cancer associated with (adjusted odds ratio [OR] = 1.37, 95% confidence...
// Ben Liu 1, * , Jinli Qu Fangxiu Xu 1 Yan Guo Yu Wang Herbert 2 Biyun Qian 3 Department of Epidemiology and Biostatistics, Key Laboratory Breast Cancer Prevention Therapy, Ministry Education, Tianjin, National Clinical Research Center Cancer, Tianjin Medical University Institute Hospital, 300060, China Program, Hawaii Center, Honolulu, HI 96813, USA Hongqiao International Medicine, Shanghai Tongren Hospital Faculty Public Health, Jiao Tong School 200025, These authors have contributed...