A5101777805- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- T-cell and B-cell Immunology
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- interferon and immune responses
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Hippo pathway signaling and YAP/TAZ
Nanjing University
2023-2025
Suzhou Municipal Hospital
2023-2025
Zhejiang Chinese Medical University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Nanjing General Hospital of Nanjing Military Command
2024
Guangxi University
2024
Soochow University
2023
Central South University
2013-2023
Second Xiangya Hospital of Central South University
2014-2022
University of Hawaii Cancer Center
2015-2021
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that cytosolic lncRNA P53RRA is downregulated cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH Cfp1 silenced or increased expression, respectively. bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 871 RRM interaction domain G3BP1...
Osteoblastic bone formation and osteoclastic resorption dynamically maintain the homeostasis; in present study, we attempt to investigate mechanism of excessive activation osteoclasts inducing deregulation homeostasis from perspective non-coding RNA regulation. Differentially expressed patterns circRNAs were examined non-treated RANKL + CSF1-treated marrow monocyte/macrophage (BMM) cells differentially-expressed miRNAs during osteoclast differentiation analyzed identified. We found that...
E-cadherins play an essential role in maintaining epithelial polarity by forming Ca2+-dependent adherens junctions between cells. Here, we report that Ca2+ depletion induces E-cadherin ubiquitination and lysosomal degradation Cdc42 plays important regulating this process. We demonstrate activation of Cdc42. This turn up-regulates epidermal growth factor receptor (EGFR) signaling to mediate Src activation, leading degradation. Silencing blocks EGFR induced depletion, resulting a reduction The...
To investigate the biologic relevance and clinical implication of genes involved in multiple gene expression signatures for breast cancer prognosis, we identified 16 published signatures, selected two genes, MAD2L1 BUB1. These appeared 5 were cell-cycle regulation. We analyzed these relation to tumor features disease outcomes. In vitro experiments also performed cell lines, MDA-MB-231 MDA-MB-468, assess proliferation, migration invasion after knocking down genes. High was found be associated...
In recent years, there has been a rapid increase in the prevalence of benign and malignant tumours thyroid gland worldwide, positioning it as one most prevalent neoplasms within endocrine system. While pathogenesis is still unclear, an increasing number studies have found that certain lifestyle residence environments are associated with their occurrence development. This article endeavours to elucidate correlation between lifestyle, residential environment, increased cancer years. It...
Overexpression of epidermal growth factor receptor (EGFR) contributes to increased cell proliferation and migration in breast cancer. However, mechanisms EGFR overexpression remain elusive often cannot be attributed gene amplification. In NIH3T3 fibroblasts, active Cdc42 inhibits c-Cbl-regulated degradation induce cellular transformation. Here, we use two EGFR-overexpressing cancer lines, MDA-MB-231 BT20, as models test the hypothesis that up-regulated activity impairs c-Cbl-mediated...
This study aimed to explore the metabolic changes during neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC) by serum metabolomics analysis, and provide new biomarkers for individualized treatment efficacy prediction. Serum samples from 20 LARC before, after NCRT were collected metabolomic analysis. The metabolites analyzed qualitatively quantitatively using gas chromatography-mass spectrometry (GC-MS). Meanwhile, differences profiles at different time...
Long intergenic noncoding RNAs (lincRNAs) are a relatively new class of non-coding that have the potential as cancer biomarkers. To seek panel lincRNAs pan-cancer biomarkers, we analyzed transcriptomes from over 3300 samples with clinical information. Compared to mRNA, exhibit significantly higher tissue specificities then diminished in tissues. Moreover, lincRNA clustering results accurately classify tumor subtypes. Using RNA-Seq data thousands paired and adjacent normal The Cancer Genome...
MicroRNAs (miRNAs) are an evolutionarily conserved class of small regulatory noncoding RNAs, binding to complementary target mRNAs and resulting in mRNA translational inhibition or degradation, they play important role regulating many aspects physiologic pathologic processes mammalian cells. Thus, efficient manipulations miRNA functions may be exploited as promising therapeutics for human diseases. Two commonly used strategies inhibit include direct transfection chemically synthesized...
Abstract In vivo Ig responses to soluble, haptenated polysaccharide (PS) Ags are T cell independent and do not require CD40 ligand (CD40L). However, little is known regarding the regulation of in PS-specific intact bacteria. We immunized mice with a nonencapsulated, type 2 Streptococcus pneumoniae (R36A) compared parameters that regulated isotype bacterial wall C-PS determinant, phosphorylcholine (PC), relative protein, pneumococcal surface protein A. Consistent previous reports using...
Because HER-2 has been demonstrated in the nuclei of cancer cells, we hypothesized that it might interact with transcription factors activate ERBB2 transcription. Macrohistone 2A1 (H2AFY; mH2A1) was found to cells overexpress HER-2. Of two human mH2A1 isoforms, mH2A1.2, but not mH2A1.1, interacted cell lines. Overexpression significantly increased expression and tumorigenicity. Inhibition kinase activity diminished mH2A1.2-induced cells. Chromatin immunoprecipitation mH2A1.2 stably...
Despite heightened risk of cardiotoxicity associated with combination therapy anthracyclines and trastuzumab in HER2-positive breast cancer patients, little research effort has been invested exploring the molecular mechanisms induced by this therapy. In study, we demonstrate that downregulates both gene protein expressions type IIB DNA topoisomerase/DNA topoisomerase (TOP2B), a major intracellular target mediating doxorubicin-induced cardiotoxicity, human primary cardiomyocytes. This turn...