A5101577217- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Circular RNAs in diseases
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Energy and Environment Impacts
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
Harbin Institute of Technology
2025
Third Xiangya Hospital
2021-2024
Central South University
2021-2024
First Affiliated Hospital of Zhengzhou University
2021-2022
First Affiliated Hospital of Xi'an Jiaotong University
2017-2022
Peking Union Medical College Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2022
Fujian Provincial Cancer Hospital
2022
Background/Aims: Ecological studies have shown that air pollution and prevalence of cigarette smoking are positively correlated. Evidence also suggests a synergistic effect PM2.5 exposure (Environmental Particulate Matter ≤ 2.5 µm in diameter) on lung cancer risk. We aimed to evaluate the interaction between relation mortality determine its underlying mechanisms vitro. Methods: “MOVER” method was used analyze mortality. Cell autophagy malignant behaviors induced by smoke extract (CSE) were...
Background Digestive system cancers are among the most common malignancies, exhibiting consistently high incidence and mortality rates, yet effective detection treatment targets remain limited. Integrin αv (ITGAV, CD51) is a significant member of integrin family, widely recognized for its role in mediating interactions between cells extracellular matrix, as well intracellular signaling. In recent years, ITGAV has been found to have significantly elevated expression multiple tumors, such...
Long non-coding RNAs (lncRNAs) are involved in numerous biological processes lung cancer cells. In our previous studies, we identified a lncRNA, ENST00000439577, which is highly expressed carcinomas, and termed it progression-associated transcript 1 (LCPAT1). To characterize the role of LCPAT1 cancer, conducted current study.Expression autophagy-associated markers tumor tissues cell lines was determined by real-time quantitative polymerase chain reaction (qPCR). Hematoxylin eosin (HE)...
Aim: The goal of this study is to identify differentially methylated (DM) loci associated with long noncoding RNA (lncRNA)/mRNA expression in non-small-cell lung cancer (NSCLC). Materials & methods: Microarrays were used interrogate genome-wide methylation and lncRNA/mRNA NSCLC. Results: We identified 113,644 DM between tumors adjacent tissues. Among them, 26,310 1685 expressed genes, 839 genes had significant correlations expression, which 26 hypermethylated transcription start site 200...
Pancreatic cancer consists one of tumors with the highest degree malignancy and worst prognosis. To date, immunotherapy has become an effective means to improve prognosis patients pancreatic cancer. Long non-coding RNAs (lncRNAs) have also been associated immune response. However, role immune-related lncRNAs in response remains unclear. In this study, we identified lncRNA pairs through a new combinatorial algorithm, then clustered deeply analyzed characteristics functional differences...
Long non-coding RNAs (lncRNAs), a newly identified class of RNA (ncRNA), are defined as molecules at least 200 nucleotides in length that not translated into proteins. LncRNAs contribute to wide range biological processes and master regulators disease occurrence, development, response therapy human malignancies. The lncRNA prostate cancer‑associated transcript 6 (PCAT6) is upregulated various malignancies, including lung cancer, hepatocellular carcinoma, cervical osteosarcoma, glioblastoma,...
The role of NR2F1-AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Therefore, we aimed to investigate the biological mechanism PDAC. expression was measured by using microarray data and real-time PCR. effects knockdown on proliferation, cell cycle progression, invasion vitro tumorigenesis vivo were investigated. competitive endogenous RNAs determined from bioinformatics analyses validated a dual-luciferase reporter gene assay. Potential target mRNAs TargetScan 7.2 selected for...
Pancreatic cancer (PC) is one of the most lethal malignancies, mortality and morbidity which have been increasing over past decade. Ferroptosis, a newly identified iron-dependent cell death pattern, can be induced by iron chelators small lipophilic antioxidants. Nonetheless, prognostic significance ferroptosis-related lncRNAs in PC remains to clarified. We obtained lncRNA expression matrix clinicopathological information patients from The Cancer Genome Atlas (TCGA) International Consortium...
Small nucleolar RNA host genes (SNHGs) as a subset of long noncoding RNAs (lncRNAs) have critical roles in the pathogenesis multiple malignancies, however, role and molecular mechanisms lncRNA SNHG8 osteosarcoma (OS) remain unclear. In present study, correlation or miR-542-3p with clinicopathological elements prognosis OS patents was estimated by TCGA cohort. Cell viability invasion were assessed MTT Transwell assays. The interplay between affirmed luciferase report assay. effects on...
The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been widely concerned as a therapy because of its ability selective triggering cancer cell apoptosis; nevertheless, hepatocellular carcinoma (HCC) exhibits acquired resistance to TRAIL-induced apoptosis. In the present study, tumor-suppressive lncRNA susceptibility candidate 2 (CASC2) was downregulated in HCC tissues and lines; patients with lower CASC2 expression predicted shorter overall survival rate....
Lower-grade gliomas (LGGs) are characterized by remarkable genetic heterogeneity and different clinical outcomes. Classification of LGGs is improved the development molecular stratification markers including IDH mutation 1p/19q chromosomal integrity, which used as a hallmark survival therapy sensitivity LGG patients. However, reproducibility current classification remain ambiguous. This study aimed to construct more accurate risk-stratification approaches.According bioinformatics, sequencing...
To compare the efficacy and safety of high-intensity focused ultrasound (HIFU) radical surgery for non-metastatic pancreatic cancer (PC).
Temozolomide (TMZ) is the major chemotherapy agent in glioma, and isocitrate dehydrogenase (IDH) a well-known prognostic marker glioma. O6-methylguanine-DNA methyltransferase promoter methylation (MGMTmethyl) predictive biomarker overall gliomas rather than IDH mutant gliomas. To discover effective biomarkers that could predict TMZ efficacy low-grade (LGGs), we retrieved data of LGGs from arm EORTC22033-26033 trial as training-set (n = 83), analyzed correlations between long non-coding RNAs...