A5100327929- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Glycation End Products research
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Single-cell and spatial transcriptomics
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biochemical Analysis and Sensing Techniques
Shandong Tumor Hospital
2016-2025
Shandong First Medical University
2016-2025
Harbin Institute of Technology
2025
Sun Yat-sen University
2024-2025
Sun Yat-sen University Cancer Center
2024-2025
Wuxi No.2 People's Hospital
2021-2025
Jiangnan University
2025
Fudan University Shanghai Cancer Center
2021-2024
Japanese Foundation For Cancer Research
2024
The Cancer Institute Hospital
2024
Abstract T-cell receptor (TCR)–based biomarkers might predict patient response to immune checkpoint blockade (ICB) but need further exploration and validation for that use. We sequenced complementarity-determining region 3 of TCRβ chains isolated from PD-1+ CD8+ T cells investigate its value predicting the anti–programmed cell death 1 (PD-1)/PD-ligand (PD-L1) therapy in patients with non–small lung cancer (NSCLC). Two independent cohorts (cohort A, n = 25; cohort B, 15) were used as...
The co-inhibitory receptor Programmed Death-1 (PD-1) curtails immune responses and prevent autoimmunity, however, tumors exploit this pathway to escape from destruction. co-stimulatory OX40 is upregulated on T cells following activation increases their clonal expansion, survival cytokine production when engaged. Although antagonistic anti-PD-1 or agonistic anti-OX40 antibodies can promote the rejection of several murine tumors, some poorly immunogenic were refractory treatment. In present...
It is generally accepted that colorectal cancer (CRC) originates from stem cells (CSCs), which are responsible for CRC progression, metastasis and therapy resistance. The high heterogeneity of CSCs has precluded clinical application CSC-targeting therapy. Here, we aimed to characterize the stemness landscapes screen certain patients more responsive immunotherapy.Twenty-six cell gene sets were acquired StemChecker database. Consensus clustering algorithm was applied subtypes identification on...
Abstract Prostate cancer (PCa) is an extensive heterogeneous disease with a complex cellular ecosystem in the tumor microenvironment (TME). However, manner which heterogeneity shaped by tumors and stromal cells, or vice versa, remains poorly understood. In this study, single‐cell RNA sequencing, spatial transcriptomics, bulk ATAC‐sequence are integrated from series of patients PCa healthy controls. A stemness subset club cells marked SOX9 high AR low expression identified, markedly enriched...
OBJECTIVE Large numbers of people with type 2 diabetes are obese. However, changes in cognition and related brain function obese have not been characterized. Here, we investigated cognition, olfactory function, odor-induced alterations these patients therapeutic effects glucagon-like peptide 1 receptor agonists (GLP-1Ras) on their psychological behavior networks. RESEARCH DESIGN AND METHODS Cognitive, olfactory, activation assessments were administered to 35 nonobese control subjects matched...
The clinical success of the immune checkpoint inhibitor (ICI) targeting programmed cell death protein 1 (PD-1) has revolutionized cancer treatment. However, full potential PD-1 blockade therapy remains unrealized, as response rates are still low across many types. Interleukin-2 (IL-2)-based immunotherapies hold promise, they can stimulate robust T expansion and enhance effector function - activities that could synergize potently with blockade. Yet, IL-2 therapies also carry a significant...
Background The survival benefits of combining chemotherapy (at the maximum tolerated dose, MTD) with concurrent immunotherapy, collectively referred to as chemoimmunotherapy, for treatment squamous cell lung carcinoma (SQCLC) have been confirmed in recent clinical trials. Nevertheless, optimization chemoimmunotherapy order enhance efficacy immune checkpoint inhibitors (ICIs) SQCLC remains be explored. Methods Cell lines, syngeneic immunocompetent mouse models, and patients’ peripheral blood...
Peritumoral hepatocytes are critical components of the liver cancer microenvironment, However, role peritumoral in local tumor immune interface and underlying molecular mechanisms have not been elucidated. YTHDF2, an RNA N
Abstract Evasion of programmed cell death represents a critical form oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning survival despite oncogenic stress could provide basis for potential therapeutic interventions. Here we explore role pro-survival genes integrity during clonal evolution non-small lung (NSCLC). We identify gains MCL-1 at high frequency multiple independent NSCLC cohorts, occurring both clonally and subclonally. Clonal loss functional TP53...
The universally poor clinical outcome makes gastric cancer (GC) still a significant public health threat, the main goal of our research is to develop prognostic signature that can forecast outcomes and immunological characteristics GC via integrating single-cell bulk RNA-sequencing. CD8+ T cell feature genes were screened out by exploring RNA-sequencing (scRNA-seq) profiles retrieved from TISCH2 database. Then, Cox LASSO regressions exploited for constructing model in TCGA cohort based on...
The role of immunotherapy in combination with traditional treatment regime improving the survival cancer patients has attracted more and attention. Especially abscopal effect that describes phenomenon localized radiotherapy leading to regression distant unirradiated tumors enhanced radiotherapy-induced immunogenic cell death activation immune system have become a focus studies. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known powerful stimulator generation, migration...
// Feifei Teng 1 , Xiangjiao Meng Xin Wang Jupeng Yuan 3 Sujing Liu Dianbin Mu 2 Hui Zhu Li Kong Jinming Yu Department of Radiation Oncology, Shandong Cancer Hospital and Institute, University, Jinan, China Pathology, Provincial Key Laboratory Correspondence to: Yu, email: sdyujinming@163.com Kong, kongli7@sina.com Keywords: non-small cell lung cancer, TILs, PD-L1, Foxp3, adjuvant chemotherapy Received: May 20, 2016 Accepted: August 13, Published: September 01, ABSTRACT Purpose: Currently,...
<h3>Background</h3> The iMATRIX-atezolizumab study was a phase I/II, multicenter, open-label designed to assess the safety and pharmacokinetics of atezolizumab in pediatric young adult patients. We describe (PK), exposure-safety, immunogenicity adults with metastatic solid tumors or hematologic malignancies enrolled this study. <h3>Methods</h3> Patients aged < 18 years (<i>n</i> = 69) received weight-adjusted dose (15 mg/kg every 3 weeks [q3w]; maximum 1200 mg); those ≥ 18) flat...
2519 Background: CLDN18.2 expression has been observed in various solid tumors especially gastric cancer, indicating its potential as a novel target for anti-tumor therapy. IBI389 is an anti-CLDN18.2/CD3 bispecific antibody that induces immune synapse formations by linking CD3 molecules T-cell receptor complexes and antigens on the membrane of tumor cells. Herein, we report preliminary results from phase I study to evaluate safety efficacy patients (pts) with advanced tumors. Methods:...
Background Digestive system cancers are among the most common malignancies, exhibiting consistently high incidence and mortality rates, yet effective detection treatment targets remain limited. Integrin αv (ITGAV, CD51) is a significant member of integrin family, widely recognized for its role in mediating interactions between cells extracellular matrix, as well intracellular signaling. In recent years, ITGAV has been found to have significantly elevated expression multiple tumors, such...
ABSTRACT Background In patients with locally advanced cervical cancer (LACC) undergoing concurrent chemoradiotherapy (CCRT), the high incidence of radiation‐induced lymphopenia significantly affects prognosis. There are significant variations in lymphocyte count (ALC) recovery patterns among patients, and their impact on prognosis remains unclear. This study aims to quantify by index (LRI) evaluate its prognostic value. Methods reviewed LACC who had ALCs available within 6 months post‐CCRT....