A5064342343- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Complement system in diseases
- CAR-T cell therapy research
- Biosimilars and Bioanalytical Methods
- Lipoproteins and Cardiovascular Health
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Parasitic Infections and Diagnostics
- T-cell and B-cell Immunology
- Global Public Health Policies and Epidemiology
- Computational Drug Discovery Methods
- Research on Leishmaniasis Studies
- Advanced Image and Video Retrieval Techniques
- Herpesvirus Infections and Treatments
- Urinary Tract Infections Management
- Immune Cell Function and Interaction
- Advanced Neural Network Applications
- Trypanosoma species research and implications
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Immunotherapy and Immune Responses
- Pharmaceutical studies and practices
- Cytomegalovirus and herpesvirus research
- Intraocular Surgery and Lenses
Loma Linda University
2022-2025
University of Washington
2024
Novartis (United States)
2024
UCLA Medical Center
2024
Harbor–UCLA Medical Center
2024
Intel (United Kingdom)
2023
Taipei Medical University
2021
Wan Fang Hospital
2021
Centers for Disease Control and Prevention
2017-2021
Museum of Heilongjiang Province
2021
Background. Studies of Clostridium difficile outbreaks suggested that certain ribotypes (eg, 027 and 078) cause more severe disease than other ribotypes. A growing number studies challenge the validity this hypothesis. Methods. We conducted a cross-sectional study C. infection (CDI) to test whether ribotype predicted clinical severity when adjusted for influence predictors. Toxigenic isolates were cultured from stool samples, screened genes encoding virulence factors by polymerase chain...
The clinical success of the immune checkpoint inhibitor (ICI) targeting programmed cell death protein 1 (PD-1) has revolutionized cancer treatment. However, full potential PD-1 blockade therapy remains unrealized, as response rates are still low across many types. Interleukin-2 (IL-2)-based immunotherapies hold promise, they can stimulate robust T expansion and enhance effector function - activities that could synergize potently with blockade. Yet, IL-2 therapies also carry a significant...
Toxocariasis results from infection with larval stages of a dog and cat intestinal nematode causes human morbidity. The current United States estimate Toxocara exposure is 13.9% (National Health Nutrition Examination Survey [NHANES] III [1988-1994]).We used multiplex bead-based assay (Tc-CTL-1MBA) purified canis antigen to antibody seroprevalence in serum 13 509 persons aged ≥6 years NHANES 2011-2014 identified seropositivity risk factors. We tested subset 500 samples the T. enzyme...
Abstract Background Antimicrobial resistance (AMR) is expected to be a global health security risk in Africa coming decades. While AMR data available from Malawi public hospitals, Malawi’s burgeoning private hospital sector limited. Initial Hospital Antibiogram Data, Fall 2021 - Spring 2022 Methods An antibiogram was obtained for clinical blood and urine cultures October through April at referral southern (n=684). Logistic regression used assess patient-related determinants of AMR, as well...
Data on the burden of extended-spectrum β-lactamase producing Enterobacterales are limited in Jamaica. This study aims to identify factors associated with isolation ceftriaxone-resistant patients at a private hospital Jamaica through retrospective case–control comparing and without 2021. The case subjects had least one isolate resistant ceftriaxone, controls culture, all cephalosporin resistance, including those growth. data extracted included antibiotics received, organism, sex, age. Older...
Background Vancomycin-resistant enterococcus (VRE) infections pose substantial challenges for the treatment and suppression of bone joint infections. Oritavancin, a long-acting lipoglycopeptide antibiotic, has shown promising in vitro activity against VRE. Limited data are available on using oritavancin caused by VRE, both (therapy to eliminate active infection) suppressive antimicrobial therapy (long-term antibiotic administration prevent infection recurrence patients at high risk that...
To examine the leading indications for penetrating keratoplasty.We retrospectively performed a chart review of 904 cases keratoplasty over 10-year period (1986-1995). Where possible, clinical indication was corroborated by pathological report.Leading included pseudophakic bullous keratopathy (PBK; 28.5%), regraft (22.4%), keratoconus (10.0%), Fuchs' dystrophy (7.6%), aphakic (ABK; 6.1%), herpetic (4.2%), bacterial infection physical trauma (4%), interstitial keratitis (3.7%), and corneal...
This study retrospectively evaluated CT-guided thoracic biopsies for diagnostic yield, accuracy and complications.A retrospective analysis of 384 patients (mean age 62.7 years; male/female = 251/133) who underwent 399 were performed evaluating complications. Correlations between age, procedure factors (biopsy-needle size, number passes, lesion-size, lesion-depth traversed lung-length) complications such as pneumothorax, haemothorax haemoptysis evaluated. A comparison fine needle aspiration...
Over the past several decades, frequency of antibacterial resistance in hospitals, including multidrug (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cause nosocomial infections, to virtually all approved agents emerging this pathogen. To address need for new treat MDR P. aeruginosa, we focused on inhibiting first committed step biosynthesis lipid A, deacetylation...
Accurately measuring antibody repertoire sequence composition in a small amount of blood is challenging yet important for understanding responses to infection and vaccination. We develop molecular identifier clustering-based immune sequencing (MIDCIRS) use it study age-related development diversification before during acute malaria infants (< 12 months old) toddlers (12-47 with 4-8 ml blood. Here, we show this accurate high-coverage repertoire-sequencing method can as few 1000 naive B cells....
Cancer immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), represents a breakthrough in cancer treatment, resulting unprecedented results terms overall and progression-free survival. Discovery development novel anti PD-1 inhibitors remains field intense investigation, where monoclonal antibodies (mAbs) antibody formats (e.g., isotype, bispecific mAb low-molecular-weight compounds) are major source future therapeutic candidates. HLX10, fully humanized IgG 4...
Advances in the design of permeable peptides and synthesis large arrays macrocyclic with diverse amino acids have evolved on parallel but independent tracks. Less precedent combines their respective attributes, thereby limiting potential to identify peptide ligands for key targets. Herein, we present novel 6-, 7-, 8-mer cyclic (MW 774–1076 g·mol–1) passive permeability oral exposure that feature thioether ring-closing common array formats, including DNA- RNA-templated synthesis. Each herein,...
Angiostrongyliasis is caused by infection and migration to the brain of larvae parasitic nematode Angiostrongylus cantonensis, or rat lungworm. Adult A. cantonensis reside in lungs definitive wild rodent host, where they produce passed feces, which are then ingested snails slugs (gastropods). Human typically occurs when gastropods containing mature inadvertently humans. Although human often asymptomatic involves transient mild symptoms, larval can lead eosinophilic meningitis, focal...
Kaposi's sarcoma-associated herpesvirus (also named human 8) is a gamma-herpesvirus that undergoes both lytic and latent infection. During infection, two viral elements are required: latency-associated nuclear antigen (LANA), which functions as an origin binding protein, the origin, resides within terminal repeats (TRs) of genome. Previously, we identified cis-elements TRs required for DNA replication: LANA sites (LBS1 LBS2 [LBS1/2]) GC-rich replication element (RE) upstream LBS1/2. To...
A healthy 16-year-old girl born and raised in Tucson, AZ, had screening confirmatory testing revealing Chagas disease; clinical evaluation established that she the indeterminate form of chronic disease with evidence likely autochthonous transmission. Trypanosoma cruzi DNA was detected by conventional polymerase chain reaction Triatoma rubida captured at her home.
Trichomoniasis is the most prevalent nonviral sexually transmitted infection (STI) in United States. It can present with vaginitis women and urethritis men, but often asymptomatic or occurs minimal symptoms. associated other STIs, adverse pregnancy outcomes pelvic inflammatory disease. For these reasons, health care provider awareness of trichomoniasis public importance.To assess practitioner knowledge, attitudes, practices concerning management, American College Obstetricians Gynecologists...
Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of eight molecules isopentenyl (IPP) with farnesyl (FPP) to generate C(55) undecaprenyl (UPP). It has been demonstrated that tetramic acids (TAs) are selective and potent inhibitors UPPS, but mode inhibition was unclear. In this work, we used a fluorescent FPP probe study possible TA binding at site. A photosensitive analogue designed synthesized for site interaction UPPS using photo-cross-linking mass...
To assess the feasibility of sleeveless bimanual phacoemulsification using Millennium Microsurgical System (Bausch and Lomb Surgical) by measuring wound temperature during phacoemulsification.In vitro laboratory.The system was used in 6 eye-bank eyes pulse mode 80-milllisecond 160-millisecond phaco burst width intervals. Wound temperatures were measured, wounds observed for thermal injury.In nonoccluded state at 100% power, maximum 43.8 degrees C. In occluded 30% 51.7 C after 70 seconds...
The magnitude of antibody responses varies across the individual proteins that constitute any given microorganism, both in context natural infection and vaccination with attenuated or inactivated pathogens. protein-specific factors underlying this variability are poorly understood. In 267 individuals exposed to intense seasonal malaria, we examined relationship between immunoglobulin G (IgG) 861 Plasmodium falciparum specific features these proteins, including their subcellular location,...
A 67-year-old male presented with fatigue, abdominal pain , and 30-pound weight loss over 3 months. Computerized tomography (CT) abdomen displayed ascites thickening enhancement of the peritoneum mottled nodular appearing as soft tissue consistent omental caking worrisome for peritoneal carcinomatosis. paracentesis revealed white blood cell count 2,500 98% lymphocytes serum albumin gradient 0.9 g/L. No acid-fast bacilli were seen by microscopic exam culture was negative. Purified protein...
Cetuximab, the first approved EGFR targeting therapeutic antibody, is currently used to treat colorectal cancer and head neck cancer. While effective, cetuximab associated with a higher rate of skin rash, infusion reactions, gastrointestinal toxicity, which was suggested be linked presence heterogeneous glycan contents on Fab SP2/0-produced cetuximab.To improve efficacy minimize toxicity inhibition treatment, we re-engineered by humanizing its regions minimizing generate HLX07.HLX07 binds...