A5046562421- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Maternal and Perinatal Health Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Regulation of Appetite and Obesity
- Reproductive Health and Contraception
- Gestational Diabetes Research and Management
- Neuroscience, Education and Cognitive Function
- Memory and Neural Mechanisms
- Birth, Development, and Health
- Embodied and Extended Cognition
- Vaccine Coverage and Hesitancy
- Hormonal Regulation and Hypertension
- Biochemical Analysis and Sensing Techniques
- Diversity and Career in Medicine
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Circadian rhythm and melatonin
- Preterm Birth and Chorioamnionitis
- Influenza Virus Research Studies
- Psychology of Moral and Emotional Judgment
- Sodium Intake and Health
- Adipose Tissue and Metabolism
University of Washington
2014-2023
Georgetown University
2014-2023
Seattle University
2018-2023
Research Network (United States)
2021-2023
Georgetown University Medical Center
2013-2023
American Congress of Obstetricians and Gynecologists
2012-2021
Washington University Medical Center
2021
George Washington University
2017-2021
California State University, Fresno
2021
University of California, San Francisco
2021
We evaluated the effects of lipophilic nonpeptide corticotropin-releasing hormone (CRH) type 1 receptor antagonist antalarmin on behavioral, neuroendocrine, and autonomic components stress response in adult male rhesus macaques. After oral administration, significant concentrations were detected systemic circulation cerebrospinal fluid by a mass spectrometry-gas chromatography assay developed specifically for this purpose. Pharmacokinetic dose-response studies suggested that an dose 20 mg/kg...
Previous research has shown that infants who display a high frequency of motor activity and negative affect at 4 months age are likely to be behaviorally inhibited toddlers. We examined social behaviors, maternal report temperament, salivary cortisol, baseline startle responses in sample children, some whom displayed age. Infants this temperamental profile were reported by their mothers as more shy compared with other children. also found 4-year-olds wary behavior during peer play exhibited...
We examined temporal changes in behavior, regional brain electrical activity (EEG), heart rate, cardiac vagal tone, the startle eyeblink response, and salivary cortisol during a task designed to elicit self-presentation anxiety group of 7-year-olds, some whom were classified as temperamentally shy. found that shy children displayed significantly greater increase anxious right, but not left, frontal EEG activity, rate became more demanding compared with their nonshy counterparts. However,...
Sterotyped fixed action patterns (FAPs) are elicited in rats by oral infusions of taste solutions. These taste-elicited FAPs can be classified as either ingestive or aversive. They reflect the palatability and modified learning physiological state animal. studies demonstrated that when rat is altered sodium depletion, pattern 0.5 M NaCl shifts from a mixture aversive components (while replete) to exclusively ones deplete). This shift reactivity occurred first time were made deplete. A...
Glucocorticoids and stress are known to influence the synthesis of corticotropin-releasing hormone (CRH) at a variety sites in brain, including hypothalamus amygdala. The recent cloning CRH receptor (CRH-R) enabled us determine whether glucocorticoids or influenced action via regulation CRH-R. We, therefore, used situ hybridization measure CRH-R messenger RNA (mRNA) levels hypothalamic paraventricular nucleus (PVN), anterior pituitary (AP), amygdala, bed stria terminalis (BNST) under several...
Abstract Background Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain also elicited by natural rewards incentive cues, raising possibility that some systems an independent function positive motivation, such as amplifying salience. Here we asked whether activation a limbic subsystem magnifies increase motivation for reward cues previously associated with reward, way might exacerbate...