A5010880932- Receptor Mechanisms and Signaling
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Health disparities and outcomes
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Acute Ischemic Stroke Management
- Geriatric Care and Nursing Homes
- Intergenerational Family Dynamics and Caregiving
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Older Adults Driving Studies
- Urban Transport and Accessibility
- Health and Wellbeing Research
- Cholinesterase and Neurodegenerative Diseases
- Migration, Aging, and Tourism Studies
- Tryptophan and brain disorders
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Synthesis of heterocyclic compounds
- Aging and Gerontology Research
University of Washington
2003-2024
St. Clair County Community College
2023
Mayo Clinic in Arizona
2017-2020
Mayo Clinic
2017-2020
WinnMed
2019
Improvement Service
2008-2009
Flinders University
1989-2008
Repatriation General Hospital
1994-2007
Harborview Medical Center
2001-2007
The University of Adelaide
2002
Background and Purpose —We wished to examine the effectiveness of an early hospital discharge home-based rehabilitation scheme for patients with acute stroke. Methods —This was a randomized, controlled trial comparing usual inpatient follow-up care. The carried out in 2 affiliated teaching hospitals Adelaide, South Australia. Participants were 86 stroke (mean age, 75 years) who admitted required rehabilitation. Forty-two received (median duration, 5 weeks), 44 continued conventional care...
Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc) neurons have been correlated with behavioral sensitization, the molecular pathways governing these structural changes, and their resulting effects, are poorly understood. The transcription factor, nuclear factor kappa B (NFkappaB), is rapidly activated by diverse stimuli regulates expression of many genes known to maintain cell structure. Therefore, we evaluated role NFkappaB regulating spine medium spiny...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptorBarry S. Orlek, Frank E. Blaney, Brown, Michael G. Clark, Hadley, John Hatcher, Graham J. Riley, Howard Rosenberg, Harry Wadsworth, Paul WymanCite this: Med. Chem. 1991, 34, 9, 2726–2735Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September...
To assess the value of vertebral body endplate signal intensity (Modic) changes on magnetic resonance (MR) images in predicting a painful disk, with provocative diskography as reference standard.Lumbar spine diskograms and prediskogram MR 736 patients (2457 disks) were retrospectively reviewed part an institutional review board-approved HIPAA-compliant protocol. Each disk was assigned Modic subtype: type 0, normal; 1, nonfatty high intensity; 2, fatty; 3, sclerosis. Statistical analysis...
The goal of the present study was to examine resource and economic implications an early hospital discharge home-based rehabilitation scheme for patients with acute stroke.A cost minimization analysis in conjunction a randomized controlled trial carried out at 2 affiliated teaching hospitals southern metropolitan region Adelaide, South Australia, between 1997 1998. Eighty-six hospitalized stroke who required were receive both rehabilitation, or conventional in-hospital community care. Direct...
Objectives: To determine whether education and counselling after stroke leads to improved family functioning psychosocial outcomes for patients their spouses, better functional social patients. Design: Two-group randomized controlled trial. Data were collected on admission discharge from rehabilitation, again six months later. Setting: Rehabilitation units at Repatriation General Hospital Griffith Hospital, in Adelaide, South Australia. Participants: Sixty-two 32 the intervention group 30...
Wide variation in the experience of aging is increasingly recognized and models for identifying groups based on how “successfully” individuals are have taken many forms. This study used criteria developed MacArthur studies successful to identify subgroups with higher, intermediate, or lower levels function, compare them across a range other domains. Data were drawn from Australian Longitudinal Study Aging (ALSA) Adelaide, Australia, which population–based, bio–psycho–social cohort 1947...
Abstract The mechanism by which chronic caregiving stress results in poor health is not well understood. objective was to determine whether such a may be allostatic load, novel concept specifying physiological systems that suffer cumulative wear and tear following stress, leading collectively health. study examines the association of load with environmental psychological contexts dementia relinquishment care, 2-year longitudinal comparison three groups: 80 new spouse caregivers, 120 veteran...
5-HT<sub>1B</sub> autoreceptors have been implicated in animal models of stress and are regulated selectively by serotonin-selective reuptake inhibitors such as fluoxetine. These terminal regulate serotonin release from dorsal raphe nucleus (DRN) projections throughout rat forebrain. However, it has not previously possible to manipulate autoreceptor activity without also changing other neurons mediating different behavioral responses. Therefore, we developed a viral-mediated gene transfer...
We have previously demonstrated an augmentation of serotonergic activity within various brain areas following infusion brain-derived neurotrophic factor (BDNF) into the midbrain near periaqueductal gray and dorsal median raphe nuclei (PAG/DR). However, mechanism this BDNF-induced modulatory effect on systems was unclear. The aim present work to study regulation tryptophan hydroxylase (TPH) mRNA levels after chronic BDNF administration invivo. TPH were measured using a quantitative...
Background: Silent brain infarction (SBI) is defined as the presence of 1 or more lesions, presumed to be because vascular occlusion, found by neuroimaging (magnetic resonance imaging computed tomography) in patients without clinical manifestations stroke. It common than stroke and can detected 20% healthy elderly people. Early detection SBI may mitigate risk offering preventative treatment plans. Natural language processing (NLP) techniques offer an opportunity systematically identify cases...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and muscarinic activities of quinuclidin-3-yltriazole -tetrazole derivativesHarry J. Wadsworth, Sarah M. Jenkins, Barry S. Orlek, Frederick Cassidy, Michael G. Clark, Frank Brown, Graham Riley, Diane Graves, Julie Hawkins, Christopher B. NaylorCite this: Med. Chem. 1992, 35, 7, 1280–1290Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April...
Abstract Background The rapid adoption of electronic health records (EHRs) holds great promise for advancing medicine through practice-based knowledge discovery. However, the validity EHR-based clinical research is questionable due to poor reproducibility caused by heterogeneity and complexity healthcare institutions EHR systems, cross-disciplinary nature team, lack standard processes best practices conducting research. Method We developed a data abstraction framework standardize process...
Abstract Depression and anxiety disorders are among the leading causes of morbidity, mortality, disability in United States. Impaired serotonin neurotransmission appears to be a central mechanism inducing depressive symptoms. Most serotonergic innervation forebrain arises from median raphe nucleus (MRN) dorsal (DRN). The DRN displays complex internal morphology, with distinct subregions varying across anteroposterior (A‐P) axis. However, many studies have considered as whole or used easily...
SummaryGoal attainment scaling (GAS) is a procedure for evaluating the effectiveness of intervention in human service programmes. The theory and GAS are described, its strict requirements discussed. An example application rehabilitation centre physically disabled children reported. Problems with as an evaluation discussed, suggestions made dealing these problems.RésuméGoal Attainment Scaling (l'Evaluation de la Réalisation des Objectifs) est un procéde utilisé pour évaluer l'efficacité...
A recently identified and treatable cause of spontaneous intracranial hypotension (SIH) is cerebrospinal fluid (CSF)-venous fistula, a described computed tomography myelogram (CTM) finding highly compatible with but not diagnostic this entity the hyperdense paraspinal vein sign. We aimed to retrospectively measure prevalence sign on CTMs in SIH patients without dural CSF leak, comparison control groups.Three CTM groups were identified: 1) study group, which included leak-negative standard...
Objectives: To confirm, in a new sample, the value of our previously described procedure for identifying abnormal illness behaviour (AIB) stroke rehabilitation patients, and to examine relative effects AIB, depression, family functioning, knowledge stroke, expectations on long-term outcome. Design: A longitudinal design, with assessments admission discharge from rehabilitation, six twelve months after discharge. Setting: The study was undertaken unit at Repatriation General Hospital,...