A5039213849- Alzheimer's disease research and treatments
- Medieval Literature and History
- Historical Studies of British Isles
- Linguistics and language evolution
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Byzantine Studies and History
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Parkinson's Disease Mechanisms and Treatments
- Historical and Religious Studies of Rome
- Nuclear Receptors and Signaling
- Prion Diseases and Protein Misfolding
- Classical Antiquity Studies
- Neurotransmitter Receptor Influence on Behavior
- Ubiquitin and proteasome pathways
- Scottish History and National Identity
- Ginkgo biloba and Cashew Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Historical and Linguistic Studies
- Supramolecular Self-Assembly in Materials
- Neuropeptides and Animal Physiology
- Reformation and Early Modern Christianity
- Medieval European Literature and History
- Drug Transport and Resistance Mechanisms
University of Oxford
1974-2023
King's College London
2011-2022
Age UK
2012
GlaxoSmithKline (China)
2012
GlaxoSmithKline (United Kingdom)
2002-2011
British Library
2000-2008
Bodle Technologies (United Kingdom)
2007
Science Oxford
1974-2006
Molecular Discovery (United Kingdom)
1999
The University of Melbourne
1999
<h3>Context</h3> Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). <h3>Objective</h3> To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. <h3>Design</h3> Discovery-phase proteomics to correlates pathology. Confirmation validation immunodetection replication set an animal model. <h3>Setting</h3> A multicenter European study (AddNeuroMed) the Baltimore Longitudinal Study Aging....
MAPK-activated protein kinase 2 (MAPKAP K2 or MK2) is one of several kinases directly regulated by p38 MAPK. A role for MAPK in the pathology Alzheimer disease (AD) has previously been suggested. Here, we provide evidence to suggest that MK2 also plays a neuroinflammatory and neurodegenerative relevance AD. activation expression were increased lipopolysaccharide (LPS) + interferon γ-stimulated microglial cells, implicating eliciting pro-inflammatory response. Microglia cultured ex vivo from...
Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by the presence of α-synuclein-containing neurites. However, both dementias also show variable degrees Alzheimer's (AD) pathology (senile plaques neurofibrillary tangles), particularly in areas cortex associated higher cognitive functions. This study investigates contribution individual combined pathologies determining rate decline. Cortical α-synuclein, phosphorylated tau (phosphotau) Aβ plaque 34 PDD...
The beta-amyloid (Abeta) peptide, a major component of senile plaques in Alzheimer's disease brain, has been shown previously to undergo process polymerization produce neurotoxic forms amyloid. Recent literature attempted define precisely the form Abeta responsible for its neurodegenerative properties. In present study we describe novel density-gradient centrifugation method isolation and characterization structurally distinct polymerized peptide. Fractions containing protofibrils, fibrils,...
1. In rat isolated thoracic aortic rings pre-contracted with noradrenaline (10(-6) M), cromakalim (3 x 10(-7)-3 10(-5) M) produced concentration-related relaxation. This effect was progressively inhibited by increasing concentrations of the anti-diabetic sulphonylurea drug, glibenclamide (10(-6)-10(-5) M). 2. portal veins, 10(-8)-10(-6) inhibition spontaneous contractive activity and 10(-6) prevented this inhibitory action in a concentration-dependent manner. 3. both (10(-5) stimulated 86Rb...
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes early risk factors AD (Alzheimer's disease). An essential feature pathology is the presence BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which regulates production toxic peptides. However, whether also plays a role in presently unknown. We have used transgenic mice to analyse effects loss on body weight, lipid homoeostasis. BACE1-/- lean, with decreased adiposity, higher energy...
Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play role in risk reduction dementia. Amyloid precursor protein processing and the subsequent generation amyloid beta (Aβ) are central pathogenesis Alzheimer's disease, as soluble, oligomeric Aβ is thought be toxic species driving disease progression. We undertook an vitro screen identify flavonoids with bioactivity at βγ-mediated processing, which...
Abstract Orexins are neuropeptides that regulate the sleep-wake cycle and feeding behaviour. QRFP is a newly discovered neuropeptide which exerts similar orexigenic activity, thus playing an important role in energy homeostasis regulation of appetite. The exact expression signalling characteristics physiological actions its receptor GPR103 poorly understood. Alzheimer’s disease (AD) patients experience increased nocturnal excessive daytime sleepiness weight loss. We hypothesised therefore...
Alzheimer's disease (AD) is characterized by accumulation of β-amyloid plaques (AP) and neurofibrillary tangles (NFT) in the cortex, together with synaptic loss amyloid angiopathy. Perturbations brain lysosomal system, including cathepsin family proteases, have been implicated AD where they may be involved proteolytic clearance misfolded abnormally aggregated peptides. However, status D (catD) unclear Lewy body dementia, second most common form neurodegenerative dementia after AD, bodies...
A series of benzofuran derivatives have been identified as inhibitors fibril formation in the β-amyloid peptide. The activity these compounds has assessed by a novel fibril-formation-specific immunoassay and for their effects on production biologically active product. inhibition afforded seems to be associated with binding β-amyloid, scintillation proximity assay. Binding assays NMR studies also indicate that is self-aggregation compounds. There close correlation between benzofurans ability...
Porphyrins related to the naturally occurring pigment heme were found effectively interfere with aggregation of beta-amyloid peptides as determined by an immunoassay configured for detection oligomers. Oligomerisation is believed be a key event in progression Alzheimer's disease. Inhibition this thus important strategy combating commonest form senile dementia. Evidence was also generated hemin and hematin mediated protection cultured cells against neurotoxic effects beta-amyloid. These data...
[3H]Spiperone, a neuroleptic/dopamine receptor ligand, binds with high affinity (Kd 0.15 nM) to single specific site on rat corpus striatum membranes. The binding represents about 80% of the total and is displaced by dopamime, apomorphine, stereospecifically neuroleptics such as butaclamol flupenthixol. However, in contrast striatum, only 30-40% [3H]spiperone limbic forebrain membranes or flupenthixol, whereas dopamine certain spiperone analogues compete for 70% labeled sites. These...
Collapsin response mediator protein 2 (CRMP2) is an abundant brain-enriched that regulates neurite outgrowth. It phosphorylated by Cdk5 and GSK3, these modifications are abnormally high in the brains of Alzheimer's disease (AD) patient