A5041146029- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Advanced MRI Techniques and Applications
- Anesthesia and Pain Management
- Renal function and acid-base balance
- Trauma and Emergency Care Studies
- Functional Brain Connectivity Studies
- Sepsis Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Law, logistics, and international trade
- Blood transfusion and management
- Adrenal and Paraganglionic Tumors
- Cardiovascular Issues in Pregnancy
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Nausea and vomiting management
- Construction Engineering and Safety
- Anesthesia and Neurotoxicity Research
- Magnesium in Health and Disease
- Blood Pressure and Hypertension Studies
- Migraine and Headache Studies
- Respiratory Support and Mechanisms
University of Cape Town
2013-2023
NorthEast Regional Epilepsy Group
2018
Groote Schuur Hospital
2002-2015
University of California, San Francisco
2013-2015
Cardiff and Vale University Health Board
2015
Queen Fabiola Children's University Hospital
2013
Centre Hospitalier Universitaire Brugmann
2013
University College London
1979-2012
Nineveh Charitable Trust
2011
GlaxoSmithKline (United Kingdom)
2001-2009
Hemodynamic responses to vasopressors used during spinal anesthesia for elective Cesarean delivery, have not been well described. This study compared the effects of bolus phenylephrine and ephedrine on maternal cardiac output (CO). The hypothesis was that phenylephrine, but ephedrine, decreases CO when administered in response hypotension anesthesia.Forty-three patients were randomized receive 80 microg or 10 mg ephedrine. Both pulse wave form analysis transthoracic bioimpedance changes...
To investigate dexmedetomidine in children, the authors performed an open-label study of pharmacokinetics and pharmacodynamics dexmedetomidine.Thirty-six children were assigned to three groups; 24 received 12 no drug. Three doses dexmedetomidine, 2, 4, 6 microg x kg h, infused for 10 min. Cardiorespiratory responses sedation recorded h. Plasma concentrations collected h analyzed. Pharmacokinetic variables determined using nonlinear mixed effects modeling (NONMEM program). analyzed.Thirty-six...
Current methods of crystalloid preload administration prior to spinal anaesthesia for elective caesarean section are relatively ineffective in preventing hypotension. This study examined the relevance timing fluid administered. Fifty women were randomly allocated receive either 20 ml.kg –1 solution during minutes induction (preload), or an equivalent volume by rapid infusion immediately after (coload). Significantly more patients coload group did not require vasopressor therapy pre-delivery...
Hemodynamic responses to spinal anesthesia (SA) for cesarean delivery in patients with severe preeclampsia are poorly understood. This study used a beat-by-beat monitor of cardiac output (CO) characterize the response SA. The hypothesis was that CO would decrease from baseline values by less than 20%.Fifteen consented an observational study. employed pulse wave form analysis estimate nominal stroke volume. Calibration lithium dilution. and systemic vascular resistance were derived measured...
The effects of pre-treatment with 60 mg/kg body weight magnesium sulfate intravenous on cardiovascular responses and catecholamine release associated tracheal intubation were measured in 15 normal patients saline solution pre-treated controls. Magnesium increased heart rate by 13 +/- 3.9 beats/minute. After intubation, was unchanged the group at 107.3 3.6 beats/minute but control to 120.9 4.6 (P less than 0.05). Systolic blood pressure after from 106.8 3.1 121.0 4.4 mm Hg given 106.4 3.12...
In Brief Pheochromocytoma crisis is a rare life-threatening event that may appear with variety of clinical symptoms. We present three cases in which magnesium sulfate was particularly beneficial controlling symptoms and signs when more conventional forms therapy had failed. Two patients presented hypertensive encephalopathy, the third catecholamine-induced cardiomyopathy. All successfully underwent tumor excision used as sole drug for control hemodynamic disturbances during surgery. The...
Background There are no randomized studies on neonatal outcome after spinal versus general anesthesia for cesarean delivery in preeclamptic patients with a nonreassuring fetal heart trace. This study examined both markers of hypoxia and maternal hemodynamics. Methods Seventy were to (n = 35) or 35). The group received thiopentone, magnesium sulfate, suxamethonium intravenously before intubation, followed by 50% nitrous oxide oxygen, 0.75-1.5% isoflurane, morphine delivery. target end-tidal...
The present study was conducted in 100 patients receiving retrobulbar block for ophthalmic surgery to compare the efficacy of local anesthetic solutions with and without hyaluronidase. All received 3.5 ml a mixture 3 0.5% bupivacaine 2 2% lidocaine. Seventy-five international units hyaluronidase were diluted 5 used 50 blocks. remainder did not receive A consistently better motor blockade achieved (P less than 0.001 at 10, 15, 20 min). This finding has been conclusively demonstrated before.
Spreading depression (SD) has long been associated with the underlying pathophysiology of migraine. Evidence that <i>N</i>-methyl-d-aspartate (NMDA) glutamate receptor (NMDA-R) is implicated in generation and propagation SD itself available for more than 15 years. However, to date, there are no reports NMDA-R antagonists being developed migraine therapy. In this study, an uncompetitive, pan-NMDA-R blocker, memantine, approved clinical use, two selectivity containing NR2B subunit,...
Both fluid composition (e.g., type of hydroxyethyl starch) and formulation saline or balanced salt carrier solution) may alter whole blood coagulation. We therefore enrolled 10 healthy volunteers to test ex vivo, thrombelastograph-based coagulation differences eight crystalloid colloid solutions at 20%, 40%, 60% dilutions. Saline lactated Ringer's solution produced a hypercoagulable state 20%-40% Saline, hetastarch in saline, pentastarch tetrastarch human albumin all hypocoagulable dilution....