A5034020160- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cell Image Analysis Techniques
- Medical Image Segmentation Techniques
- Quantum Computing Algorithms and Architecture
- Spectroscopy and Chemometric Analyses
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Quantum Information and Cryptography
- Neuroscience and Neuropharmacology Research
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Health, Environment, Cognitive Aging
- Quantum and electron transport phenomena
- Receptor Mechanisms and Signaling
- Synthesis and Reactions of Organic Compounds
- Spectroscopy and Quantum Chemical Studies
- Molecular spectroscopy and chirality
- Amino Acid Enzymes and Metabolism
- Gene expression and cancer classification
- Functional Brain Connectivity Studies
Medicines Discovery Catapult
2024
Daresbury Laboratory
2020
Sci-Tech Daresbury
2020
AstraZeneca (United Kingdom)
2012-2019
Siemens (Germany)
2015
University of Tübingen
2015
Imaging Center
2015
Society of Interventional Radiology
2015
University of Manchester
1995-2010
GlaxoSmithKline (United Kingdom)
2004-2009
Six pulse sequences are described, all based on the stimulated echo, for use in high resolution diffusion-ordered spectroscopy (HR-DOSY). HR-DOSY requires spectra with clean baselines, pure phases and lineshapes that independent of field gradient amplitude. Lineshape problems arising from static perturbations caused by pulses phase errors zero quantum coherence strongly coupled spin systems discussed, performance six is compared. Pulse which balanced pairs antiphase show significant...
There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship T1 -weighted oxygen-enhanced magnetic resonance (OE-MRI) measurements to histopathology in murine glioma xenograft demonstrated technique translation human glioblastoma multiforme.
Non-invasive imaging biomarkers underpin the development of molecularly targeted anti-cancer drugs. This study evaluates tumour apparent diffusion coefficient (ADC), measured by diffusion-weighted magnetic resonance (DW-MRI), as a biomarker response to MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) in human xenografts. Nude mice bearing BRAFV600D WM266.4 melanoma or BRAFV600E Colo205 colon carcinoma xenografts were treated for 4 days with vehicle selumetinib. DW-MRI was performed before...
Solid tumours exhibit enhanced vessel permeability and fenestrated endothelium to varying degree, but it is unknown how this varies in patients between within tumour types. Dynamic contrast-enhanced (DCE) MRI provides a measure of perfusion permeability, the transfer constant K
To improve the clinical translation of anti-cancer nanomedicines, it is necessary to begin building specific insights into broad concept Enhanced Permeability and Retention (EPR) effect, using detailed investigations accumulation, distribution retention nanomedicines in solid tumors. Nanomedicine accumulation preclinical tumors has been extensively studied; however, treatment efficacy will be heavily influenced by both quantity drug-loaded reaching tumor as well their spatial throughout...
The phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising therapeutic target. AZD8186 (AstraZeneca) PI3Kβ/δ inhibitor, currently phase 1 clinical trials. (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) often used as biomarker for inhibitors targeting the PI3K axis because of association this with glucose metabolism. In study, we assessed if (18)F-FDG PET could be pharmacodynamic marker to monitor PI3Kβ inhibition...
Background The phosphatidyl inositol 3 kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) signal transduction pathway is frequently de-regulated activated in human cancer an important therapeutic target. AZD8835 a PI3K inhibitor, with selectivity against α δ isoforms, which currently Phase 1 clinical trials. 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) non-invasive pharmacodynamic imaging biomarker that has become integral part drug development. It been used...
We aimed to quantitatively characterize the treatment effects of docetaxel in HCT116 xenograft mouse model, applying diffusion-weighted magnetic resonance imaging (MRI) and positron emission tomography (PET) using 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ F]FDG) 3′-deoxy-3′-[ F]-fluorothymidine F]FLT). Mice were imaged at four time points over 8 days. Docetaxel (15 mg/kg) was administered after a baseline scan. Voxel-wise scatterplots PET apparent diffusion coefficient (ADC) data tumor volumes...
The interest in BOLD contrast based phMRI is likely to increase the coming years, but detecting a direct modulation of regional brain activity by drugs presents challenging problem. Based on in-vivo MRI and simulations we highlight some issues especially small signals rat experiments.