A5019267444- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Crystallization and Solubility Studies
- Microencapsulation and Drying Processes
- Granular flow and fluidized beds
- Protein purification and stability
- Adsorption, diffusion, and thermodynamic properties of materials
- Advanced Cellulose Research Studies
- Powder Metallurgy Techniques and Materials
- Electrohydrodynamics and Fluid Dynamics
- Injection Molding Process and Properties
- Analytical Chemistry and Chromatography
- Advanced Drug Delivery Systems
- Mineral Processing and Grinding
- Spectroscopy and Chemometric Analyses
- Polysaccharides Composition and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced NMR Techniques and Applications
- Scientific Measurement and Uncertainty Evaluation
- Fluid Dynamics and Mixing
- Fluid Dynamics and Heat Transfer
- NMR spectroscopy and applications
- Process Optimization and Integration
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
Bristol-Myers Squibb (United Kingdom)
2014-2024
Bristol-Myers Squibb (United States)
2016
Bristol-Myers Squibb (Germany)
2009-2015
University of Bath
1996-2008
Vectura (United Kingdom)
2004
University of Strathclyde
1997
Atomic force microscopy (AFM) was used to investigate drug-carrier interactions between beclometasone dipropionate (BDP) and a series of untreated modified lactose surfaces. This quantitative information correlated with bulk characterization methods an in-vitro study. Modified surfaces were prepared using proprietary process referred as "particle smoothing" obtain smooth carrier or without the presence magnesium stearate. The engineering particle smoothing resulted in significant differences...
Microcrystalline cellulose (MCC) is regarded as one of the most versatile tablet filler binders, finding a wide use in both granulation and direct compression operations. It has been shown that MCC particle populations consist mixture 'rod like' primary particles, agglomerates, proportion these particles agglomerates differs within different grades materials, contributing to bulk properties materials. However, not previously fully elucidated, their contribution performance factors such flow...
The bioavailability of insoluble crystalline active pharmaceutical ingredients (APIs) can be enhanced by formulation as amorphous solid dispersions (ASDs). One the key factors ASD stabilization is formation drug–polymer interactions at molecular level. Here, we used a range multidimensional and multinuclear nuclear magnetic resonance (NMR) experiments to identify these in acetaminophen (paracetamol)/hydroxypropylmethylcellulose acetyl succinate (HPMC-AS) ASDs various drug loadings. At low...
Amorphous forms of poorly soluble drugs are more frequently being incorporated into solid dispersions for administration and extensive research has led to a reasonable understanding how these dispersions, although still kinetically unstable, improve stability relative the pure amorphous form. There remains however paucity literature describing effects on such subsequent processing dosage as tablets. This paper addresses this area by looking at addition common excipients different...