Atomic force microscopy (AFM) was used to investigate drug-carrier interactions between beclometasone dipropionate (BDP) and a series of untreated modified lactose surfaces. This quantitative information correlated with bulk characterization methods an in-vitro study. Modified surfaces were prepared using proprietary process referred as "particle smoothing" obtain smooth carrier or without the presence magnesium stearate. The engineering particle smoothing resulted in significant differences...

As drug delivery to the eye has evolved over last decades, researchers have explored more effective treatments for ocular diseases. Despite this, delivering drugs cornea remains one of most problematic issues in ophthalmology due poor permeability and tear clearance mechanisms. In this study, four different types polyaphron formulations are prepared with 10% poloxamer 188 (P188), poly(2-ethyl-2-oxazoline), 1% polyquaternium 10, 3% sodium carboxymethylcellulose solutions mixed Brij® L4 a...

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The compaction behavior of three "as supplied" commercially available grades sodium starch glycolate (SSG), Explotab, Primojel, and Vivastar P, was investigated at compression speeds 0.17 30 mm/sec. results suggested that the materials exhibit different behavior. Primojel Explotab exhibited similar compactibility, whereas P produced compacts poor integrity. This not mirrored in compressibility powders, where performance. were studied using x-ray diffraction, scanning electron microscopy,...

The adsorption of a model amine drug (tacrine hydrochloride) from aqueous solution onto 21 microcrystalline cellulose (MCC) based samples has been investigated. MCC source (manufacturer) affected adsorption. appeared to be fully reversible. Adsorption was reduced by the use high-density grade MCC, high-energy milling, and silicification. not particle size MCC. Significant variations characteristics between batches certain products were found. primary mode ion exchange.

Dynamic vapor sorption (DVS) was used to determine the moisture properties of sodium starch glycolates. The results were compared similarly obtained data for potato starch, pregelatinized microcrystalline cellulose (MCC), and crystalline lactose. As expected, glycolates exhibit a large mass gain at 90% relative humidity (RH), other anhydroglucose-based excipients. However, capacities modified starches between 10%-70% RH similar. Analysis DVS using Brunauer-Emmett-Teller (BET) Guggenheim,...

Effective topical drug delivery is the essence of dermatologic treatment. The must be applied to skin surface, released from vehicle, enter stratum corneum, traverse epidermis, and dermis pharmacologically intact. New advances have improved emulsion-type formulation technology by encapsulating dispersed oil droplets in a robust multimolecular aqueous film surfactants, oil, water, enabling multifold decrease surfactant concentration compared conventional creams. In research reported here, we...

The mechanical properties of compacts microcrystalline cellulose (MCC) and silicified (SMCC) were evaluated by tensile testing, diametric compression testing. For cubic specimens carefully machined from MCC SMCC compacts, the strengths both normal parallel to compaction direction. compared values obtained test. results using test suggested exhibit greater strength than those MCC. In addition, cubes exhibited directional strength; direction display ed strength, had strength. afforded with...

High density microcrystalline cellulose (MCC) is a relatively free flowing grade of MCC that finds use in direct compression tableting and hard gelatin capsule filling applications. Silicified high has recently been introduced. This material compared to other grades previously silicified (SMCC). The results suggest that, as observed for SMCC, the exhibits no detectable chemical or polymorphic differences standard material, some improvement flow characteristics, but shows considerably...

Silicified microcrystalline cellulose (SMCC) is a novel tableting excipient which has been reported to exhibit improved binding capability as material and in formulations. The also show resistance the deleterious effects of magnesium stearate compared with conventional cellulose. To understand improvement functionality silicified location silicon dioxide SMCC was investigated by studying particle surfaces cross-sections using scanning electron microscopy together probe...

The relationship between the apparent moisture content and sorption of modified starches was investigated. Samples sodium starch glycolate (SSG), pregelatinized (PGS) potato (PS) were stored for various times at 44% or 75% relative humidity (RH) to produce samples with contents up 14%, as determined by loss on drying (LOD). Evaluation LOD mass gain data suggested that measured equated predicted values PGS PS. However, in SSG there a nonstoichiometric LOD. In addition, displayed hysteresis...

A modified method for the carbon and oxygen isotope analysis of "small samples' (<100 μg) common, naturally occurring carbonate minerals (calcite, dolomite, siderite) using conventional phosphoric acid digestion techniques is described. Samples are reacted in vacuo with ca. 30 μL anhydrous resultant sample CO2 processed via a purpose-built, manual gas clean-up line which attached directly to inlet stable ratio mass spectrometer. Comparisons between isotopic values obtained from well...

The relationship between the apparent moisture content and compactibility of sodium starch glycolate was compared to similarly obtained data for pregelatinized starch. Samples (SSG) pregelatinised (PGS) were stored at 44% or 75% relative humidity (RH), producing samples exhibiting contents up 14% w/w, as determined by loss on drying (LOD). Increasing SSG PGS resulted in an increase compressibility both materials. However, effect more dramatic with unlubricated compactibilities 2.0 MPa 0.9...

The chemical reprocessing of irradiated nuclear fuel involves the handling highly radioactive and often hot or corrosive solutions, usually containing nitric acid. This demands plant constructed to a high standard integrity from suitably resistant materials. difficulty carrying out maintenance repair active which fails due corrosion means that an adequate allowance, based on reliable data, must be included at design stage. data base allowance are gathered small‐and rig‐scale laboratory...

Abstract A recent advance in metallurgical technology has been the application of rapid solidification techniques to Al alloy production. FVS0812 is designation given a microcrystalline Al‐based consisting 8 wt% Fe, 1 V and 2 Si. It two‐phase alloy, ca. 27 vol percent approximately spherical Fe‐V‐Si‐rich dispersoids an essentially pure matrix. The high strength, low density properties this advanced material, other related alloys, have not yet realized, however, due, part, inability form...