A5035250882- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Neurobiology of Language and Bilingualism
- Fatty Acid Research and Health
- Folate and B Vitamins Research
- Cerebrovascular and genetic disorders
- Brain Tumor Detection and Classification
- Health, Environment, Cognitive Aging
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Cholesterol and Lipid Metabolism
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Palsy and Movement Disorders
- Neural dynamics and brain function
Karolinska University Hospital
2014-2024
Karolinska Institutet
2015-2024
Stockholm University
2000-2022
RISE Research Institutes of Sweden
2022
Sahlgrenska University Hospital
2021
Stanford Medicine
2021
Lund University
2008-2019
Skåne University Hospital
2016-2019
Wellcome Centre for Human Neuroimaging
2019
King's College London
2019
Background and Purpose —MRI is more sensitive than CT for detection of age-related white matter changes (ARWMC). Most rating scales estimate the degree distribution ARWMC either on or MRI, they differ in many aspects. This makes it difficult to compare MRI studies. To be able study evolution possible effect drug treatment large patient samples, necessary have a scale constructed both CT. We developed evaluated new studied number patients examined with Methods —Seventy-seven were recruited...
Background: Epidemiologic and animal studies have suggested that dietary fish or oil rich in -3 fatty acids, for example, docosahexaenoic acid eicosapentaenoic acid, may prevent Alzheimer disease (AD).Objective: To determine effects of supplementation on cognitive functions patients with mild to moderate AD.Design: Randomized, double-blind, placebo-controlled clinical trial.Participants: Two hundred four AD (age range [mean±SD], 74 ± 9 years) whose conditions were stable while receiving...
Nerve growth factor (NGF) is important for the survival and maintenance of central cholinergic neurons, a signalling system impaired in Alzheimer's disease. We have treated 3 patients with disease total 6.6 mg NGF administered continuously into lateral cerebral ventricle months first 2 0.55 shorter periods third patient. The were extensively evaluated clinical, neuropsychological, neurophysiological neuroradiological techniques. Three after treatment ended, significant increase nicotine...
Age-related white matter changes (ARWMC) on brain MRI have been associated with cognitive, motor, mood and urinary disturbances. These factors are known to contribute disability in elderly people, but the impact of ARWMC their progression transition is not determined. The LADIS (Leukoaraiosis Disability Elderly) study aims at assessing role as an independent predictor initially nondisabled (65–84 years). Subjects who impaired or only 1 item Instrumental Activity Daily Living (IADL) scale,...
Tau protein and the 42-amino acid form of beta-amyloid (Abeta42) measured in cerebrospinal fluid (CSF) have been proposed as potential biochemical diagnostic markers for Alzheimer disease. For introduction these assays clinical practice, adequate reference values are importance.CSF samples were obtained from 231 neurologically psychiatrically healthy individuals, 21-93 years age, all with a MiniMental State examination score 28 or above. Standardized ELISAs used to measure tau Abeta42 CSF....
In neurodegeneration research, normalization of regional volumes by intracranial volume (ICV) is important to estimate the extent disease-driven atrophy. There little agreement as whether raw volumes, volume-to-ICV fractions or from which ICV factor has been regressed out should be used for volumetric brain imaging studies. Using multiple cortical and subcortical measures generated Freesurfer (51 in total), main aim this study was elucidate implications these adjustment approaches. Magnetic...
<b>Objective</b> To assess the impairment in daily living activities older people with age related changes white matter according to severity of these changes. <b>Design</b> Observational data collection and follow-up a cohort undergoing brain magnetic resonance imaging after non-disabling complaints. <b>Setting</b> 11 European centres. <b>Participants</b> 639 non-disabled patients (mean 74.1 (SD 5.0), 45.1% men) whom showed mild, moderate, or severe (Fazekas scale). Magnetic assessment also...
In the Leukoaraiosis and Disability (LADIS) Study, 11 European centers are evaluating role of age-related white matter changes (ARWMC) as an independent determinant transition to disability in elderly (65 84 years). We aimed at determining influence ARWMC on different objective measures gait balance.Six hundred thirty-nine nondisabled individuals were prospectively enrolled being followed-up for 3 years. Subjects graded three standardized categories (mild, moderate, severe) according central...
<h3>Context</h3> Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). <h3>Objective</h3> To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. <h3>Design</h3> Discovery-phase proteomics to correlates pathology. Confirmation validation immunodetection replication set an animal model. <h3>Setting</h3> A multicenter European study (AddNeuroMed) the Baltimore Longitudinal Study Aging....
We studied the natural course of white matter hyperintensities (WMH) and lacunes, main MRI representatives small vessel disease, over time evaluated possible predictors for their development.Baseline repeat (3-year follow-up) were collected within multicenter, multinational Leukoaraiosis Disability study (n=396). Baseline WMH scored on by Fazekas scale Scheltens scale. progression was assessed using modified Rotterdam Progression (absence/presence in 9 brain regions). new lacunes counted per...
Little solid information is available on the possible risks for neuronal injury in amateur boxing.To determine whether boxing and severity of hits are associated with elevated levels biochemical markers cerebrospinal fluid.Longitudinal study.Referral center specializing evaluation neurodegenerative disorders.Fourteen boxers (11 men 3 women) 10 healthy male nonathletic control subjects.The underwent lumbar puncture 7 to days months after a bout. The subjects LP once.Neurofilament light...
<h3>Objective:</h3> To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD). <h3>Methods:</h3> From prospective, longitudinal BioFINDER study, we included 122 healthy elderly 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). β-Amyloid (Aβ) deposition in 9 brain regions was examined [<sup>18</sup>F]-flutemetamol PET. analyzed INNOTEST EUROIMMUN ELISAs. The results were replicated 146...
The use of supplements with omega-3 (ω3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) is widespread due to proposed beneficial effects on the nervous cardiovascular systems. Many ω3 FAs are believed be caused by down-regulation resolution inflammation. Alzheimer's disease (AD) associated inflammation mediated microglia astrocytes, have been potential treatments for AD. focus present study DHA EPA microglial phagocytosis AD pathogen amyloid-β (Aβ), secreted...
Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits mild disease dementia. LipiDiDiet investigated effects on cognition and related measures prodromal Here, we report 24-month results trial.LipiDiDiet was a randomised, controlled, double-blind, parallel-group, multicentre trial (11 sites Finland, Germany, Netherlands, Sweden), with optional 12-month double-blind extensions. The enrolled individuals...
Abstract Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer’s disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking. We aimed (1) validate combined use visual rating scales for identification AD subtypes; (2) characterise these at baseline and over two years; (3) investigate how atrophy non-memory cognitive domains contribute memory impairment. patients were...
Abstract Introduction Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there no well‐established plasma markers. Methods A hypothesis‐led biomarker search was conducted in the context international multicenter studies. The discovery phase measured 53 inflammatory proteins elderly control (CTL; 259), mild cognitive impairment (MCI; 199), (262) subjects from AddNeuroMed. Results Ten analytes showed...
Background and Purpose- Cerebral small vessel disease is characterized by a wide range of focal global brain changes. We used magnetic resonance imaging segmentation tool to quantify multiple types disease-related changes examined their individual combined predictive value on cognitive functional abilities. Methods- Magnetic scans 560 older individuals from LADIS (Leukoaraiosis Disability Study) were analyzed using automated atlas- convolutional neural network-based methods yielding...
Introduction In the last few years, several models trying to calculate biological brain age have been proposed based on structural magnetic resonance imaging scans (T1-weighted MRIs, T1w) using multivariate methods and machine learning. We developed validated a convolutional neural network (CNN)-based prediction model that uses one T1w MRI preprocessing step when applying external datasets simplify implementation increase accessibility in research settings. Our only requires rigid image...
In 18 patients who were undergoing upper laparotomies the alveolo-arterial oxygen difference and right-to-left shunt measured before operation, on first post-operative day, in some cases also later period. The arterial tension was found to be considerably reduced post-operatively. estimated by hydrogen isotope technique moderately increased most instances, but increase far from large enough account for observed hypoxaemia. It is concluded that uneven distribution of ventilation relative...