A5058684228- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Prostate Cancer Treatment and Research
- Spine and Intervertebral Disc Pathology
- Cognitive Functions and Memory
- Myofascial pain diagnosis and treatment
- Systemic Sclerosis and Related Diseases
- Effects of Vibration on Health
- Functional Brain Connectivity Studies
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Musculoskeletal pain and rehabilitation
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Estrogen and related hormone effects
- Traumatic Brain Injury Research
- Moyamoya disease diagnosis and treatment
University of Eastern Finland
2021-2024
University of Helsinki
2018-2024
Helsinki University Hospital
2018-2024
Background and Purpose- Cerebral small vessel disease is characterized by a wide range of focal global brain changes. We used magnetic resonance imaging segmentation tool to quantify multiple types disease-related changes examined their individual combined predictive value on cognitive functional abilities. Methods- Magnetic scans 560 older individuals from LADIS (Leukoaraiosis Disability Study) were analyzed using automated atlas- convolutional neural network-based methods yielding...
Impairment of executive functions (EFs) is a common cognitive symptom post-stroke and affects independence in daily activities. Previous studies have often relied on brief tests not fully considering the wide spectrum EF subdomains. A detailed assessment EFs was used to examine which subdomains strongest predictive value functional outcome institutionalization long-term follow-up.A subsample 62 patients from Helsinki Stroke Aging Memory Study evaluated with battery seven neuropsychological 3...
Abstract Treatment of prostate cancer confronts resistance to androgen receptor (AR)-targeted therapies. AR-associated coregulators and chromatin proteins hold a great potential for novel therapy targets. Here, we employed powerful chromatin-directed proteomics approach termed ChIP-SICAP uncover the composition protein network, chromatome, around endogenous AR in castration resistant (CRPC) cells. In addition several expected coregulators, chromatome contained many nuclear not previously...
Cerebral small vessel disease is characterized by progressive white matter hyperintensities (WMH) and cognitive decline. However, variability exists in how individuals maintain capabilities despite significant neuropathology. The relationships between individual reserve, psychological resilience functioning were examined subjects with varying degrees of WMH.In the Helsinki Small Vessel Disease Study, 152 (aged 65-75 years) underwent a comprehensive neuropsychological assessment, evaluation...
Cognitive and motor impairments are the key clinical manifestations of cerebral small vessel disease (SVD), but their combined effects on functional outcome have not been elucidated. This study investigated interactions mediating cognitive functions instrumental activities daily living (IADL) quality life in older individuals with various degrees white matter hyperintensities (WMH).Participants Helsinki Small Vessel Disease Study (n = 152) were assessed according to an extensive clinical,...
: Subjective cognitive complaints are common in patients with cerebral small vessel disease (cSVD), yet their relationship informant evaluations, objective functions and severity of brain changes poorly understood. We studied the associations subjective reports findings from comprehensive neuropsychological assessment MRI. In Helsinki SVD Study, 152 older adults varying degrees white matter hyperintensities (WMH) but without stroke or dementia were classified as having normal cognition mild...
Background The usefulness of neurofilament light (NfL) as a biomarker for small vessel disease has not been established. We examined the relationship between NfL, neuroimaging changes, and clinical findings in subjects with varying degrees white matter hyperintensity (WMH). Methods A subgroup participants (n = 35) Helsinki Small Vessel Disease Study underwent an analysis NfL cerebrospinal fluid (CSF) well brain magnetic resonance imaging (MRI) neuropsychological motor performance...
Neuropsychiatric symptoms are related to disease progression and cognitive decline over time in cerebral small vessel (SVD) but their significance is poorly understood covert SVD. We investigated neuropsychiatric relationships between functional abilities subjects with varying degrees of white matter hyperintensities (WMH), without clinical diagnosis stroke, dementia or significant disability.The Helsinki Small Vessel Disease Study consisted 152 subjects, who underwent brain magnetic...
Executive functions and processing speed have been regarded as core cognitive domains affected in cerebral small vessel disease (SVD). functions, an umbrella concept, consist of a variety different subcomponents, yet research these abilities are often evaluated with single tests or summary scores. Currently, it is unknown whether all executive equally by SVD brain changes some more sensitive detecting deficits than others. We investigated the associations white matter hyperintensity (WMH)...
Abstract Background and purpose Executive dysfunction slowed processing speed are central cognitive impairments in cerebral small vessel disease (cSVD). It is unclear whether the subcomponents of executive functions become equally affected computerized tests more sensitive detecting early changes over traditional tests. The associations specific abilities (cognitive flexibility, inhibitory control, working memory) with white matter hyperintensities (WMHs) Instrumental Activities Daily Living...
ABSTRACT Steroid receptors are involved in a wide array of crosstalk mechanisms that regulate diverse biological processes, with significant implications diseases, particularly cancers. In prostate cancer, indirect between androgen receptor (AR) and glucocorticoid (GR) is well-documented, where GR replaces antiandrogen-inactivated AR becoming the disease driver. However, existence impact direct chromatin cancer have remained elusive. Our genome-wide investigations reveal activation...
Abstract Background and purpose Neuropsychiatric symptoms are related to disease progression cognitive decline over time in cerebral small vessel (SVD) but their significance is poorly understood covert SVD. We investigated neuropsychiatric relationships between functional abilities subjects with varying degrees of white matter hyperintensities (WMH), without clinical diagnosis stroke, dementia or significant disability. Methods The Helsinki Small Vessel Disease Study consisted 152 subjects,...
ABSTRACT Background and purpose Cerebral small vessel disease (SVD) is characterized by a wide range of focal global brain changes. We used automated MRI segmentation to quantify multiple types SVD changes examined their individual combined predictive value on cognitive functional abilities. Methods scans 560 subjects the Leukoaraiosis Disability Study (LADIS) were analyzed using atlas- convolutional neural network-based methods yielding volumetric measures white matter hyperintensities...
ABSTRACT Objective Cognitive and motor impairments are the key clinical manifestations of cerebral small vessel disease (SVD), but their interrelations combined effects on functional outcome have not been elucidated. We investigated associations between cognitive functions interactions mediating instrumental activities daily living (IADL) quality life in older individuals with various degrees white matter hyperintensities (WMH). Methods Participants Helsinki Small Vessel Disease Study...