A5059118981- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Visual perception and processing mechanisms
- Neurological Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Medical Image Segmentation Techniques
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Neuroscience and Music Perception
- Cardiac Arrest and Resuscitation
- Neural and Behavioral Psychology Studies
- Motor Control and Adaptation
- Advanced Vision and Imaging
- Brain Tumor Detection and Classification
- Retinal Imaging and Analysis
- Stroke Rehabilitation and Recovery
Helsinki University Hospital
2011-2025
University of Helsinki
2009-2025
Imaging Center
2009-2024
Finnish Brain Research and Rehabilitation Center Neuron
2006
We applied fMRI and diffusion-weighted MRI to study the segregation of cognitive motor functions in human cerebro-cerebellar system. Our results show that a load increase nonverbal auditory working memory task is associated with enhanced brain activity parietal, dorsal premotor, lateral prefrontal cortices lobules VII-VIII posterior cerebellum, whereas sensory-motor control activated motor/somatosensory, medial prefrontal, cingulate V/VI anterior cerebellum. The load-dependent crus I/II had...
Background and Purpose- Cerebral small vessel disease is characterized by a wide range of focal global brain changes. We used magnetic resonance imaging segmentation tool to quantify multiple types disease-related changes examined their individual combined predictive value on cognitive functional abilities. Methods- Magnetic scans 560 older individuals from LADIS (Leukoaraiosis Disability Study) were analyzed using automated atlas- convolutional neural network-based methods yielding...
A sudden change in the direction of motion is a particularly salient and relevant feature visual information. Extensive research has identified cortical areas responsive to characterized their sensitivity different features motion, such as directional specificity. However, relatively little known about responses changes direction. Electrophysiological data from animals functional imaging humans suggest number brain presumably working network. Temporal patterns activity allow same network...
Musical competence may confer cognitive advantages that extend beyond processing of familiar musical sounds. Behavioural evidence indicates a general enhancement both working memory and attention in musicians. It is possible musicians, due to their training, are better able maintain focus on task-relevant stimuli, skill which crucial memory. We measured the blood oxygenation-level dependent (BOLD) activation signal musicians non-musicians during sounds determine relation among performance,...
We combined information from functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to assess which cortical areas in temporal order show macroscopic activation after right median nerve stimulation. Five healthy subjects were studied with the two modalities, both revealed significant contra- ipsilateral primary somatosensory cortex (SI), opercular areas, walls of contralateral postcentral sulcus (PoCS), supplementary motor area (SMA). In fMRI, separate foci discerned,...
Purpose: To prospectively evaluate magnetoencephalography (MEG) and functional magnetic resonance (MR) imaging, as compared with intraoperative cortical mapping, for identification of the central sulcus. Materials Methods: Fifteen patients (six men, nine women; age range, 25–58 years) a lesion near primary sensorimotor cortex (13 gliomas, one cavernous hemangioma, meningioma) were examined after institutional review board approval written informed consent from each patient obtained. At MEG,...
Musicians and nonmusicians listened to major, minor, dissonant musical chords while their BOLD brain responses were registered with functional magnetic resonance imaging. In both groups of listeners, minor chords, compared major elicited enhanced in several areas, including the amygdala, retrosplenial cortex, stem, cerebellum, during passive listening but not memorization chords. The results indicate that (1) neural processing emotion-related areas is activated even by single (2) emotion...
THE functional significance of the second somatosensory cortex (SII) is poorly understood. However, lesion and cortical stimulation studies indicate that SII may be involved in sensory aspects tactile learning movement control. In present study, we explored a possible role sensorimotor integration humans using multichannel magnetometer. Somatosensory evoked fields (SEFs) from to electrical left right median nerves were recorded six healthy volunteers during rest different test conditions....
To present applications of magnetoencephalography (MEG) in studies neurosurgical patients.MEG maps magnetic fields generated by electric currents the brain, and allows localization brain areas producing evoked sensory responses spontaneous electromagnetic activity. The identified sources can be integrated with other imaging modalities, e.g., resonance scans individual patients tumors or intractable epilepsy, types data.MEG measurements using modern whole-scalp instruments assist tailoring...
Abstract We demonstrate that spatially accurate and selective stimulation is crucial when cortical functions are studied by the creation of temporary lesions with transcranial magnetic (TMS). Previously, interpretation TMS results has been hampered inaccurate knowledge site strength induced electric current in brain. With a Navigated Brain Stimulation (NBS) system, which provides real‐time resonance image (MRI)‐guided targeting TMS‐induced field, we found restricted S1 thenar area sufficient...
Goal-directed behavior lowers activity in brain areas that include the medial frontal cortex, and lateral parietal limbic paralimbic regions, commonly referred to as "default network." These decreases are believed reflect interruption of processes ongoing when mind is a restful state. Previously, nature these was probed by varying cognitive task parameters, but presence emotional processes, while often assumed, little investigated. With fMRI, we studied effect systematic variations both load...
We report evidence for activation of ipsilateral primary sensorimotor cortex (SMI) after median nerve stimulation recorded with magnetoencephalography (MEG). measured somatosensory evoked magnetic fields (SEFs) to a 122-channel helmet-shaped magnetometer in 10 healthy subjects. In five, the field patterns suggested long-latency SMI. Source locations found by current dipole fitting corresponded SMI hand area, as determined contralateral stimulation. Further origin responses was provided...
Background: Cerebral venous thrombosis (CVT) is a rare cause of stroke with variable clinical presentation and challenging diagnosis. Computed tomography venography (CT‐V) or magnetic resonance (MR‐V) are recommended for detecting CVT, but their diagnostic performance unclear. This systematic review examines the accuracy CT‐V MR‐V in diagnosing CVT. Methods: We performed literature search up to 02 July 2023 retrieve original articles studying patients suspected Studies reference standard...
Cerebral small vessel disease is characterized by progressive white matter hyperintensities (WMH) and cognitive decline. However, variability exists in how individuals maintain capabilities despite significant neuropathology. The relationships between individual reserve, psychological resilience functioning were examined subjects with varying degrees of WMH.In the Helsinki Small Vessel Disease Study, 152 (aged 65-75 years) underwent a comprehensive neuropsychological assessment, evaluation...
Post-traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI). Patients at risk to develop acute PTH (aPTH) and further persistent (pPTH) need be recognized.This one-year follow-up of 127 patients with mTBI, aged 18 68, referred outpatient clinic in the Helsinki University Hospital. Symptoms were assessed emergency department (ED), structured interview visit Rivermead post-concussion questionnaire one, three, 12 months after injury. Psychiatric disorders...
Cognitive and motor impairments are the key clinical manifestations of cerebral small vessel disease (SVD), but their combined effects on functional outcome have not been elucidated. This study investigated interactions mediating cognitive functions instrumental activities daily living (IADL) quality life in older individuals with various degrees white matter hyperintensities (WMH).Participants Helsinki Small Vessel Disease Study (n = 152) were assessed according to an extensive clinical,...
Presents a contextual clustering procedure for statistical parametric maps (SPM) calculated from time varying three-dimensional images. The algorithm can be used the detection of neural activations functional magnetic resonance images (fMRI). An important characteristic SPM is that intensity distribution background (nonactive area) known whereas distributions activation areas are not. developed divides an into and so probability detecting false by chance controlled, i.e., hypothesis testing...
: Subjective cognitive complaints are common in patients with cerebral small vessel disease (cSVD), yet their relationship informant evaluations, objective functions and severity of brain changes poorly understood. We studied the associations subjective reports findings from comprehensive neuropsychological assessment MRI. In Helsinki SVD Study, 152 older adults varying degrees white matter hyperintensities (WMH) but without stroke or dementia were classified as having normal cognition mild...
Background The usefulness of neurofilament light (NfL) as a biomarker for small vessel disease has not been established. We examined the relationship between NfL, neuroimaging changes, and clinical findings in subjects with varying degrees white matter hyperintensity (WMH). Methods A subgroup participants (n = 35) Helsinki Small Vessel Disease Study underwent an analysis NfL cerebrospinal fluid (CSF) well brain magnetic resonance imaging (MRI) neuropsychological motor performance...