A5001800943- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Ginkgo biloba and Cashew Applications
- Cardiovascular Health and Disease Prevention
- Artificial Intelligence in Healthcare
- Cholinesterase and Neurodegenerative Diseases
Amsterdam Neuroscience
2015-2019
Amsterdam University Medical Centers
2018-2019
Vrije Universiteit Amsterdam
2018-2019
Neurology, Inc
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014-2017
A 'frontal variant of Alzheimer's disease' has been described in patients with predominant behavioural or dysexecutive deficits caused by disease pathology. The description this rare phenotype limited to case reports and small series, many clinical, neuroimaging neuropathological characteristics are not well understood. In retrospective study, we included 55 a behavioural-predominant presentation (behavioural disease) diagnosis high-likelihood (n = 17) and/or biomarker evidence pathology...
Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits mild disease dementia. LipiDiDiet investigated effects on cognition and related measures prodromal Here, we report 24-month results trial.LipiDiDiet was a randomised, controlled, double-blind, parallel-group, multicentre trial (11 sites Finland, Germany, Netherlands, Sweden), with optional 12-month double-blind extensions. The enrolled individuals...
Alzheimer's disease (AD) is a heterogeneous disorder with complex underlying neuropathology that still not completely understood. For better understanding of this heterogeneity, we aimed to identify cognitive subtypes using latent class analysis (LCA) in large sample patients AD dementia. In addition, explored the relationship between identified subtypes, and their demographical neurobiological characteristics.We performed LCA based on neuropsychological test results 938 consecutive probable...
Abstract Introduction Patients with Alzheimer's disease (AD) show heterogeneity in profile of cognitive impairment. We aimed to identify subtypes four large AD cohorts using a data‐driven clustering approach. Methods included probable dementia patients from the Amsterdam Dementia Cohort ( n = 496), Disease Neuroimaging Initiative 376), German Competence Network 521), and University California, San Francisco 589). Neuropsychological data were clustered nonnegative matrix factorization....
When differential diagnosis of dementia includes both Alzheimer's disease (AD) and the behavioural variant frontotemporal (bvFTD), distribution cerebral glucose metabolism as measured using [18F]‑2‑fluoro‑2‑deoxy‑d‑glucose positron emission tomography ([18F]FDG-PET) may be helpful. One important clue for differentiation is presence hypometabolism in posterior cingulate cortex (PCC), usually associated with AD. PCC however, could also present bvFTD. Therefore, specificity was examined. Based...
Alzheimer's disease (AD) is a heterogeneous disorder.To investigate whether cognitive AD subtypes are associated with different rates of progression.We included 1,066 probable patients from the Amsterdam Dementia Cohort (n = 290), Disease Neuroimaging Initiative 268), Competence Network 226), and University California, San Francisco 282) available follow-up data. Patients were previously clustered into two based on their neuropsychological test results: one most prominent memory impairment...
Intrinsic functional connectivity (FC) measured by fMRI in the default mode network (DMN) has a potential value as biomarker for disease progression and treatment response (Castellanos et al., 2013; Pievani 2014). However, little is known about inter MRI site consistency of test-retest reproducibility DMN measurements.. Five healthy local volunteers (55-90 ys) were enrolled 13 3T sites (Siemens, GE, Philips) across Europe scanned two sessions at least week apart. A harmonized acquisition...
Abstract Introduction Alzheimer's disease (AD) is associated with synapse loss. Souvenaid, containing the specific nutrient combination Fortasyn Connect, was designed to improve formation and function. The NL‐ENIGMA study explored effect of Souvenaid on function in early AD by assessing cerebral glucose metabolism (CMRglc) 18 F‐fluorodeoxyglucose ([ F]FDG) positron emission tomography (PET). Methods We conducted an exploratory double‐blind randomized controlled single‐center trial. Fifty...
Abstract Background To explore the utility of International Working Group (IWG)-1 criteria in recruitment for Alzheimer’s disease (AD) clinical trials, we applied more recently proposed research diagnostic to individuals enrolled a randomized controlled prevention trial (RCT) and assessed their progression. Methods The multinational LipiDiDiet RCT targeted 311 with IWG-1 defined prodromal AD. Based on centrally analyzed baseline biomarkers, participants were classified according IWG-2...
Abstract Introduction Alzheimer's disease is associated with early synaptic loss. Specific nutrients are known to be rate limiting for synapse formation. Studies have shown that administering specific may improve memory function, possibly by increasing This Dutch study explores the Effect of a Nutritional Intervention on cerebral Glucose Metabolism in (NL‐ENIGMA, Trial Register NTR4718, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4718 ). The NL‐ENIGMA designed test whether...
Alzheimer Disease (AD) is associated with synapse loss. The medical food Souvenaid ®1 contains Fortasyn Connect, a combination of nutrients designed to enhance formation and function in AD. Two earlier studies demonstrated memory improvement mild AD dementia patients after intervention for 12 24 weeks.The 24-week study also showed effects on brain network organisation measured electroencephalography (EEG), which strengthens the hypothesis that affects synaptic function. To provide further...
Hypometabolism of the posterior cingulate cortex (PCC) is associated with Alzheimer's disease (AD). PCC vulnerability, however, could also be present in other neurodegenerative diseases, such as behavioural variant frontotemporal dementia (bvFTD), and normal aging. The aims this study were to assess 1) proportion AD, bvFTD cognitive subjects (CN) hypometabolism, 2) relationship between metabolism demographical, neuropsychological, neurobiological characteristics CN. We included 33 probable...
Increasing evidence suggests substantial heterogeneity in cognitive phenotypes Alzheimer's disease (AD). We aimed to identify subtypes AD dementia by performing latent class analysis (LCA) based on neuropsychological data. For LCA we used data of an extensive test battery 938 patients with probable dementia. In general, were 69±9 (mean ± standard deviation) years old and MMSE was 21±3. performed multinomial logistic regression cluster membership as dependent variable dichotomized...
A “frontal variant of Alzheimer's disease” has been described in patients with predominant behavioral or dysexecutive deficits caused by disease (AD) pathology. The description these rare AD phenotypes limited to case reports and small series, many characteristics are not well understood. We included 55 “behavioral-variant” (bvAD) a neuropathological diagnosis high-likelihood (n=17) and/or biomarker evidence pathology (n=44). In addition, we 29 autopsy/biomarker-defined...
Alzheimer’s disease (AD) dementia is a heterogeneous disorder with variability in cognitive presentation. We aimed to identify AD subtypes using data-driven dual clustering approach. repeated analyses four large independent cohorts assess robustness of the identified subtypes. included probable patients Mini-Mental State Examination score (MMSE) >16/30 from Amsterdam Dementia Cohort (ADC, n=496), Disease Neuroimaging Initiative (ADNI, n=376), German Competence Network (DCN, n=521), and...
Alzheimer Disease (AD) is associated with synapse loss. The medical food Souvenaid ®1 contains Fortasyn Connect, a combination of nutrients designed to enhance formation and function in AD. Two earlier studies demonstrated memory improvement mild AD dementia patients after intervention for 12 24 weeks.The 24-week study also showed effects on brain network organisation measured electroencephalography (EEG), which strengthens the hypothesis that affects synaptic function. To provide further...
Intrinsic functional connectivity (FC) measured by fMRI in the default mode network (DMN) has a potential value as biomarker for disease progression and treatment response (Castellanos et al., 2013; Pievani 2014). However, little is known about inter MRI site consistency of test-retest reproducibility DMN measurements. Five healthy local volunteers (55-90 ys) were enrolled 13 3T sites (Siemens, GE, Philips) across Europe scanned two sessions at least week apart. A harmonized acquisition...
Hypometabolism of the posterior cingulate cortex (PCC) is associated with Alzheimer's disease (AD). PCC vulnerability, however, could also be present in other neurodegenerative diseases, such as behavioural variant frontotemporal dementia (bvFTD), and normal aging. The aims this study were to assess 1) proportion AD, bvFTD cognitive subjects (CN) hypometabolism, 2) relationship between metabolism demographical, neuropsychological, neurobiological characteristics CN. We included 33 probable...
There is considerable heterogeneity in clinical manifestation and rate of decline among patients with Alzheimer's disease (AD). We previously identified two distinct cognitive subtypes four large AD cohorts: the first characterized by prominent memory impairment, second more impairment non-memory domains. Non-memory was associated younger age, APOE e4 negative genotype, atrophy posterior cortex relative spared hippocampi. Taking these as a starting point, we now evaluated whether phenotype...
Alzheimer's disease (AD) is associated with synaptic loss. Souvenaid, containing the specific nutrient combination Fortasyn Connect, was designed to improve synapse formation and function. The NL-ENIGMA study explored effect of Souvenaid on function in early AD by assessing cerebral glucose metabolism (CMRglc) 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET). We conducted an exploratory double-blind randomised controlled single-center trial. Fifty patients mild cognitive...