A5039945921- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
- Parkinson's Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Pituitary Gland Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Cancer-related cognitive impairment studies
- Multiple Sclerosis Research Studies
- NMR spectroscopy and applications
- Childhood Cancer Survivors' Quality of Life
- Lanthanide and Transition Metal Complexes
- Cerebral Palsy and Movement Disorders
- RNA regulation and disease
- Advanced X-ray and CT Imaging
- Tensor decomposition and applications
- Peripheral Nerve Disorders
Skåne University Hospital
2016-2025
Lund University
2009-2023
Centre for Biomedical Engineering and Physics
2018
Kyorin University
2016
École Polytechnique Fédérale de Lausanne
2010
<h3>Objective:</h3> To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD). <h3>Methods:</h3> From prospective, longitudinal BioFINDER study, we included 122 healthy elderly 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). β-Amyloid (Aβ) deposition in 9 brain regions was examined [<sup>18</sup>F]-flutemetamol PET. analyzed INNOTEST EUROIMMUN ELISAs. The results were replicated 146...
The anisotropy of water diffusion in brain tissue is affected by both disease and development. This change can be detected using MRI often quantified the fractional (FA) derived from tensor imaging (DTI). Although FA sensitive to anisotropic cell structures, such as axons, it also their orientation dispersion. a major limitation use biomarker for "tissue integrity", especially regions complex microarchitecture. In this work, we seek circumvent disentangling effects microscopic (μFA) order...
We present the first in vivo application of filter-exchange imaging protocol for diffusion MRI. The allows noninvasive mapping rate water exchange between microenvironments with different self-diffusivities, such as intracellular and extracellular spaces tissue. Since diffusional across cell membrane is a fundamental process human physiology pathophysiology, clinically feasible would offer new means to diagnose disease monitor treatment response conditions cancer edema. use was demonstrated...
Many axons follow wave-like undulating courses. This is a general feature of extracranial nerve segments, but also found in some intracranial nervous tissue. The importance axonal undulation has previously been considered, for example, the context biomechanics, where it shown that posture affects properties. However, diffusion MR measurements not investigated. Using an analytical model and Monte Carlo simulations water diffusion, this study compared straight terms propagators,...
The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms the variance apparent diffusivities within a voxel. However, link between diffusional and is not well-established. To investigate this we test hypothesis that variance, caused microscopic anisotropy isotropic heterogeneity, associated with variable cell eccentricity density brain tumors. We performed dMRI using novel encoding scheme for decomposition (DIVIDE) 7 meningiomas 8 gliomas prior to surgery....
The purpose of this study was to develop multimodality SPECT/ MRI contrast agents for sentinel lymph node (SLN) mapping in vivo.Methods: Nanoparticles with a solid iron oxide core and polyethylene glycol coating were labeled 99m Tc.The labeling efficiency determined instant thin-layer chromatography magnetic separation.The stability the radiolabeled superparamagnetic nanoparticles (SPIONs) verified both sterile water human serum at room temperature 6 24 h after labeling.Five Wistar rats...
Abstract Water exchange through the cell membranes is an important feature of cells and tissues. The rate determined by factors such as membrane lipid composition organization, well type activity aquaporins. A method for noninvasively estimating water would be useful characterizing pathological conditions, e.g., tumors, multiple sclerosis, ischemic stroke, expected to associated with a change barrier properties. This study describes filter imaging determining between sites having different...
Purpose Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on cell membrane permeability. The aim was optimize and analyze ability FEXI infer differences in apparent (AXR) brain between two populations. Methods A protocol optimized for minimal measurement variance AXR. AXR investigated by test‐retest acquisitions six regions 18 healthy volunteers. Preoperative data postoperative microphotos were obtained meningiomas five astrocytomas....
Microstructure imaging techniques based on tensor-valued diffusion encoding have gained popularity within the MRI research community. Unlike conventional encoding-applied along a single direction in each shot-tensor-valued employs multiple directions preparation of signal. The benefit is that such may probe tissue features are not accessible by encoding. For example, diffusional variance decomposition (DIVIDE) takes advantage to microscopic anisotropy independent orientation coherence....
<h3>Objective:</h3> We aimed to test whether in vivo levels of magnetic resonance spectroscopy (MRS) metabolites myo-inositol (mI), N-acetylaspartate (NAA), and choline are abnormal already during preclinical Alzheimer disease (AD), relating these changes amyloid or tau pathology, functional connectivity. <h3>Methods:</h3> In this cross-sectional multicenter study (a subset the prospective Swedish BioFINDER study), we included 4 groups, representing different stages predementia AD: (1)...
Abstract Purpose: To provide estimates of the diffusional kurtosis in healthy brain anatomically defined areas and list these along previously reported values pathologies. Materials Methods: Thirty‐six volunteers (mean age = 33.1 years; range, 19–64 years) underwent imaging. Mean (MK), radial (RK), mean diffusivity (MD), (RD), fractional anisotropy (FA) were determined 26 anatomical structures. Parameter assessed regarding dependence. Results: MK varied from 1.38 splenium corpus callosum to...
Abstract Purpose To evaluate artifact sizes at 3 T compared to 1.5 T, and the influence of scanning parameters with respect size on a 3‐T magnetic resonance imaging (MRI) system. Materials Methods Two aneurysm clips five shunt valves were imaged in water phantom T. At bandwidth (spin echo (SE) images) time (gradient (GRE) (area extension two orthogonal directions) was investigated. Results Artifact increased substantially (typically 5–10 mm) for implants entirely made metallic materials,...
MRI diffusion tensor imaging (DTI) studies of white matter integrity in behavioral variant frontotemporal dementia have consistently shown involvement frontal and temporal matter, corresponding to regional loss cortical volume. Volumetric has a suboptimal sensitivity as diagnostic tool thus we wanted explore if DTI is better method discriminate patients controls than volumetric imaging. We examined the anterior cingulum bundle 14 with 22 healthy using deterministic manual tractography,...
Abstract Background The clinical presentation in progressive supranuclear palsy (PSP), an atypical parkinsonian disorder, includes varying degrees of frontal dysexecutive symptoms. Using diffusion tensor imaging (DTI) and tractography (DTT), we investigated whether changes atrophy the inferior fronto-occipital fasciculus (IFO) occurs PSP if these correlate with disease stage phenotype. corticospinal tract (CST), which is often involved PSP, was for comparison. Methods DTI whole brain...
Aim The aim of this study was to evaluate the extent white matter lesions, atrophy hippocampus and corpus callosum, their correlation with cognitive dysfunction (CD), in patients diagnosed systemic lupus erythematosus (SLE). Methods Seventy SLE 25 healthy individuals (HIs) were included study. To different neuropsychiatric (NPSLE) definition schemes, grouped both according American College Rheumatology (ACR) definition, as well more stringent ACR-Systemic Lupus International Collaborating...
The aim of this study is to identify disease-specific changes the thalamus, basal ganglia, pons, and midbrain in patients with progressive supranuclear palsy (PSP), Parkinson's disease (PD), multiple system atrophy predominant parkinsonism (MSA-P) using diffusion tensor imaging volumetric analysis.MRI data were acquired a derivation 30 controls 8 PSP validation cohort comprised (n = 21) 27), PD 10), MSA-P 11). Analysis was performed regions interest (ROI), tract-based spatial statistic...
Diffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis. The aim was investigate if parameters the perilesional normal-appearing white matter (NAWM) differed from contralesional matter, and differences between glioma malignancy grades II III subtypes (astrocytomas oligodendrogliomas).Forty-eight patients with were prospectively recruited this institutional...
Diffusion tensor imaging (DTI) has been used to study microstructural white matter alterations in a variety of conditions including normal aging and Alzheimer's disease (AD). White hyperintensities (WMH) are common cognitively healthy elderly as well AD exhibit elevated mean diffusivity (MD) reduced fractional anisotropy (FA). However, the effect WMH on statistical analysis DTI estimates not thoroughly studied. In present we address this two ways. First, investigate MD FA dorsal ventral...