A5002886384- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Systemic Lupus Erythematosus Research
- Cerebrovascular and Carotid Artery Diseases
- Radiomics and Machine Learning in Medical Imaging
- Electron Spin Resonance Studies
- Atomic and Subatomic Physics Research
- Acute Ischemic Stroke Management
- Fetal and Pediatric Neurological Disorders
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Alzheimer's disease research and treatments
- Electroconvulsive Therapy Studies
- Metabolomics and Mass Spectrometry Studies
- Numerical methods in inverse problems
- Neurological and metabolic disorders
- Olfactory and Sensory Function Studies
Johns Hopkins University
2017-2025
Johns Hopkins Medicine
2017-2025
Kennedy Krieger Institute
2021-2025
Lund University
2016-2025
Skåne University Hospital
2014-2022
Linköping University
2016
Aalborg University Hospital
2007
Major depression has traditionally been regarded as a neurochemical disease, but findings of decreased hippocampal volume in patients with have turned the pathophysiological focus toward impairments structural plasticity. The mechanisms action most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, recent animal research provided evidence for cell proliferative effect hippocampus. aim this prospective study was to determine if changes after ECT...
Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of use to human studies. Chemical exchange saturation transfer (CEST) at single frequency offset optimized detection hydroxyl protons (glucoCEST) was used image dynamic signal changes brain 7T during and after infusion D-glucose. Dynamic glucose-enhanced (DGE) data from four normal volunteers three glioma patients showed...
The purpose of this study was to develop multimodality SPECT/ MRI contrast agents for sentinel lymph node (SLN) mapping in vivo.Methods: Nanoparticles with a solid iron oxide core and polyethylene glycol coating were labeled 99m Tc.The labeling efficiency determined instant thin-layer chromatography magnetic separation.The stability the radiolabeled superparamagnetic nanoparticles (SPIONs) verified both sterile water human serum at room temperature 6 24 h after labeling.Five Wistar rats...
Purpose Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using for dynamic perfusion imaging explored to detect malignant brain tumors based on blood barrier breakdown. Methods Mice were inoculated orthotopically with human U87-EGFRvIII glioma cells. Time-resolved glucose signal changes detected chemical exchange saturation transfer (glucoCEST) MRI. Dynamic enhanced (DGE) MRI used measure tissue response an intravenous bolus d-glucose....
Altered cerebral glucose uptake is one of the hallmarks Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose and clearance in both brain parenchyma cerebrospinal fluid (CSF). We observed substantially higher young (6 months) transgenic AD mice compared age-matched wild-type (WT) mice. Notably lower uptakes were CSF old (16 Both had an obviously slower than WT This resembles recent reports...
The aim of this study was to improve the accuracy and precision perfusion fraction blood velocity dispersion estimates in intravoxel incoherent motion (IVIM) imaging, using joint analysis flow‐compensated non‐flow‐compensated motion‐encoded MRI data. A double diffusion encoding sequence capable switching between modes implemented. In vivo brain data were collected eight healthy volunteers processed analysis. Simulations used compare performance proposed method with conventional IVIM With...
Purpose As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At same time, large, multisite clinical studies require clearly defined protocols, especially across vendors. Here, we propose a definition standard open Pulseq format for shareable, simple, and exact protocols. Methods We present benefits such in three ways: (1) an database on GitHub, where fully defined, human‐readable protocols can be shared; (2) open‐source...
Purpose Dynamic glucose enhanced (DGE) MRI has shown potential for imaging delivery and blood–brain barrier permeability at fields of 7T higher. Here, we evaluated issues involved with translating d ‐glucose weighted chemical exchange saturation transfer (glucoCEST) experiments to the clinical field strength 3T. Methods Exchange rates different hydroxyl proton pools field‐dependent T 2 relaxivity water in solution were used simulate spectra (Z‐spectra) DGE signal differences as a function...
To investigate the effects of compartmental anisotropy on filtered exchange imaging (FEXI) in white matter (WM).
To compare absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT.CBF was measured in 20 healthy volunteers using DSC-MRI at 3T SPECT. accomplished gradient-echo EPI CBF calculated a time-shift-insensitive deconvolution algorithm regional arterial input functions (AIFs). improve the reproducibility of AIF registration time integral rescaled use venous output function. In SPECT experiment, gas inhaled over 8 minutes...
Monitoring time dependence with diffusion MRI yields observables sensitive to compartment sizes (restricted diffusion) and membrane permeability (water exchange). However, restricted exchange have opposite effects on the diffusion-weighted signal, which can lead errors in parameter estimates. In this work, we propose a signal representation that incorporates of both up second order b-value is compatible gradient waveforms arbitrary shape. The features mappings from waveform two scalars...
Abstract The study aimed to investigate the feasibility of dynamic glucose‐enhanced (DGE) MRI technology in clinical application glioma. Twenty patients with glioma were examined using a preoperative DGE‐MRI protocol before intervention. A brief hyperglycemic state was achieved by injecting 50 mL 50% w/w D‐glucose intravenously during DGE imaging. total acquisition time for 15 min. Area‐under‐the‐curve (AUC) images calculated images. AUC 2–7min values core, margin area, edema and...