A5046084747- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Autoimmune Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Tryptophan and brain disorders
- Advanced Glycation End Products research
- Parkinson's Disease Mechanisms and Treatments
- Gut microbiota and health
- Myasthenia Gravis and Thymoma
- Neurogenesis and neuroplasticity mechanisms
- Sphingolipid Metabolism and Signaling
- Cholesterol and Lipid Metabolism
- Inflammasome and immune disorders
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
- S100 Proteins and Annexins
- Hereditary Neurological Disorders
- Infectious Diseases and Tuberculosis
- Systemic Lupus Erythematosus Research
Jilin University
2015-2024
First Hospital of Jilin University
2015-2024
Mayo Clinic in Arizona
2020
WinnMed
2020
Mayo Clinic
2020
First Bethune Hospital of Jilin University
2019
University of Maryland, Baltimore
2017
Creative Commons
2017
Novem (Netherlands)
2017
Karolinska Institutet
2013-2015
Resolution is the final stage of inflammatory response, when restoration tissue occurs. Failure may lead to chronic inflammation, which known as part pathology in brain individuals with Alzheimer's disease (AD).
The use of supplements with omega-3 (ω3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) is widespread due to proposed beneficial effects on the nervous cardiovascular systems. Many ω3 FAs are believed be caused by down-regulation resolution inflammation. Alzheimer's disease (AD) associated inflammation mediated microglia astrocytes, have been potential treatments for AD. focus present study DHA EPA microglial phagocytosis AD pathogen amyloid-β (Aβ), secreted...
Inflammation plays a role in the pathogenesis of acute-on-chronic liver failure (ACLF), however, whether there is causal relationship between inflammation and ACLF remains unclear. A two-sample Mendelian randomization (MR) approach was used to investigate systemic inflammatory regulators ACLF. The study analyzed 41 cytokines growth factors from 8,293 individuals extracted genome-wide association (GWAS) meta-analysis database involving 253 cases 456,095 controls. Our results showed that lower...
Alzheimer's disease (AD) is one of the most common neurodegenerative and accumulating evidences suggest an active role inflammation in pathogenesis AD. Inflammation resolution process that terminates facilitates restoration inflamed tissue to homeostasis. Resolution has been shown be conducted by a group specialized pro-resolving lipid mediators (SPMs) including lipoxins, resolvins, protectins, maresins (MaRs). Recent studies have demonstrated failure can lead chronic and, hence, contribute...
Abstract Cortical spreading depression ( CSD ), based on its similarities with peri‐infarct depolarization, is an ideal model for investigating transformation from the ischemic penumbra to infarct core. However, underlying mechanisms remain unclear. To our knowledge, this first study use a middle cerebral artery occlusion ischemic‐reperfusion (I/R) injury determine whether AMP ‐activated protein kinase AMPK )‐dependent autophagy contributes neuroprotection of preconditioning in rat cortex....
Resolution of inflammation terminates the inflammatory response in physiological conditions and promotes restoration healing tissue; however, failure resolution results chronic that may lead to disease. Chronic inflammat
Abstract Experimental neural cell therapies, including donor stem/progenitor cells ( NPC s) have been reported to offer beneficial effects on the recovery after an injury and counteract inflammatory degenerative processes in central nervous system CNS ). The interplay between host still a large degree remains unclear, particular human allogeneic conditions. Here, we focused our studies interaction of s microglia utilizing co‐culture model. In co‐cultures, both showed increased survival...
As a result of the COVID-19 pandemic, patients with glioblastoma (GBM) are considered highly vulnerable population. Despite this, extent causative relationship between GBM and infection is uncertain.Genetic instruments for SARS-CoV-2 (38,984 cases 1,644,784 control individuals), hospitalization (8,316 1,549,095 severity (4,792 1,054,664 individuals) were obtained from genome-wide association study (GWAS) European populations. A total 6,183 18,169 controls GWAS enrolled in our study. Their...
Background: Blood-brain barrier (BBB) pathology exists in neuromyelitis optica spectrum disorders (NMOSD). However, the clinical use of BBB permeability, such as predicting disease severity NMOSD, has rarely been studied a large cohort patients. Objectives: The current study explored association between permeability and parameters order to assess if could be biomarker predict characteristics NMOSD. Methods: Among 69 enrolled NMOSD patients, 47 with albumin index over 5 × 10-3 were assigned...
Background Generalized convulsive epilepsy (GCE), an important subtype of epilepsy, is a syndrome neuronal dysfunction characterized by diffuse abnormal discharge neurons within the brain. Compounding evidence suggests correlation between and inflammatory factors, for instance, cyclooxygenase-2, interleukin-1β, interleukin-6. Elevated levels factors have been observed in patients with several animal models. Therefore, inflammation may be closely associated pathogenesis progression GCE....
Abstract Multiple sclerosis is an inflammatory disorder characterized by inflammation, demyelination, and neurodegeneration in the central nervous system. Although current first-line therapies can help manage symptoms slow down disease progression, there no cure for multiple sclerosis. The gut-brain axis refers to complex communications between gut flora immune, nervous, endocrine systems, which bridges functions of brain. Disruptions flora, termed dysbiosis, lead systemic leaky syndrome,...
Rationale: Longitudinally extensive transverse myelitis (LETM) is characterized by contiguous inflammatory lesions of spinal cord extending to ≥3 vertebral segments. The etiology LETM complicated, including various infection, autoimmune disease, and so on. Neuromyelitis optic spectrum disorder (NMOSD) the most common cause LETM. Several case reports have suggested associations between NMOSD pulmonary tuberculosis (PTB). Patient concerns: 1, a 20-year-old woman who had past history PTB,...
Parkinson's disease (PD) is one of the most common nervous system degenerative diseases. However, etiology this remains elusive. Here, a proteasome inhibitor (PSI)-induced undifferentiated SH-SY5Y PD model was established to analyze protein alterations through proteomic study.Cultured cells were divided into control group and treated with 2.5 µM PSI (PSI-treated group). An methyl thiazolyl tetrazolium (MTT) assay applied detect cell viability. Acridine orange/ethidium bromide (AO/EB),...