A5033335614- Peripheral Neuropathies and Disorders
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Hereditary Neurological Disorders
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and Diving-Related Complications
- Acute Ischemic Stroke Management
- Myasthenia Gravis and Thymoma
- Infectious Encephalopathies and Encephalitis
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- Tryptophan and brain disorders
- Macrophage Migration Inhibitory Factor
- Gut microbiota and health
- Dementia and Cognitive Impairment Research
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Risk Factors
- Brain Metastases and Treatment
- Radiation Dose and Imaging
Jilin University
2016-2025
First Hospital of Jilin University
2016-2025
Shenzhen University
2022
Creative Commons
2017
Medical Research Council
2017
National Natural Science Foundation of China
2017
Karolinska Institutet
2016
Center for Neurosciences
2016
Weatherford College
2015
First Bethune Hospital of Jilin University
2013-2014
Abstract Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes. It is predominantly found in astrocytes which are most abundant subtypes glial cells brain spinal cord. As a marker astrocytes, GFAP may exert variety physiological effects neurological diseases. For example, previous published literatures showed that autoimmune astrocytopathy inflammatory disease central...
Abstract Introduction Guillain-Barré syndrome (GBS) is an immune-mediated disorder of the peripheral nervous system. Respiratory failure requiring mechanical ventilation (MV) a serious complication GBS. Identification modifiable risk factors for MV and poor short-term prognosis in mechanically ventilated patients with GBS may contribute to individualized management help improve outcome patients. Methods We retrospectively analyzed clinical data 541 who were diagnosed from 2003 2014....
It is unknown whether high systolic blood pressure had a similar effect on the disease burden of stroke subtypes. The aim our study to compare long-term trends subtypes and sex groups attributable in China from 1990 2019. Data about age-standardized mortality rate disability-adjusted life-year were extracted GBD (Global Burden Disease) calculated using liner regression age-period-cohort method, adjusted for age, period, cohort. estimated annual percentage change was different subtypes, with...
Background Stroke is a major global cause of death and disability, with high body mass index (HBMI) as key modifiable risk factor. Understanding HBMI‐attributable stroke burden crucial for effective prevention. Methods Results Using Global Burden Disease 2021 data, we analyzed disability‐adjusted life years mortality from its subtypes (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage) attributable to HBMI at global, regional, national levels 1990 2021. We conducted...
Objective Clinical characteristics of pediatric Guillain-Barré syndrome (GBS) have been extensively studied whereas scarcely compared with those adult GBS. Herein we the clinical features GBS between and patients. Methods We retrospectively collected data 750 patients (541 adults 209 children), children adults. Results Pain was a more frequent complaint in (17.2% vs 9.6%, p < 0.01), who were also found shorter interval from disease onset to nadir (6.3d 7.3d, 0.01) higher incidence bulbar...
Background The association between RLS and migraine is still debated. aim of this study to investigate the prevalence grade in Chinese patients with evaluate relationship migraine. Methods A multi-center case-control contrast-enhanced transcranial Doppler was conducted 931 consecutive (240 had aura 691 were without group) 282 healthy adults. Clinical trial no. NCT02425696. Results 63.8% 39.9% group (MA+) (MA−), respectively, significantly higher than that (29.4%, p < 0.001; 0.001)....
Intraplaque neovascularisation (IPN) increases the vulnerability of plaques, which makes them more likely to rupture and risk vascular events. However, it is unclear whether IPN can predict future events (stroke recurrence cardiovascular events). Previous studies on have focused patients with severe stenosis but overlooked mild moderate stenosis. This study aimed investigate assessed by contrast-enhanced ultrasonography (CEUS) in degrees associated events.One hundred twenty-one participated...
Objective: Intraplaque neovascularization is a marker of plaque vulnerability and used to predict the risk future vascular events in patients with symptomatic carotid stenosis; however, its association asymptomatic stenosis has not been prospectively evaluated. Therefore, this study aimed explore between intraplaque assessed using contrast-enhanced ultrasound occurrence ischemic diagnosed stenosis. Methods: We recruited from our center. Contrast-enhanced was performed at baseline. The...
Abstract Multiple sclerosis is an inflammatory disorder characterized by inflammation, demyelination, and neurodegeneration in the central nervous system. Although current first-line therapies can help manage symptoms slow down disease progression, there no cure for multiple sclerosis. The gut-brain axis refers to complex communications between gut flora immune, nervous, endocrine systems, which bridges functions of brain. Disruptions flora, termed dysbiosis, lead systemic leaky syndrome,...
Phospholipase D (PLD) is an enzyme that consists of six isoforms (PLD1–PLD6) and has been discovered in different organisms including bacteria, viruses, plants, mammals. PLD involved regulating a wide range nerve cells’ physiological processes, such as cytoskeleton modulation, proliferation/growth, vesicle trafficking, morphogenesis, development. Simultaneously, PLD, which also plays essential role the pathogenesis neurodegenerative neuroimmune diseases. In this review, family members,...
There is evidence that the transplantation of mesenchymal stem cells into rat models cerebral ischemia reduces ischemic damage; however, mechanism remains to be elucidated. The present study aimed assess effect human bone marrow stromal (hBMSCs) on neurologic function and expression vascular endothelial growth factor (VEGF) in a model focal ischemia. left middle artery adult Wistar rats was occluded for 90 min using nylon thread, followed by reperfusion 1 h. hBMSCs labeled with...
Accumulating evidence suggests that alterations in liver function may play an important role the pathogenesis of Alzheimer's disease (AD). However, it remains unclear whether there is any relationship between lower and cognitive impairment among elderly.From 2017 to 2018, we recruited 7,201 older people (over 60 years old) from 51 community health centers Luohu District Shenzhen City. According Mini-Mental State Examination (MMSE) score education level, participants were divided into a group...
Ganglioside as a neurotrophic drug has been hitherto widely used in China, although Guillain-Barré syndrome (GBS) following intravenous ganglioside treatment was reported Europe several decades ago. We identified 7 patients who developed GBS after use of gangliosides (ganglioside+ group) and compared their clinical data with those 77 non-ganglioside-associated (ganglioside− 2013, aiming at gaining the distinct features ganglioside-associated GBS. Although mean age, protein levels...